scholarly journals Epidemiological and Clinical Characteristics of COVID-19 in Adolescents and Young Adults

2020 ◽  
Vol 1 (1) ◽  
pp. 100001 ◽  
Author(s):  
Jiaqiang Liao ◽  
Shibing Fan ◽  
Jing Chen ◽  
Jianglin Wu ◽  
Shunqing Xu ◽  
...  
Keyword(s):  
Young Adults ◽  
Clinical Characteristics ◽  
Adolescents And Young Adults

Clinical characteristics of melanoma in an ethnically diverse population of adolescents and young adults.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e21043-e21043
Author(s):  
Kimberly Ann Miller ◽  
Anthony Pham ◽  
Jacob Stephen Thomas ◽  
Myles G Cockburn ◽  
David Robert Freyer ◽  
...  
Keyword(s):  
Young Adults ◽  
Los Angeles ◽  
Clinical Characteristics ◽  
Ethnically Diverse ◽  
Adolescents And Young Adults ◽  
P Value ◽  
Diverse Population ◽  
Acral Lentiginous Melanoma ◽  
Significant Difference ◽  
Melanoma Patients

e21043 Background: Melanoma is the third most common cancer among adolescents and young adults (AYAs; aged 15-39). Disease characteristics have not been well-described in this age group, particularly among diverse populations. We describe clinical features of AYAs diagnosed with melanoma at a large public hospital serving an ethnically diverse population. Methods: We reviewed medical chart data from patients diagnosed with melanoma between 2001-2016 at Los Angeles County + USC Medical Center. We describe clinical characteristics of AYA patients and compare to non-AYAs (aged ≥40) using Fisher’s exact test. A p-value < 0.05 was considered statistically significant. Results: Of the 273 melanoma patients identified, 47 (17.3%) were AYAs (mean age 32.3; SD±4.45; lower age range 18). The majority of patients were Hispanic (AYA, 53.2%; non-AYA, 51.1%), followed by non-Hispanic whites (AYA, 38.3%; non-AYA, 38.7%). A greater proportion of AYA patients were female (59.6%) compared to non-AYAs (38.2%) (p < 0.01). No AYA patients reported prior skin cancer compared to 19.9% of non-AYAs; 8.5% of AYAs reported family history of melanoma compared to 6.3% of non-AYAs. For all patients, superficial spreading melanoma was the most common histological subtype (AYA, 21.3%; non-AYA, 20.9%). Nodular melanoma was the second most common subtype in AYAs (17.02%) in contrast to acral lentiginous melanoma among non-AYAs (20.9%). Median Breslow depth was 3.0 mm for AYAs and 2.55 mm among non-AYAs. A slightly higher percentage of AYAs were diagnosed with regional disease (31.9%) than non-AYAs (24.4%), and a greater proportion of non-AYAs presented with distant metastases (AYA, 6.4%; non-AYA, 18.7%). The most common site of diagnosis were the extremities for all patients (AYA, 45.0%; non-AYA, 29.3%). Conclusions: We found similar clinical characteristics between AYA and non-AYA melanoma patients. However, we found a statistically significant difference for gender. The increased incidence of melanoma in female AYAs may be driven by biological factors such as sex hormones or genotype, or tanning behaviors. Further research is warranted to identify predictive and prognostic factors of melanoma among diverse AYAs, particularly females.

scholarly journals Clinical characteristics of latent classes of CO 2 hypersensitivity in adolescents and young adults

2017 ◽  
Vol 93 ◽  
pp. 95-103 ◽  
Author(s):  
Lance M. Rappaport ◽  
Christina Sheerin ◽  
Jeanne E. Savage ◽  
John M. Hettema ◽  
Roxann Roberson-Nay
Keyword(s):  
Young Adults ◽  
Clinical Characteristics ◽  
Adolescents And Young Adults ◽  
Latent Classes

scholarly journals Osteosarcoma in Adolescents and Young Adults

Cells ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 2684
Author(s):  
Jun Ah Lee ◽  
Jiwon Lim ◽  
Hye Young Jin ◽  
Meerim Park ◽  
Hyeon Jin Park ◽  
...  
Keyword(s):  
Young Adults ◽  
Young Children ◽  
Clinical Characteristics ◽  
Local Treatment ◽  
Age Groups ◽  
The Elderly ◽  
Adolescents And Young Adults ◽  
Dependent Manner ◽  
Female Ratio ◽  
Male To Female

The epidemiology of osteosarcoma in adolescents and young adults (AYA) remains unclear. We aimed to assess and compare the clinical features of osteosarcoma between AYA and other age groups. We retrieved osteosarcoma cases diagnosed between 1999 and 2017 from the Korea Central Cancer Registry. We compared survival trends and clinical characteristics between AYA and other age groups. AYA comprised 43.3% (1309/3022) of the osteosarcoma cases. Compared to other age groups, the male-to-female ratio was highest in AYA (1.61:1). The proportion of tumors located in an extremity was 80.3% in AYA, which was lower than in young children (92.5%) or pubertal children (93.8%) but higher than in adults (55.7%) or the elderly (47.5%). As for treatments, 71.2% of AYA received local treatment and systemic chemotherapy, and 28.8% received only local treatment (surgery: 261, radiotherapy: 9, surgery and radiotherapy: 5). The 5-year overall survival (OS) was lower in AYA (68%) than in young children (78%) or pubertal children (73%) but higher than in adults (47%) or the elderly (25%). When AYA were divided into five subgroups by age, patients aged 15–19 years constituted the largest proportion (45.4%, n = 594). Additionally, the proportion of patients with a non-extremity tumor increased in an age-dependent manner, from 10.3% in AYA aged 15–19 years to 35.3% in AYA aged 35–39 years. OS did not significantly differ among the different age subgroups of AYA. The clinical characteristics and OS of the AYA were more similar to those of children than to those of adults. There is a need for cooperation between pediatric and adult oncologists for effective osteosarcoma treatment in AYA.

