Three Unusual Cases of Radioactive Iodine-125 Seed Migration to the Heart

In rats with 2-week obstructive jaundice the sensitivity to endotoxin was studied and the effect of a single dose of endotoxin on histological development in the kidney, liver and spleen was also investigated. We were tested the effect on accumulation and distribution within organs, of fibrinogen labelled with radioactive iodine 125. We showed an increased sensitivity to endotoxin in obstructive jaundice. The cause of death in most rats was acute circulatory failure during the course of endotoxic shock, without clinical features of disseminated intravascular coagulation. In the isotope study, after endotoxin administration there was a specific dynamic increase of fibrinogen accumulation in the kidneys of rats with obstructive jaundice. We proposed, that the cause of the kidney changes during the course of obstructive jaundice could be the local activation of intrarenal coagulation.

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Radioactive iodine-125 seed localization as an aid in reoperative neck surgery

The American Journal of Surgery ◽

10.1016/j.amjsurg.2020.12.048 ◽

2021 ◽

Author(s):

Michael D. Bortz ◽

Amna Khokar ◽

David J. Winchester ◽

Tricia A. Moo-Young ◽

David B. Ecanow ◽

...

Keyword(s):

Radioactive Iodine ◽

Neck Surgery ◽

Seed Localization ◽

Iodine 125

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Normal Brain Irradiation during Stereotactic Brain Implants Using Radioactive Iodine-125

Stereotactic and Functional Neurosurgery ◽

10.1159/000100732 ◽

1987 ◽

Vol 50 (1-6) ◽

pp. 310-313

Author(s):

S.K. Jani ◽

P.W. Hitchon ◽

J.C. Van Gilder ◽

B. Chen Wen

Keyword(s):

Radioactive Iodine ◽

Normal Brain ◽

Brain Irradiation ◽

Brain Implants ◽

Iodine 125

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232. The role of radioactive iodine-125 seed localization in breast conserving therapy following neoadjuvant chemotherapy

European Journal of Surgical Oncology ◽

10.1016/j.ejso.2012.06.227 ◽

2012 ◽

Vol 38 (9) ◽

pp. 808

Author(s):

E.J.T. Luiten ◽

P.D. Gobardhan ◽

L.L. de Wall ◽

L. van der Laan ◽

A.J. ten Tije ◽

...

Keyword(s):

Neoadjuvant Chemotherapy ◽

Radioactive Iodine ◽

Breast Conserving Therapy ◽

Seed Localization ◽

Iodine 125

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Puncture and Dose Accuracies of Navigation-Assisted 3D-Printing Templates Combined with Computed Tomography Guided Radioactive Iodine-125 Seed Implantation in the Treatment of Malignant Tumors

10.21203/rs.3.rs-120621/v1 ◽

2020 ◽

Author(s):

Zhe Ji ◽

Yuliang Jiang ◽

Haitao Sun ◽

Fuxin Guo ◽

Jinghong Fan ◽

...

Keyword(s):

Computed Tomography ◽

Radioactive Iodine ◽

Malignant Tumors ◽

Insertion Point ◽

Seed Implantation ◽

Significant Difference ◽

Tip Position ◽

Iodine 125 ◽

Preoperative Plan ◽

Nonparametric Correlation

Abstract Objective: To preliminarily verify the accuracy of navigation-assisted seed implantation by comparing preoperative and actual differences in puncture characteristics and dosimetry in computed tomography-guided, navigation-assisted radioactive iodine-125 seed implantation using 3D-printed templates for the treatment of malignant tumors. Methods: A total of 27 tumor patients who were treated with seed implantation under combination guidance in our hospital between December 2018 to December 2019 were enrolled in this study. Navigation needles (n=1–3) were placed in each patient to obtain preoperative and intraoperative puncture information, including angle, depth, insertion point, and tip position; we also investigated the dosimetry parameters in the preoperative and postoperative plans, including D90, V100, V150, V200, minimum peripheral dose (MPD), conformal index, external index, and homogeneity index of the target area. The t-tests and nonparametric correlation tests were used for analysis (P<0.05 was considered significant). Results: The means errors of the angle, depth, insertion point, and tip position were 0.47 ± 0.521°, 0.35 ± 0.238 cm, 1.7 ± 0.99 mm, and 3.1 ± 1.75 mm, respectively. There were no significant differences between the intraoperative and preoperative angles (P = 0.271), but there was a significant difference in depth (P = 0.002). Errors of the angle, depth, and insertion point were larger for the pelvic/retroperitoneal area than for the head and neck/chest wall (P < 0.05). With the exception of MPD, there was no significant difference in dosimetry indices between the postoperative and preoperative plans (P > 0.05). The MPD in the postoperative plan was higher than that in the preoperative plan (mean: 72.1 Gy and 63.8 Gy, respectively; P < 0.05). Conclusion: Seed implantation under combination guidance showed good accuracy, and the actual intraoperative puncture information and postoperative doses were in good agreement with those in the preoperative plan, thereby demonstrating promising prospects for further development.

