scholarly journals Predicting long term outcomes of deep brain stimulation in obsessive compulsive disorder, depression, and anorexia nervosa

2021 ◽  
Vol 14 (6) ◽  
pp. 1728
Author(s):  
Roel Mocking ◽  
Ilse Graat ◽  
Marloes Oudijn ◽  
Isidoor Bergfeld ◽  
Martijn Figee ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Deep Brain Stimulation ◽  
Obsessive Compulsive Disorder ◽  
Brain Stimulation ◽  
Long Term Outcomes ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Deep Brain

scholarly journals Deep Brain Stimulation for Major Depression and Obsessive-Compulsive Disorder—Discontinuation of Ongoing Stimulation

Psych ◽  
2020 ◽  
Vol 2 (3) ◽  
pp. 174-185
Author(s):  
Hannah M. Kilian ◽  
Bettina H. Bewernick ◽  
Margaretha Klein ◽  
Dora M. Meyer ◽  
Susanne Spanier ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Obsessive Compulsive Disorder ◽  
Brain Stimulation ◽  
Term Treatment ◽  
Obsessive Compulsive ◽  
Double Blind ◽  
Compulsive Disorder ◽  
Long Term Treatment ◽  
Deep Brain

Deep brain stimulation (DBS) is currently under research for the treatment of psychiatric disorders, e.g., obsessive-compulsive disorder (OCD) and treatment-resistant depression (TRD). Since the application of DBS in psychiatry has been in use for about 20 years, it is necessary to evaluate its long-term use now. A main issue in the long-term treatment of DBS concerns the effects of a discontinuation of stimulation due to intended as well as unintended reasons. In this contribution, the literature describing discontinuation effects following DBS in OCD and TRD is reviewed. Furthermore, a patient is reported in depth who experienced an unintended discontinuation of supero-lateral medial forebrain bundle (slMFB) DBS for TRD. In this case, the battery was fully depleted without the patient noticing. DBS had led to a sustained response for seven years before discontinuation of stimulation for just several weeks caused a progressive worsening of depression. Altogether, the rapid occurrence of symptom worsening, the absence of a notification about the stimulation status and the difficulties to recapture antidepressant response represent important safety aspects. For a further understanding of the described effects, time courses until worsening of depression as well as biological mechanisms need to be investigated in double-blind controlled trials.

Long-term follow-up of deep brain stimulation for refractory obsessive-compulsive disorder

2012 ◽  
Vol 200 (2-3) ◽  
pp. 1067-1070 ◽  
Author(s):  
Daeyoung Roh ◽  
Won Seok Chang ◽  
Jin Woo Chang ◽  
Chan-Hyung Kim
Keyword(s):  
Deep Brain Stimulation ◽  
Obsessive Compulsive Disorder ◽  
Brain Stimulation ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Long Term Follow Up ◽  
Deep Brain

scholarly journals Long-Term Deep-Brain Stimulation Treatment for Obsessive-Compulsive Disorder

2016 ◽  
Vol 77 (01) ◽  
pp. 132-133 ◽  
Author(s):  
Jon E. Grant ◽  
Brian L. Odlaug ◽  
Samuel R. Chamberlain
Keyword(s):  
Deep Brain Stimulation ◽  
Obsessive Compulsive Disorder ◽  
Brain Stimulation ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Deep Brain

scholarly journals Four-six year clinical follow-up of deep brain stimulation for obsessive compulsive disorder

BJPsych Open ◽  
2021 ◽  
Vol 7 (S1) ◽  
pp. S56-S56
Author(s):  
Himanshu Tyagi
Keyword(s):  
Deep Brain Stimulation ◽  
Obsessive Compulsive Disorder ◽  
Brain Stimulation ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Severity Scores ◽  
Long Term Follow Up ◽  
Deep Brain

BackgroundOver the past 20 years a number of robust studies have established the clinical effectiveness and safety of Deep brain stimulation (DBS) in adults with profound multi-treatment-refractory obsessive-compulsive disorder (OCD). However long term (>12 months) outcomes with this novel neurosurgical intervention are still inadequately reported. Our group conducted the first UK study of DBS in OCD between 2013-2017. All participants in our trial achieved a responder status at 15 month endpoint and the main results were reported in 2019. A specialist multidisciplinary clinic was established after the trial to provide life-long aftercare in the form of scheduled clinical and hardware reviews. Here we are reporting a preliminary analysis of the long-term clinical, functional and social outcomes from this cohort.MethodLong term follow-up clinical data (15–75 months, 2015 onwards) were prospectively collected from the participants who were enrolled in the original MRC-UCL pilot study of DBS for OCD. DBS parameters, battery health and status, social circumstances, mental state and medication adjustments were noted alongside the outcome measures of YBOCS at clinical follow-up encounters. Additional ratings of GAF, SDS and certain qualitative measures were recorded at least once every year since initial study completion.ResultFive out of six participants continued with DBS treatment and kept responder status. One participant had his DBS switched off and hardware removed. One participant had multiple hospital admissions to manage comorbidity progression to primary condition. One participant had OCD severity scores revised upwards despite continuing gains in QoL. Secondary outcomes generally matched the 15 month end point of initial trial. All participants experienced minor to major changes in their relationships with partners or family. Qualitative feedback indicated that DBS was well tolerated by 5/6 subjects but the burden of specialist follow-up remained significant.ConclusionOur long term follow-up data indicate that DBS is safe and conferred a sustained long-term benefit in reduction of obsessive-compulsive symptoms. A non-trivial burden of checking and maintenance of implanted hardware, comorbidity-unmasking following successful OCD treatment, perceived ‘burden of normality’ by the participant, need for life-long follow-ups with specialist multidisciplinary team including DBS nurses, highly specialist psychiatrists from National OCD service, neuropsychiatrists, neurologists and neurosurgeons partially counterbalances the gains offered by this treatment. Overall DBS offers a safe, effective and enduring alternative to participants who do not respond to any other form of OCD treatment and do not wish to undergo ablation surgery.

scholarly journals Deep Brain Stimulation for Obsessive–Compulsive Disorder: A Long Term Naturalistic Follow Up Study in a Single Institution

2020 ◽  
Vol 11 ◽  
Author(s):  
Marshall T. Holland ◽  
Nicholas T. Trapp ◽  
Laurie M. McCormick ◽  
Francis J. Jareczek ◽  
Mario Zanaty ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Obsessive Compulsive Disorder ◽  
Brain Stimulation ◽  
Single Institution ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Follow Up Study ◽  
Deep Brain

scholarly journals Improving long term patient outcomes from deep brain stimulation for treatment-refractory obsessive-compulsive disorder

2019 ◽  
Vol 20 (1) ◽  
pp. 95-107 ◽  
Author(s):  
Andrew Guzick ◽  
Patrick J. Hunt ◽  
Kelly R. Bijanki ◽  
Sophie C. Schneider ◽  
Sameer A. Sheth ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Obsessive Compulsive Disorder ◽  
Patient Outcomes ◽  
Brain Stimulation ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Treatment Refractory ◽  
Deep Brain
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