Fucoxanthin and its deacetylated product, fucoxanthinol, induce apoptosis of primary effusion lymphomas

2011 ◽  
Vol 300 (2) ◽  
pp. 225-234 ◽  
Author(s):  
Kei Yamamoto ◽  
Chie Ishikawa ◽  
Harukata Katano ◽  
Takeshi Yasumoto ◽  
Naoki Mori
Keyword(s):  
Primary Effusion Lymphomas

Morphogenesis of HHV8 in Primary Human Dermal Microvascular Endothelium and Primary Effusion Lymphomas

2000 ◽  
Vol 24 (5) ◽  
pp. 291-300 ◽  
Author(s):  
Jan Marc Orenstein, ◽  
Dolores M. Ciufo, ◽  
J. Paul Zoeteweij, ◽  
Andrew Blauvelt, ◽  
Gary S. Hayward
Keyword(s):  
Microvascular Endothelium ◽  
Primary Effusion Lymphomas

scholarly journals Viral and cellular cytokines in AIDS-related malignant lymphomatous effusions

Blood ◽  
2000 ◽  
Vol 96 (4) ◽  
pp. 1599-1601 ◽  
Author(s):  
Yoshiyasu Aoki ◽  
Robert Yarchoan ◽  
James Braun ◽  
Aikichi Iwamoto ◽  
Giovanna Tosato
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Human Immunodeficiency Virus ◽  
Potential Role ◽  
Kaposi Sarcoma ◽  
Enzyme Linked Immunosorbent Assay ◽  
Vascular Endothelial ◽  
Immunodeficiency Virus ◽  
Endothelial Growth Factor ◽  
Primary Effusion Lymphomas

Abstract Kaposi sarcoma-associated herpesvirus encodes viral IL-6 (vIL-6). To investigate the potential role of vIL-6 in the pathogenesis of human immunodeficiency virus (HIV)- related primary effusion lymphomas (PEL), a sensitive enzyme-linked immunosorbent assay was developed for vIL-6 and applied to the study of PEL. Whereas vIL-6 was detectable in 6 of 8 PEL effusions (range, 1390-66 630 pg/mL), it was not detectable in any of the control effusions. As expected, all PEL effusions contained human IL-6 (range, 957-37 494 pg/mL), and 7 of 8 contained detectable human IL-10 (range, 66-2,521,297 pg/mL). Human and vIL-6 have previously been shown to induce vascular endothelial growth factor, which in turn can increase vascular permeability. The results of the current study suggest that these cytokines play a central role in the pathogenesis and manifestations of PEL.

scholarly journals EXPRESSION OF KSHV/HHV 8 CYCLIN IN PRIMARY EFFUSION LYMPHOMAS AND KAPOSI'S SARCOMA

1997 ◽  
Vol 14 (4) ◽  
pp. A25 ◽  
Author(s):  
Roland G. Nador ◽  
Patricia Tsang ◽  
Jon A. Reed ◽  
Leandros Arvanitakis ◽  
Daniel M. Knowles ◽  
...  
Keyword(s):  
Kaposi's Sarcoma ◽  
Kaposi’S Sarcoma ◽  
Primary Effusion Lymphomas

Role of Vascular Endothelial Growth Factor/Vascular Permeability Factor in the Pathogenesis of Kaposi's Sarcoma-Associated Herpesvirus-Infected Primary Effusion Lymphomas

Blood ◽  
1999 ◽  
Vol 94 (12) ◽  
pp. 4247-4254 ◽  
Author(s):  
Yoshiyasu Aoki ◽  
Giovanna Tosato
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Vascular Permeability ◽  
Cell Lines ◽  
Kaposi's Sarcoma ◽  
Vascular Endothelial ◽  
Vascular Permeability Factor ◽  
Permeability Factor ◽  
Endothelial Growth Factor ◽  
Primary Effusion Lymphomas