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Radioactive Iodine-125 in Tumor Therapy: Advances and Future Directions

Frontiers in Oncology ◽

10.3389/fonc.2021.717180 ◽

2021 ◽

Vol 11 ◽

Author(s):

Shuhua Wei ◽

Chunxiao Li ◽

Mengyuan Li ◽

Yan Xiong ◽

Yuliang Jiang ◽

...

Keyword(s):

Clinical Trials ◽

Radioactive Iodine ◽

External Beam Radiotherapy ◽

Tumor Therapy ◽

Target Lesion ◽

Metal Stents ◽

Treatment Planning Systems ◽

Technological Advances ◽

Iodine 125 ◽

Almost All

Radioactive iodine-125 (I-125) is the most widely used radioactive sealed source for interstitial permanent brachytherapy (BT). BT has the exceptional ability to deliver extremely high doses that external beam radiotherapy (EBRT) could never achieve within treated lesions, with the added benefit that doses drop off rapidly outside the target lesion by minimizing the exposure of uninvolved surrounding normal tissue. Spurred by multiple biological and technological advances, BT application has experienced substantial alteration over the past few decades. The procedure of I-125 radioactive seed implantation evolved from ultrasound guidance to computed tomography guidance. Compellingly, the creative introduction of 3D-printed individual templates, BT treatment planning systems, and artificial intelligence navigator systems remarkably increased the accuracy of I-125 BT and individualized I-125 ablative radiotherapy. Of note, utilizing I-125 to treat carcinoma in hollow cavity organs was enabled by the utility of self-expandable metal stents (SEMSs). Initially, I-125 BT was only used in the treatment of rare tumors. However, an increasing number of clinical trials upheld the efficacy and safety of I-125 BT in almost all tumors. Therefore, this study aims to summarize the recent advances of I-125 BT in cancer therapy, which cover experimental research to clinical investigations, including the development of novel techniques. This review also raises unanswered questions that may prompt future clinical trials and experimental work.

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Novel surgical technique to selectively remove metastatic axillary lymph nodes in breast cancer patients after neoadjuvant chemotherapy: The MARI procedure—Marking of the axilla with radioactive iodine seeds.

Journal of Clinical Oncology ◽

10.1200/jco.2012.30.27_suppl.196 ◽

2012 ◽

Vol 30 (27_suppl) ◽

pp. 196-196

Author(s):

Marie-Jeanne TFD Vrancken Peeters ◽

Marieke Evelien Straver ◽

Mila Donker ◽

Claudette Loo ◽

Gabe S. Sonke ◽

...

Keyword(s):

Lymph Node ◽

Neoadjuvant Chemotherapy ◽

Lymph Nodes ◽

Axillary Lymph Node ◽

Radioactive Iodine ◽

Pathological Response ◽

Axillary Lymph Nodes ◽

Axillary Lymph ◽

Node Dissection ◽

Iodine 125

196 Background: An important benefit of neoadjuvant chemotherapy (NAC) is the increase in breast-conserving surgery. At present the response of axillary lymph node metastases to chemotherapy cannot be accurately assessed. Therefore axilla-conserving therapy is not yet a benefit. We aimed to assess a new surgical method to evaluate the axillary response: the MARI procedure, which stands for Marking of the Axillary lymph node with Radioactive Iodine seeds. Methods: Prior to NAC, proven tumor-positive axillary lymph nodes were marked with a Iodine-125 seed. After NAC, the marked lymph node was selectively removed with the use of a gamma-detection probe. A complementary axillary lymph node dissection was performed to assess whether pathological response in the marked node was indicative for the pathological response in the additional lymph nodes. Results: Tumor-positive axillary lymph nodes were successfully marked with Iodine-125 seeds in 68 patients. The marked lymph node (MARI-node) was surgically detected and selectively removed after NAC in all patients. The pathological response to chemotherapy in the MARI-node was indicative for the overall response in the additionally removed lymph nodes. In 47 patients the MARI-node contained residual disease (n=45 macrometastasis, n= 2 ITC). Thirty-five of them had macro- or micro metastases in the complementary axillary lymph node dissection specimen. In 21 patients the MARI-node was tumor negative. In 2 patients a macro metastasis was found in the additionally removed nodes, in 2 patients ITC were found and in the remaining 17 patients no residual tumor was found in the additionaly removed lymphnodes. (false negative rate of the MARI procedure: 9.5%). Conclusions: This study shows that marking and selectively removing metastatic lymph nodes after NAC is feasible. The tumor-response in the marked lymph node may be used to tailor further axillary treatment, and herewith enabling axilla-conserving surgery after neoadjuvant chemotherapy.

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