scholarly journals Epidemiological and clinical characteristics of COVID-19 in adolescents and young adults

2020 ◽  
Author(s):  
Jiaqiang Liao ◽  
Shibing Fan ◽  
Jing Chen ◽  
Jianglin Wu ◽  
Shunqing Xu ◽  
...  
Keyword(s):  
Young Adults ◽  
Incubation Period ◽  
Clinical Characteristics ◽  
Family Members ◽  
Kidney Injury ◽  
Ground Glass Opacity ◽  
Adolescents And Young Adults ◽  
Adolescent And Young Adult ◽  
Serial Interval

AbstractBackgroundAdolescents and young adults might play a key role in the worldwide spread of Coronavirus Disease 2019 (COVID-19), because they are more involved in overseas studying, business, working, and travelling. However, the epidemiological and clinical characteristics of them are still unknown.MethodsWe collected data of 46 confirmed COVID-19 patients aged 10 to 35 years from the study hospital. The demographics, epidemiological, and clinical data were collected. Several key epidemiological parameters, the asymptomatic cases and transmission to their family members and the clinical characteristics at admission, and during treatment were summarized.RESULTSOf 46 confirmed patients, 14 patients (47.3%) were aged from 10 to 24 years, and 24 (52.7%) patients were male. The mean incubation period for symptomatic cases was 6.6 days (95% confidence interval (CI) 4.4 - 9.6). The median serial interval was 1.9 days (95% CI 0.4 - 6.2). Three of asymptomatic cases showed the transmission to their family members. Only 1 patient was identified as severe cases at admission. The common symptoms at admission were dry cough (34, 91.0%), and fever (29, 69.0%). Nearly 60% of the patients had showed ground-glass opacity by chest CT findings. Three patients developed acute kidney injury during treatment. Majority of patients (78.3%) were discharged by the end of the follow-up.ConclusionsThe adolescent and young adult patients of COVID-19 had a long incubation period, and a short serial interval. The transmission to their family contactors occurred in asymptomatic cases. Few of the study patients have developed complications during treatment.

scholarly journals Genomic Features and Clinical Characteristics of Adolescents and Young Adults With Cholangiocarcinoma

2020 ◽  
Vol 9 ◽  
Author(s):  
Hao Feng ◽  
Huan Tong ◽  
Jiayan Yan ◽  
Min He ◽  
Wei Chen ◽  
...  
Keyword(s):  
Young Adults ◽  
Clinical Characteristics ◽  
Adolescents And Young Adults ◽  
Genomic Features

Clinical characteristics and outcome of mycosis fungoides among children, adolescents, and young adults: Single institution study.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e19576-e19576
Author(s):  
Eric Taylor ◽  
Yumeng Zhang ◽  
Madeline Hooper ◽  
Lucia Seminario-Vidal ◽  
Lubomir Sokol
Keyword(s):  
Young Adults ◽  
Clinical Outcome ◽  
Children And Adolescents ◽  
Mycosis Fungoides ◽  
Clinical Characteristics ◽  
Early Stage ◽  
Age At Diagnosis ◽  
Adolescents And Young Adults ◽  
Medium Size ◽  
Female Ratio

e19576 Background: Mycosis fungoides (MF) is the most common subtype of cutaneous T cell lymphoma (CTCL) [1]. MF is characterized by the skin infiltrate of small to medium size T lymphocytes with cerebriform nuclei. The incidence of MF increases significantly with age, with a median age at diagnosis of 60 years, and predominantly in white males [2]. The clinical outcome has not been evaluated among children, adolescents, and young adults. This study aimed to evaluate the characteristics and outcomes in this population. Methods: We retrospectively reviewed clinical data on 90 patients with MF at Moffitt Cancer Center between 2000 and 2020. Fifteen patients were diagnosed before the age of 20 years. Our cohort was compared to the largest US epidemiological report by Nath et al. using SEER database, which consists of 4892 patients from 1998-2008 [2]. The Chi-square test was used for comparison. Overall survival (OS) was calculated from diagnosis until death or last contact. OS between different groups was compared using the Kaplan-Meier curve. Hazard ratio and p-value were calculated using the log-rank test. Results: Of 90 patients, the median age at diagnosis was 32 years (range 6-39). The male to female ratio was 1.3:1. White and black races account for 57% and 27% of the patients. Compared to historical control, black patients were significantly higher in the current cohort (27% vs. 13%, p < 0.001). The difference widened in children and adolescents. More patients present with early stage MF in the current cohort (95.6% vs. 83%, p = 0.003). Clinical characteristics, including stage, LDH, WBC, ferritin level, were similar between children/adolescents and young adults. However, our cohort had significantly higher CD8 positive MF, and nearly half of children and adolescents were CD8 positive. Young adults had a higher rate of coexisting skin malignancy; however, this was not statistically significant due to small patient size. Time to diagnosis remained long, especially in children and adolescents’ group. However, the outcome is excellent. At a median follow-up of 4.9 years, four patients deceased, and the median OS was not reached. The prognosis remains poor in patients with advanced disease (HR = 39, p < 0.001) and large cell transformation (LCT) (HR = 8.5, p = 0.009). Conclusions: Compared to historical cohorts, higher proportion of black and female patients were noted in our young cohort with more early-stage and CD8 positive disease. This observation likely represents the different underlying biology of the disease [3]. Clinical outcome in young patients was excellent. However, patients with LCT or advanced stage carry a poor prognosis and need better therapies.

Sign in / Sign up

Export Citation Format

Share Document