MR spectroscopy and diffusion tensor imaging of the brain in congenital muscular dystrophy with merosin deficiency: Metabolite level decreases, fractional anisotropy decreases, and apparent diffusion coefficient increases in the white matter

2007 ◽  
Vol 29 (5) ◽  
pp. 317-321 ◽  
Author(s):  
P.E. Sijens ◽  
J.M. Fock ◽  
L.C. Meiners ◽  
J.H. Potze ◽  
R. Irwan ◽  
...  
Keyword(s):  
Diffusion Coefficient ◽  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Diffusion Tensor ◽  
Congenital Muscular Dystrophy ◽  
Metabolite Level ◽  
Apparent Diffusion ◽  
The Brain ◽  
And Diffusion ◽  
Merosin Deficiency

scholarly journals Diffusion Tensor Imaging to Predict Long-term Outcome after Cardiac Arrest

2012 ◽  
Vol 117 (6) ◽  
pp. 1311-1321 ◽  
Author(s):  
Charles-Edouard Luyt ◽  
Damien Galanaud ◽  
Vincent Perlbarg ◽  
Audrey Vanhaudenhuyse ◽  
Robert D. Stevens ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Diffusion Coefficient ◽  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Apparent Diffusion Coefficient ◽  
Diffusion Tensor ◽  
Brain Magnetic Resonance Imaging ◽  
Unfavorable Outcome ◽  
Resonance Imaging ◽  
Apparent Diffusion

Background Prognostication in comatose survivors of cardiac arrest is a major clinical challenge. The authors' objective was to determine whether an assessment with diffusion tensor imaging, a brain magnetic resonance imaging sequence, increases the accuracy of 1 yr functional outcome prediction in cardiac arrest survivors. Methods Prospective, observational study in two intensive care units. Fifty-seven comatose survivors of cardiac arrest underwent brain magnetic resonance imaging. Fractional anisotropy (FA), a diffusion tensor imaging value, was measured in predefined white matter regions, and apparent diffusion coefficient was assessed in predefined grey matter regions. Prediction of unfavorable outcome at 1 yr was compared using four prognostic models: FA global, FA selected, apparent diffusion coefficient, and clinical classifiers. Results Of the 57 patients included in the study, 49 had an unfavorable outcome at 12 months. Areas under the receiver operating characteristic curve (95% CI) to predict unfavorable outcome for the FA global, FA selected, clinical, and apparent diffusion coefficient models were 0.92 (0.82-0.98), 0.96 (0.87-0.99), 0.78 (0.65-0.88), and 0.86 (0.74-0.94), respectively. The FA selected model had the best overall accuracy for predicting outcome, with a score above 0.44 having 94% (95% CI, 83-99%) sensitivity and 100% (95% CI, 63-100%) specificity for the prediction of unfavorable outcome. Conclusion Quantitative diffusion tensor imaging indicates that white matter damage is widespread after cardiac arrest. A prognostic model based on FA values in selected white matter tracts seems to predict accurately 1 yr functional outcome. These preliminary results need to be confirmed in a larger population.

Diffusion Tensor Imaging with Three-dimensional Fiber Tractography of Traumatic Axonal Shearing Injury: An Imaging Correlate for the Posterior Callosal “Disconnection” Syndrome: Case Report

Neurosurgery ◽  
2005 ◽  
Vol 56 (1) ◽  
pp. E195-E201 ◽  
Author(s):  
Tuong H. Le ◽  
Pratik Mukherjee ◽  
Roland G. Henry ◽  
Jeffrey I. Berman ◽  
Marcus Ware ◽  
...  
Keyword(s):  
Diffusion Coefficient ◽  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Magnetic Resonance ◽  
Diffusion Tensor ◽  
Three Dimensional ◽  
Magnetic Resonance Images ◽  
Fiber Tractography ◽  
Disconnection Syndrome ◽  
Apparent Diffusion

