Synthesis, characterization, swelling and drug release behavior of semi-interpenetrating network hydrogels of sodium alginate and polyacrylamide

Biopolymers, in particular polysaccharides, have attracted considerable interest in the field of drug delivery due to their biodegradable and biocompatible nature. This study is focused on the preparation and characterization of drug delivery devices based on sodium alginate (SA) composite films with poly(sodium 4-styrenesulfonate) (PSS). The prepared composite films were characterized for the determination of physiochemical properties, molecular interactions, and drug release behavior. The possible intermolecular hydrogen bonding between SA and PSS was determined by ATR-FTIR spectroscopy. Surface characterization was done using AFM. Polymeric films consisted of pristine SA and PSS exhibited relatively uniform and flat surfaces. However, the composite films showed phase separation that became more prominent as the concentration of PSS in the composite films was increased up to 40% (w/w). The contact angle (CA) values, using deionized water as a function of time (s), were ranging from 74° to 90°, and a decrease in CA (64° to 76°) was recorded for each composite film till 40 s. These CA values revealed that all the composite films were hydrophobic. It was observed that as the concentration of PSS in the films increased, hydrophobicity slightly varied as compared to the blank films of SA and PSS. Maximum CA (89°) was shown by a composite film having SA/PSS (90/10). Ciprofloxacin hydrochloride monohydrate (CPX), a model drug, loaded in a suitable composite film (cross-linked with 0.3 M CaCl2 solution) and drug release was evaluated in pH 1.2 simulated gastric fluid (SGF) and pH 7.4 phosphate buffer saline (PBS) solution. In SGF, around 90% of the model drug was released in 110 min that was approximately 77% in the case of PBS. Therefore, it was concluded that a sustained drug release behavior was exhibited in SGF as compared to PBS solution. These results suggest that these films are a promising and may potentially be subjected to study further their drug delivery behavior in applications like wound dressing. [Formula: see text]

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Mechanistic Study on Hydration and Drug Release Behavior of Sodium Alginate Compacts

Drug Development and Industrial Pharmacy ◽

10.1080/03639040600943814 ◽

2007 ◽

Vol 33 (6) ◽

pp. 667-676 ◽

Cited By ~ 20

Author(s):

Lai Wah Chan ◽

Ai Ling Ching ◽

Celine Valeria Liew ◽

Paul Wan Sia Heng

Keyword(s):

Drug Release ◽

Sodium Alginate ◽

Mechanistic Study ◽

Release Behavior ◽

Drug Release Behavior

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Disulfide cross-linked nanospheres from sodium alginate derivative for inflammatory bowel disease: Preparation, characterization, and in vitro drug release behavior

Carbohydrate Polymers ◽

10.1016/j.carbpol.2012.01.020 ◽

2012 ◽

Vol 88 (2) ◽

pp. 663-669 ◽

Cited By ~ 40

Author(s):

Dan Chang ◽

Jing Lei ◽

Huiran Cui ◽

Na Lu ◽

Yanjuan Sun ◽

...

Keyword(s):

Inflammatory Bowel Disease ◽

Drug Release ◽

Sodium Alginate ◽

Bowel Disease ◽

Release Behavior ◽

In Vitro Drug Release ◽

Drug Release Behavior ◽

Inflammatory Bowel

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Examining the effect of bovine serum albumin on the properties and drug release behavior of β-lactoglobulin-derived amyloid fibril-based hydrogels

International Journal of Biological Macromolecules ◽

10.1016/j.ijbiomac.2021.06.003 ◽

2021 ◽

Vol 184 ◽

pp. 79-91

Author(s):

Su-Chun How ◽

Ta-Hsien Lin ◽

Chun-Chao Chang ◽

Steven S.-S. Wang

Keyword(s):

Bovine Serum Albumin ◽

Drug Release ◽

Serum Albumin ◽

Bovine Serum ◽

Amyloid Fibril ◽

Release Behavior ◽

Drug Release Behavior ◽

Β Lactoglobulin

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Nanoformulation and Evaluation of Oral Berberine-Loaded Liposomes

Molecules ◽

10.3390/molecules26092591 ◽

2021 ◽

Vol 26 (9) ◽

pp. 2591

Author(s):

Thuan Thi Duong ◽

Antti Isomäki ◽

Urve Paaver ◽

Ivo Laidmäe ◽

Arvo Tõnisoo ◽

...

Keyword(s):

Thin Film ◽

Drug Release ◽

Size Distribution ◽

Water Soluble ◽

Release Behavior ◽

Uniform Size ◽

Ethanol Injection ◽

Drug Release Behavior ◽

Poorly Water Soluble

Berberine (BBR) is a poorly water-soluble quaternary isoquinoline alkaloid of plant origin with potential uses in the drug therapy of hypercholesterolemia. To tackle the limitations associated with the oral therapeutic use of BBR (such as a first-pass metabolism and poor absorption), BBR-loaded liposomes were fabricated by ethanol-injection and thin-film hydration methods. The size and size distribution, polydispersity index (PDI), solid-state properties, entrapment efficiency (EE) and in vitro drug release of liposomes were investigated. The BBR-loaded liposomes prepared by ethanol-injection and thin-film hydration methods presented an average liposome size ranging from 50 nm to 244 nm and from 111 nm to 449 nm, respectively. The PDI values for the liposomes were less than 0.3, suggesting a narrow size distribution. The EE of liposomes ranged from 56% to 92%. Poorly water-soluble BBR was found to accumulate in the bi-layered phospholipid membrane of the liposomes prepared by the thin-film hydration method. The BBR-loaded liposomes generated by both nanofabrication methods presented extended drug release behavior in vitro. In conclusion, both ethanol-injection and thin-film hydration nanofabrication methods are feasible for generating BBR-loaded oral liposomes with a uniform size, high EE and modified drug release behavior in vitro.

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