scholarly journals Sex-Related Differences in Sarcomeric Protein Expression in Guinea Pig Masticatory Muscles

2018 ◽  
Vol 114 (3) ◽  
pp. 138a
Author(s):  
Peter J. Reiser ◽  
Natalya Belevych ◽  
Kelly Doan ◽  
Jarid R. Jones ◽  
Suarav Kadatane
Keyword(s):  
Guinea Pig ◽  
Protein Expression ◽  
Masticatory Muscles ◽  
Sarcomeric Protein

Studies on the fibre types of the guinea pig masticatory muscles

1974 ◽  
Vol 47 (4) ◽  
pp. 1171-1184 ◽  
Author(s):  
Masuda Koji ◽  
Takahashi Shoichiro ◽  
Kuriyama Hirosi
Keyword(s):  
Guinea Pig ◽  
Masticatory Muscles ◽  
Fibre Types

Molecular basis of species-specific expression of repolarizing K+ currents in the heart

2003 ◽  
Vol 285 (4) ◽  
pp. H1641-H1649 ◽  
Author(s):  
Stephen Zicha ◽  
Isaac Moss ◽  
Bruce Allen ◽  
Andras Varro ◽  
Julius Papp ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Protein Expression ◽  
Guinea Pigs ◽  
Delayed Rectifier ◽  
Important Species ◽  
Α Subunit ◽  
Delayed Rectifier Current ◽  
Mrna Concentration ◽  
Subunit Expression ◽  
Species Specific

There are important species-specific differences in K+ current profiles and arrhythmia susceptibility, but interspecies comparisons of K+ channel subunit expression are lacking. We quantified voltage-gated K+ channel (Kv) subunit mRNA and protein in rabbits, guinea pigs, and humans. Kv1.4, Kv4.2, and Kv4.3 mRNA was present in rabbits but undetectable in guinea pigs. MinK mRNA concentration in guinea pigs was almost threefold greater versus humans and 20-fold versus rabbits. MinK protein expression in guinea pigs was almost twofold that in humans and sixfold that in rabbits. KvLQT1 mRNA concentration was greatest in humans, and protein expression in humans was increased by ∼2- and ∼7-fold compared with values in rabbits and guinea pigs, respectively. The ether-a-go-go-related gene (ERG1) mRNA was more concentrated in humans, but ERG1 protein expression could not be compared across species because of epitope sequence differences. We conclude that important interspecies differences in cardiac K+ channel subunit expression exist and may contribute to the following: 1) lack of a transient outward current in the guinea pig (α-subunit transcription absent in the guinea pig heart); 2) small slow delayed rectifier current and torsades de pointes susceptibility in the rabbit (low-level minK expression); and 3) large slow component of the delayed rectifier current in the guinea pig (strong minK expression).

Sympathetic denervation-induced changes in G protein expression in enteric neurons of the guinea pig colon

Life Sciences ◽  
2002 ◽  
Vol 71 (17) ◽  
pp. 1961-1973 ◽  
Author(s):  
Cristina Giaroni ◽  
Elena Zanetti ◽  
Alessandro Vanti ◽  
Luca Canciani ◽  
Sergio Lecchini ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Protein Expression ◽  
G Protein ◽  
Enteric Neurons ◽  
Sympathetic Denervation ◽  
Induced Changes

Trichinella spiralis infection affects p47phox protein expression in guinea-pig alveolar macrophages

2006 ◽  
Vol 112 (3) ◽  
pp. 158-163 ◽  
Author(s):  
Jolanta M. Dzik ◽  
Zbigniew Zieliński ◽  
Barbara Gołos ◽  
Elżbieta Wałajtys-Rode
Keyword(s):  
Guinea Pig ◽  
Protein Expression ◽  
Alveolar Macrophages ◽  
Trichinella Spiralis

Evidence of Altered Guinea Pig Ventricular Cardiomyocyte Protein Expression and Growth in Response to a 5 min in vitro Exposure to H2O2

2010 ◽  
Vol 9 (4) ◽  
pp. 1985-1994 ◽  
Author(s):  
Vidya Seenarain ◽  
Helena M. Viola ◽  
Gianina Ravenscroft ◽  
Tammy M. Casey ◽  
Richard J. Lipscombe ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Protein Expression ◽  
In Vitro Exposure

scholarly journals Acute Noise Causes Down-Regulation of ECM Protein Expression in Guinea Pig Cochlea

2021 ◽  
Author(s):  
Min Shi ◽  
Lei Shi ◽  
Daxiong Ding ◽  
Yiyong Hu ◽  
Guowei Qi ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Protein Expression ◽  
Focal Adhesion ◽  
Noise Exposure ◽  
Collagen Type ◽  
Hearing Threshold ◽  
Down Regulation ◽  
Marker Proteins ◽  
Proteomics Technology ◽  
Before And After

Abstract Background: Proteomics technology reveals the marker proteins, potential pathogenesis and intervention targets after noise-induced hearing loss.To study the differences in cochlea protein expression before and after noise exposure using proteomics to reveal the pathological mechanism of noise-induced hearing loss (NIHL).Methods: A guinea pig NIHL model was established to test the ABR thresholds before and after noise exposure. The proteomics technology was used to study the mechanism of differential protein expression in the cochlea by noise stimulation.Results: The average hearing threshold of guinea pigs on the first day after noise exposure was 57.00±6.78dB SPL; the average hearing threshold on the seventh day after noise exposure was 45.83±6.07dB SPL,. The proteomics technology identified 3122 different inner ear proteins, of which six proteins related to the hearing were down-regulation: TenascinC, Collagen type XI alpha two chains, Collagen type II alpha one chain, Thrombospondin 2, Collagen type XI alpha one chain and Ribosomal protein L38, and are enriched in protein absorption, focal adhesion, and extracellular matrix receptor pathways.Conclusion: Impulse noise can affect the expression of differential proteins through focal adhesion pathways. This data can provide an experimental basis for the research on the prevention and treatment of NIHL.Trial registration: Not applicable.

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