Abstract OBJECTIVE: To demonstrate that magnetic resonance diffusion tensor imaging (DTI) with three-dimensional (3-D) fiber tractography can visualize traumatic axonal shearing injury that results in posterior callosal disconnection syndrome. METHODS: A 22-year-old man underwent serial magnetic resonance imaging 3 days and 12 weeks after blunt head injury. The magnetic resonance images included whole-brain DTI acquired with a single-shot spin echo echoplanar sequence. 3-D DTI fiber tractography of the splenium of the corpus callosum was performed. Quantitative DTI parameters, including apparent diffusion coefficient and fractional anisotropy, from the site of splenial injury were compared with those of a normal adult male volunteer. RESULTS: Conventional magnetic resonance images revealed findings of diffuse axonal injury, including a lesion at the midline of the splenium of the corpus callosum. DTI performed 3 days posttrauma revealed that the splenial lesion had reduced apparent diffusion coefficient and fractional anisotropy, reflecting a large decrease in the magnitude of diffusion parallel to the white matter fibers, which had partially recovered as revealed by follow-up DTI 12 weeks postinjury. 3-D tractography revealed an interruption of the white matter fibers in the posteroinferior aspect of the splenium that correlated with the patient's left hemialexia, a functional deficit caused by disconnection of the right visual cortex from the language centers of the dominant left hemisphere. CONCLUSION: DTI with 3-D fiber tractography can visualize acute axonal shearing injury, which may have prognostic value for the cognitive and neurological sequelae of traumatic brain injury.

Diffusion tensor imaging reveals microstructural differences between subtypes of trigeminal neuralgia

2020 ◽  
Vol 133 (2) ◽  
pp. 573-579 ◽  
Author(s):  
Matthew S. Willsey ◽  
Kelly L. Collins ◽  
Erin C. Conrad ◽  
Heather A. Chubb ◽  
Parag G. Patil
Keyword(s):  
Diffusion Coefficient ◽  
Diffusion Tensor Imaging ◽  
Trigeminal Neuralgia ◽  
Apparent Diffusion Coefficient ◽  
Diffusion Tensor ◽  
Statistical Significance ◽  
Region Of Interest ◽  
Pain Syndrome ◽  
Radial Diffusivity ◽  
Apparent Diffusion

OBJECTIVETrigeminal neuralgia (TN) is an uncommon idiopathic facial pain syndrome. To assist in diagnosis, treatment, and research, TN is often classified as type 1 (TN1) when pain is primarily paroxysmal and episodic or type 2 (TN2) when pain is primarily constant in character. Recently, diffusion tensor imaging (DTI) has revealed microstructural changes in the symptomatic trigeminal root and root entry zone of patients with unilateral TN. In this study, the authors explored the differences in DTI parameters between subcategories of TN, specifically TN1 and TN2, in the pontine segment of the trigeminal tract.METHODSThe authors enrolled 8 patients with unilateral TN1, 7 patients with unilateral TN2, and 23 asymptomatic controls. Patients underwent DTI with parameter measurements in a region of interest within the pontine segment of the trigeminal tract. DTI parameters were compared between groups.RESULTSIn the pontine segment, the radial diffusivity (p = 0.0049) and apparent diffusion coefficient (p = 0.023) values in TN1 patients were increased compared to the values in TN2 patients and controls. The DTI measures in TN2 were not statistically significant from those in controls. When comparing the symptomatic to asymptomatic sides in TN1 patients, radial diffusivity was increased (p = 0.025) and fractional anisotropy was decreased (p = 0.044) in the symptomatic sides. The apparent diffusion coefficient was increased, with a trend toward statistical significance (p = 0.066).CONCLUSIONSNoninvasive DTI analysis of patients with TN may lead to improved diagnosis of TN subtypes (e.g., TN1 and TN2) and improve patient selection for surgical intervention. DTI measurements may also provide insights into prognosis after intervention, as TN1 patients are known to have better surgical outcomes than TN2 patients.

scholarly journals White matter and schizophrenia: A meta-analysis of voxel-based morphometry and diffusion tensor imaging studies

2017 ◽  
Vol 270 ◽  
pp. 8-21 ◽  
Author(s):  
Enrico Vitolo ◽  
Mona Karina Tatu ◽  
Claudia Pignolo ◽  
Franco Cauda ◽  
Tommaso Costa ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Diffusion Tensor ◽  
Meta Analysis ◽  
Voxel Based Morphometry ◽  
Imaging Studies ◽  
And Diffusion
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