Clinical characteristics of latent classes of CO 2 hypersensitivity in adolescents and young adults

e21043 Background: Melanoma is the third most common cancer among adolescents and young adults (AYAs; aged 15-39). Disease characteristics have not been well-described in this age group, particularly among diverse populations. We describe clinical features of AYAs diagnosed with melanoma at a large public hospital serving an ethnically diverse population. Methods: We reviewed medical chart data from patients diagnosed with melanoma between 2001-2016 at Los Angeles County + USC Medical Center. We describe clinical characteristics of AYA patients and compare to non-AYAs (aged ≥40) using Fisher’s exact test. A p-value < 0.05 was considered statistically significant. Results: Of the 273 melanoma patients identified, 47 (17.3%) were AYAs (mean age 32.3; SD±4.45; lower age range 18). The majority of patients were Hispanic (AYA, 53.2%; non-AYA, 51.1%), followed by non-Hispanic whites (AYA, 38.3%; non-AYA, 38.7%). A greater proportion of AYA patients were female (59.6%) compared to non-AYAs (38.2%) (p < 0.01). No AYA patients reported prior skin cancer compared to 19.9% of non-AYAs; 8.5% of AYAs reported family history of melanoma compared to 6.3% of non-AYAs. For all patients, superficial spreading melanoma was the most common histological subtype (AYA, 21.3%; non-AYA, 20.9%). Nodular melanoma was the second most common subtype in AYAs (17.02%) in contrast to acral lentiginous melanoma among non-AYAs (20.9%). Median Breslow depth was 3.0 mm for AYAs and 2.55 mm among non-AYAs. A slightly higher percentage of AYAs were diagnosed with regional disease (31.9%) than non-AYAs (24.4%), and a greater proportion of non-AYAs presented with distant metastases (AYA, 6.4%; non-AYA, 18.7%). The most common site of diagnosis were the extremities for all patients (AYA, 45.0%; non-AYA, 29.3%). Conclusions: We found similar clinical characteristics between AYA and non-AYA melanoma patients. However, we found a statistically significant difference for gender. The increased incidence of melanoma in female AYAs may be driven by biological factors such as sex hormones or genotype, or tanning behaviors. Further research is warranted to identify predictive and prognostic factors of melanoma among diverse AYAs, particularly females.

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P276 Predicting latent classes of food allergy risk-taking behaviors among adolescents and young adults

Annals of Allergy Asthma & Immunology ◽

10.1016/j.anai.2016.09.289 ◽

2016 ◽

Vol 117 (5) ◽

pp. S104

Author(s):

C. Warren ◽

A. Dyer ◽

B. Smith ◽

R. Gupta

Keyword(s):

Young Adults ◽

Food Allergy ◽

Risk Taking ◽

Adolescents And Young Adults ◽

Latent Classes ◽

Risk Taking Behaviors

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Osteosarcoma in Adolescents and Young Adults

Cells ◽

10.3390/cells10102684 ◽

2021 ◽

Vol 10 (10) ◽

pp. 2684

Author(s):

Jun Ah Lee ◽

Jiwon Lim ◽

Hye Young Jin ◽

Meerim Park ◽

Hyeon Jin Park ◽

...

Keyword(s):

