15-Deoxy-Δ12,14-prostaglandin J2 activates PI3K-Akt signaling in human breast cancer cells through covalent modification of the tumor suppressor PTEN at cysteine 136

2018 ◽  
Vol 424 ◽  
pp. 30-45 ◽  
Author(s):  
Jinyoung Suh ◽  
Do-Hee Kim ◽  
Eun-Hee Kim ◽  
Sin-Aye Park ◽  
Jong-Min Park ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Akt Signaling ◽  
Covalent Modification ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Prostaglandin J2

scholarly journals Cucurbitacin D exhibits its anti-cancer effect in human breast cancer cells by inhibiting Stat3 and Akt signaling

2018 ◽  
Vol 16 ◽  
pp. 1721727X1775180 ◽  
Author(s):  
Jin Mo Ku ◽  
Se Hyang Hong ◽  
Hyo In Kim ◽  
Ye Seul Lim ◽  
Sol Ji Lee ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Akt Signaling ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
P53 Expression ◽  
Anti Cancer ◽  
Cucurbitacin D

Cucurbitacins are triterpenoids commonly found in Cucurbitaceae and Cruciferae and have long been used in traditional medicine. Cucurbitacins demonstrate anti-inflammatory and anti-cancer activities. We investigated whether cucurbitacin D affects viability in breast cancer cells and its mechanism of action. An MTT assay was used to measure the viability of breast cancer cells. Western blot analysis was used to measure the expression of various modulators, such as p-p53, p-Stat3, p-Akt, and p-NF-κB. Doxorubicin and cucurbitacin D affected the viability of MCF7, MDA-MB-231, and SKBR3 cells. Cucurbitacin D and doxorubicin increased p-p53 expression in MCF7, SKBR3, and MDA-MB-231 cells. Cucurbitacin D suppressed p-Akt, p-NF-κB, and p-Stat3 expression in MCF7, MDA-MB-231, and SKBR3 cells. Doxorubicin alone did not decrease p-Akt and p-Stat3 levels. Cucurbitacin D decreased p-NF-κB and p-Stat3 levels. Doxorubicin in combination with cucurbitacin D increased p-p53 levels and suppressed Akt, NF-κB, Stat3, and Bcl-2 expression more than cucurbitacin D alone. Our results clearly demonstrate that cucurbitacin D could be a useful compound for treating human breast cancer.

scholarly journals Differential tumor biological role of the tumor suppressor KAI1 and its splice variant in human breast cancer cells

Oncotarget ◽  
2018 ◽  
Vol 9 (5) ◽  
pp. 6369-6390 ◽  
Author(s):  
Julia Miller ◽  
Tobias F. Dreyer ◽  
Anne Sophie Bächer ◽  
Eva-Kathrin Sinner ◽  
Christine Heinrich ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Splice Variant ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Biological Role ◽  
Human Breast Cancer Cells ◽  
Human Breast
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