Abstract Primary effusion lymphomas (PELs), which are rare lymphomas associated with Kaposi's sarcoma-associated herpesvirus (or human herpesvirus-8) infection, present as malignant lymphomatous effusions in body cavities. Because PELs prefer liquid growth, we hypothesized that increased vascular permeability would be required for effusions to form. We found that the PEL cell lines BC-1, BCP-1, and BCBL-1 produce high levels of vascular endothelial growth factor/vascular permeability factor (VEGF/VPF). Reverse transcriptase-polymerase chain reaction analysis of RNA from the PEL cell lines amplified the 3 VEGF-secreted isoforms: VEGF/VPF121, VEGF/VPF145, and VEGF/VPF165. Two of the PEL cell lines expressed the VEGF/VPF receptor Flt-1, but VEGF/VPF did not stimulate proliferation in these cells. Most (13/14) control SCID/beige mice inoculated intraperitoneally with BCBL-1 cells and subsequently observed or treated with control antibodies developed effusion lymphoma of human cell origin with prominent bloody ascites. In contrast, none (0/9) of the mice treated with a neutralizing antihuman VEGF/VPF antibody developed ascites and effusion lymphoma. These results demonstrate that VEGF/VPF is critical to BCBL-1 growth as effusion lymphoma in mice and suggest that VEGF/VPF stimulation of vascular permeability may be critical to the pathogenesis of PELs.

scholarly journals KSHV vFLIP Is Essential for the Survival of Infected Lymphoma Cells

2004 ◽  
Vol 199 (7) ◽  
pp. 993-1003 ◽  
Author(s):  
Ilaria Guasparri ◽  
Shannon A. Keller ◽  
Ethel Cesarman
Keyword(s):  
Interleukin 1 ◽  
Nuclear Factor ◽  
Converting Enzyme ◽  
Inhibitory Protein ◽  
Enhanced Sensitivity ◽  
Latently Infected ◽  
Induction Of Apoptosis ◽  
Primary Effusion Lymphomas ◽  
Cellular Flip ◽  
Infected Tumor

Primary effusion lymphomas (PELs) associated with infection by the Kaposi's sarcoma–associated herpesvirus (KSHV/HHV-8) have constitutive nuclear factor (NF)–κB activity that is essential for their survival, but the source of this activity is unknown. We report that viral FADD-like interleukin-1-β–converting enzyme [FLICE/caspase 8]-inhibitory protein (FLIP) activates NF-κB more potently than cellular FLIP in B cells and that it is largely responsible for NF-κB activation in latently infected PEL cells. Elimination of vFLIP production in PEL cells by RNA interference results in significantly decreased NF-κB activity, down-regulation of essential NF-κB–regulated cellular prosurvival factors, induction of apoptosis, and enhanced sensitivity to external apoptotic stimuli. vFLIP is the first virally encoded gene shown to be essential for the survival of naturally infected tumor cells.

Detection of vascular endothelial growth factor in AIDS-related primary effusion lymphomas

Blood ◽  
2000 ◽  
Vol 95 (3) ◽  
pp. 1109-1110 ◽  
Author(s):  
Yoshiyasu Aoki ◽  
Giovanna Tosato ◽  
Yoshihiro Nambu ◽  
Aikichi Iwamoto ◽  
Robert Yarchoan
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor ◽  
Primary Effusion Lymphomas

scholarly journals Targeting of Prosurvival Pathways as Therapeutic Approaches against Primary Effusion Lymphomas: Past, Present, and Future

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Marisa Granato ◽  
Roberta Santarelli ◽  
Roberta Gonnella ◽  
Antonella Farina ◽  
Pankaj Trivedi ◽  
...  
Keyword(s):  
Cell Death ◽  
Dendritic Cell ◽  
B Cell ◽  
Cancer Cells ◽  
Side Effect ◽  
Cytotoxic Effect ◽  
Anticancer Therapy ◽  
Therapeutic Approaches ◽  
Potential Side Effect ◽  
Primary Effusion Lymphomas

Constitutively activated prosurvival pathways render cancer cells addicted to their effects. Consequently they turn out to be the Achilles’ heels whose inhibition can be exploited in anticancer therapy. Primary effusion lymphomas (PELs) are very aggressive non-Hodgkin’s B cell lymphomas, whose pathogenesis is strictly linked to Kaposi’s sarcoma herpesvirus (KSHV) infection. Here we summarized previous studies from our and other laboratories exploring the cytotoxic effect of drugs inhibiting the main prosurvival pathways activated in PEL cells. Moreover, the immunogenicity of cell death, in terms of dendritic cell (DC) activation and their potential side effect on DCs, is discussed.

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