S4-S5 Linker Regulates RyR2 Channel Gating through Multiple Interactions

Abstract Laser-assisted device alteration (LADA) is an established technique used to identify critical speed paths in integrated circuits. LADA can reveal the physical location of a speed path, but not the timing of the speed path. This paper describes the root cause analysis benefits of 1064nm time resolved LADA (TR-LADA) with a picosecond laser. It shows several examples of how picosecond TR-LADA has complemented the existing fault isolation toolset and has allowed for quicker resolution of design and manufacturing issues. The paper explains how TR-LADA increases the LADA localization resolution by eliminating the well interaction, provides the timing of the event detected by LADA, indicates the propagation direction of the critical signals detected by LADA, allows the analyst to infer the logic values of the critical signals, and separates multiple interactions occurring at the same site for better understanding of the critical signals.

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Faculty Opinions recommendation of Binding dynamics of structural nucleoporins govern nuclear pore complex permeability and may mediate channel gating.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1011430.180167 ◽

2003 ◽

Author(s):

Murray Stewart

Keyword(s):

Nuclear Pore Complex ◽

Channel Gating ◽

Complex Permeability ◽

Nuclear Pore

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Faculty Opinions recommendation of Congenital stationary night blindness type 2 mutations S229P, G369D, L1068P, and W1440X alter channel gating or functional expression of Ca(v)1.4 L-type Ca2+ channels.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1024014.285837 ◽

2005 ◽

Author(s):

Gerald Zamponi

Keyword(s):

Night Blindness ◽

Channel Gating ◽

Functional Expression ◽

Congenital Stationary Night Blindness ◽

Ca2 Channels

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Faculty Opinions recommendation of Multiple interactions of the intrinsically disordered region between the helicase and nuclease domains of the archaeal Hef protein.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718458952.793496527 ◽

2014 ◽

Author(s):

Vladimir Uversky

Keyword(s):

Intrinsically Disordered ◽

Intrinsically Disordered Region ◽

Multiple Interactions

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Multiple interactions in riverine biofilms - surfactant adsorption, bacterial attachment and biodegradation

Water Science & Technology ◽

10.2166/wst.1995.0015 ◽

1995 ◽

Vol 31 (1) ◽

pp. 61-70 ◽

Cited By ~ 6

Author(s):

Graham F. White

Keyword(s):

Organic Pollutants ◽

Bacterial Attachment ◽

Solid Surfaces ◽

Sediment Surface ◽

Liquid Interfaces ◽

Polluted Soils ◽

Biofilm Bacteria ◽

The Impact ◽

Multiple Interactions

Many organic pollutants, especially synthetic surfactants, adsorb onto solid surfaces in natural and engineered aquatic environments. Biofilm bacteria on such surfaces make major contributions to microbial heterotrophic activity and biodegradation of organic pollutants. This paper reviews evidence for multiple interactions between surfactants, biodegradative bacteria, and sediment-liquid interfaces. Biodegradable surfactants e.g. SDS, added to a river-water microcosm were rapidly adsorb to sediment surface and stimulated the indigenous bacteria to attach to the sediment particles. Recalcitrant surfactants and non-surfactant organic nutrients did not stimulate attachment Attachment of bacteria was maximal when biodegradation was fastest, and was reversed when biodegradation was complete. Dodecanol, the primary product of SDS-biodegradation, markedly stimulated attachment. When SDS was added to suspensions containing sediment and either known degraders or known non-degraders, only the degraders became attached, and attachment accelerated surfactant biodegradation to dodecanol. These cyclical cooperative interactions have implications for the design of biodegradability-tests, the impact of surfactant adjuvants on biodegradability of herbicides/pesticides formulated with surfactants, and the role of surfactants used to accelerate bioremediation of hydrocarbon-polluted soils.

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AMPA and Kainate Receptors

The Oxford Handbook of Neuronal Ion Channels ◽

10.1093/oxfordhb/9780190669164.013.8 ◽

2020 ◽

Author(s):

G. Brent Dawe ◽

Patricia M. G. E. Brown ◽

Derek Bowie

Keyword(s):

Ion Channel ◽

Glutamate Receptor ◽

Single Channel ◽

Channel Gating ◽

Regulatory Proteins ◽

Kainate Receptors ◽

Mammalian Brain ◽

Receptor Field ◽

Neuronal Excitation ◽

Ion Channel Proteins

α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and kainate-type glutamate receptors (AMPARs and KARs) are dynamic ion channel proteins that govern neuronal excitation and signal transduction in the mammalian brain. The four AMPAR and five KAR subunits can heteromerize with other subfamily members to create several combinations of tetrameric channels with unique physiological and pharmacological properties. While both receptor classes are noted for their rapid, millisecond-scale channel gating in response to agonist binding, the intricate structural rearrangements underlying their function have only recently been elucidated. This chapter begins with a review of AMPAR and KAR nomenclature, topology, and rules of assembly. Subsequently, receptor gating properties are outlined for both single-channel and synaptic contexts. The structural biology of AMPAR and KAR proteins is also discussed at length, with particular focus on the ligand-binding domain, where allosteric regulation and alternative splicing work together to dictate gating behavior. Toward the end of the chapter there is an overview of several classes of auxiliary subunits, notably transmembrane AMPAR regulatory proteins and Neto proteins, which enhance native AMPAR and KAR expression and channel gating, respectively. Whether bringing an ion channel novice up to speed with glutamate receptor theory and terminology or providing a refresher for more seasoned biophysicists, there is much to appreciate in this summation of work from the glutamate receptor field.

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Multiple interactions between insect lipoproteins and fat body cells: extracellular trapping and endocytic trafficking

The Journal of Lipid Research ◽

10.1016/s0022-2275(20)32176-3 ◽

1998 ◽

Vol 39 (9) ◽

pp. 1877-1888 ◽

Cited By ~ 1

Author(s):

Nico P. Dantuma ◽

Marian A.P. Pijnenburg ◽

Jacques H.B. Diederen ◽

Dick J. Van der Horst

Keyword(s):

Fat Body ◽

Endocytic Trafficking ◽

Multiple Interactions

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Progress in research on the role of fibrinogen in lung cancer

Open Life Sciences ◽

10.1515/biol-2020-0035 ◽

2020 ◽

Vol 15 (1) ◽

pp. 326-330

Author(s):

Xing Liu ◽

Bin Shi

Keyword(s):

Lung Cancer ◽

Coagulation Factor ◽

Coagulation System ◽

Plasma Coagulation ◽

Hepatic Cells ◽

Tumor Growth And Metastasis ◽

Cancer Côlon ◽

The Relationship ◽

Multiple Interactions

AbstractLung cancer is one of the most prevalent malignancies worldwide. Local recurrence and distant metastasis remain the major causes of treatment failure. It has been recognized that the process of tumor growth and metastasis involves multiple interactions between tumor and host. Various biomarkers have been used for predicting tumor recurrence, metastasis, and prognosis in patients with lung cancer. However, these biomarkers are still controversial and require further validation. The relationship between malignancy and coagulation system disorders has been explored for more than a century. Fibrinogen is the most abundant plasma coagulation factor synthesized mainly by hepatic cells. Increased plasma fibrinogen levels were observed in various carcinomas such as gastric cancer, colon cancer, and pancreatic cancer. Recent studies have also investigated the role of fibrinogen in patients with lung cancer. This review aimed to address the role of fibrinogen in lung cancer.

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