Young Adults ◽

Young Children ◽

Clinical Characteristics ◽

Local Treatment ◽

Age Groups ◽

The Elderly ◽

Adolescents And Young Adults ◽

Dependent Manner ◽

Female Ratio ◽

Male To Female

The epidemiology of osteosarcoma in adolescents and young adults (AYA) remains unclear. We aimed to assess and compare the clinical features of osteosarcoma between AYA and other age groups. We retrieved osteosarcoma cases diagnosed between 1999 and 2017 from the Korea Central Cancer Registry. We compared survival trends and clinical characteristics between AYA and other age groups. AYA comprised 43.3% (1309/3022) of the osteosarcoma cases. Compared to other age groups, the male-to-female ratio was highest in AYA (1.61:1). The proportion of tumors located in an extremity was 80.3% in AYA, which was lower than in young children (92.5%) or pubertal children (93.8%) but higher than in adults (55.7%) or the elderly (47.5%). As for treatments, 71.2% of AYA received local treatment and systemic chemotherapy, and 28.8% received only local treatment (surgery: 261, radiotherapy: 9, surgery and radiotherapy: 5). The 5-year overall survival (OS) was lower in AYA (68%) than in young children (78%) or pubertal children (73%) but higher than in adults (47%) or the elderly (25%). When AYA were divided into five subgroups by age, patients aged 15–19 years constituted the largest proportion (45.4%, n = 594). Additionally, the proportion of patients with a non-extremity tumor increased in an age-dependent manner, from 10.3% in AYA aged 15–19 years to 35.3% in AYA aged 35–39 years. OS did not significantly differ among the different age subgroups of AYA. The clinical characteristics and OS of the AYA were more similar to those of children than to those of adults. There is a need for cooperation between pediatric and adult oncologists for effective osteosarcoma treatment in AYA.

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Erratum: Correction of Affiliations in the Article “Clinical Characteristics and Treatment Outcomes in Children, Adolescents, and Young-adults with Hodgkin's Lymphoma: a KPHOG Lymphoma Working-party, Multicenter, Retrospective Study”

Journal of Korean Medical Science ◽

10.3346/jkms.2021.36.e37 ◽

2021 ◽

Vol 36 (4) ◽

Author(s):

Jae Min Lee ◽

Jung Yoon Choi ◽

Kyung Taek Hong ◽

Hyoung Jin Kang ◽

Hee Young Shin ◽

...

Keyword(s):

Young Adults ◽

Retrospective Study ◽

Treatment Outcomes ◽

Hodgkin’S Lymphoma ◽

Clinical Characteristics ◽

Working Party ◽

Adolescents And Young Adults ◽

Hodgkin's Lymphoma

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Epidemiological and clinical characteristics of COVID-19 in adolescents and young adults

10.1101/2020.03.10.20032136 ◽

2020 ◽

Cited By ~ 14

Author(s):

Jiaqiang Liao ◽

Shibing Fan ◽

Jing Chen ◽

Jianglin Wu ◽

Shunqing Xu ◽

...

Keyword(s):

Young Adults ◽

Incubation Period ◽

Clinical Characteristics ◽

Family Members ◽

Kidney Injury ◽

Ground Glass Opacity ◽

Adolescents And Young Adults ◽

Adolescent And Young Adult ◽

Serial Interval

AbstractBackgroundAdolescents and young adults might play a key role in the worldwide spread of Coronavirus Disease 2019 (COVID-19), because they are more involved in overseas studying, business, working, and travelling. However, the epidemiological and clinical characteristics of them are still unknown.MethodsWe collected data of 46 confirmed COVID-19 patients aged 10 to 35 years from the study hospital. The demographics, epidemiological, and clinical data were collected. Several key epidemiological parameters, the asymptomatic cases and transmission to their family members and the clinical characteristics at admission, and during treatment were summarized.RESULTSOf 46 confirmed patients, 14 patients (47.3%) were aged from 10 to 24 years, and 24 (52.7%) patients were male. The mean incubation period for symptomatic cases was 6.6 days (95% confidence interval (CI) 4.4 - 9.6). The median serial interval was 1.9 days (95% CI 0.4 - 6.2). Three of asymptomatic cases showed the transmission to their family members. Only 1 patient was identified as severe cases at admission. The common symptoms at admission were dry cough (34, 91.0%), and fever (29, 69.0%). Nearly 60% of the patients had showed ground-glass opacity by chest CT findings. Three patients developed acute kidney injury during treatment. Majority of patients (78.3%) were discharged by the end of the follow-up.ConclusionsThe adolescent and young adult patients of COVID-19 had a long incubation period, and a short serial interval. The transmission to their family contactors occurred in asymptomatic cases. Few of the study patients have developed complications during treatment.

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