scholarly journals Electro-Optofluidicis: Achieving Dynamic Control On-Chip

2013 ◽  
Vol 104 (2) ◽  
pp. 503a
Author(s):  
Mohammad Soltani ◽  
James Inman ◽  
Michal Lipson ◽  
Michelle D. Wang
Keyword(s):  
2012 ◽  
Vol 20 (20) ◽  
pp. 22314 ◽  
Author(s):  
Mohammad Soltani ◽  
James T. Inman ◽  
Michal Lipson ◽  
Michelle D. Wang
Keyword(s):  

Nanophotonics ◽  
2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Hongnan Xu ◽  
Chaoyue Liu ◽  
Daoxin Dai ◽  
Yaocheng Shi

Abstract By leveraging mode-division multiplexing (MDM), capacity of on-chip photonic interconnects can be scaled up to an unprecedented level. The demand for dynamic control of mode carriers has led to the development of mode-division multiplexing switches (MDMS), yet the conventional MDMS is incapable of directly accessing an individual lower-order mode that propagates in a multi-mode bus waveguide, which hinders its scalability and flexibility. In this paper, we propose and demonstrate the first direct-access MDMS as a novel platform for scalable on-chip multi-mode networks. At first, the highly efficient mode exchangers are developed for TE0–TE2 and TE1–TE2 mode swap, which are then employed to realize the direct-access mode add-drop multiplexers with high performances. The direct-access MDMS is then achieved based on the proposed mode add-drop multiplexers, which can be used for dynamically adding and dropping any selected mode carrier in a three-channel MDM. Moreover, the novel direct-access scheme is also adopted to simultaneously harness wavelength and mode carriers, leading to a wavelength/mode-hybrid multiplexing system with an enhanced link capacity of twelve channels. To further verify the utility of the MDMS, a multi-mode hubbed-ring network is constructed, where one hub and three nodes are organized within a ring-like multi-mode bus waveguide. The reconfigurable network traffic of 6 × 10 Gbps data streams are obtained by using three eigen modes as signal carriers. The measurement results show low bit-error rates (<10−9) with low power penalties (<3.1 dB).


Author(s):  
Zhanjie Shao ◽  
Carolyn L. Ren ◽  
Gerry E. Schneider

A numerical model has been developed and is used to study the loading and dispensing processes in on-chip cross-linked microchannels. The electrokinetic transport characteristics and the roles of species’ electrophoretic mobilities and diffusion coefficients on the electrokinetic flow are revealed. A study is also performed on an implementation of multi-stage injection. The study of conventional one-step injection and separation is performed and helps construct a distinct understanding of the processes. Species movement and sample plug development with diffusion are examined; results include concentration profiles and contour plots over a range of injection and separation time. Real-time monitoring of different species’ movements is performed for injection guidance. Some limitations of the separation process are presented with potential solutions, such as the removable tail effect and exceptional quick diffusion. Using innovative dynamic control, efforts are made to control the flow and species transport for improved sample plugs, which is key to achieving excellent electrophoretic separation. Through a series of multi-step injection schemes, four typical sample plugs are produced with specific attributes such as reduced dispersion leakage, desirable sample plug size, enhanced shape, etc. Comparisons of conventional and the proposed methods are performed. Typical resulting sample plugs are evaluated using the two developed parameters of resolution and detectability for numerically simulated separation processes. Depending on requirements, one can generate some specific sample plugs through this multi-step dynamic injection method. The resulting understanding will assist in the design of microfluidic devices for separation by providing insight into the process influences and controls and by identifying areas for further research.


2012 ◽  
Vol 20 (20) ◽  
pp. 22327 ◽  
Author(s):  
Mohammad Soltani ◽  
James T. Inman ◽  
Michal Lipson ◽  
Michelle D. Wang
Keyword(s):  

2020 ◽  
Vol 477 (14) ◽  
pp. 2679-2696
Author(s):  
Riddhi Trivedi ◽  
Kalyani Barve

The intestinal microbial flora has risen to be one of the important etiological factors in the development of diseases like colorectal cancer, obesity, diabetes, inflammatory bowel disease, anxiety and Parkinson's. The emergence of the association between bacterial flora and lungs led to the discovery of the gut–lung axis. Dysbiosis of several species of colonic bacteria such as Firmicutes and Bacteroidetes and transfer of these bacteria from gut to lungs via lymphatic and systemic circulation are associated with several respiratory diseases such as lung cancer, asthma, tuberculosis, cystic fibrosis, etc. Current therapies for dysbiosis include use of probiotics, prebiotics and synbiotics to restore the balance between various species of beneficial bacteria. Various approaches like nanotechnology and microencapsulation have been explored to increase the permeability and viability of probiotics in the body. The need of the day is comprehensive study of mechanisms behind dysbiosis, translocation of microbiota from gut to lung through various channels and new technology for evaluating treatment to correct this dysbiosis which in turn can be used to manage various respiratory diseases. Microfluidics and organ on chip model are emerging technologies that can satisfy these needs. This review gives an overview of colonic commensals in lung pathology and novel systems that help in alleviating symptoms of lung diseases. We have also hypothesized new models to help in understanding bacterial pathways involved in the gut–lung axis as well as act as a futuristic approach in finding treatment of respiratory diseases caused by dysbiosis.


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