Mesalazine/hydroxypropyl-β-cyclodextrin/chitosan nanoparticles with sustained release and enhanced anti-inflammation activity

Objective: The objective of the present study was to develop sustained release biodegradable polymeric nanoparticles of rosuvastatin calcium. Methods: Nanoparticles were prepared by modified ionotropic gelation method using 3² full factorial designs. From the preliminary trials, the constraints for independent variables X1 (concentration. of chitosan) and X2 (concentration. of sodium tripolyphosphate) have been fixed. Factors included concentration of chitosan and sodium tripolyphosphate, have been examined to investigate effect on particle size, encapsulation efficiency, zeta potential, % release, scanning electron microscopy, Fourier transfer infrared study and X-ray diffraction and release study of rosuvastatin calcium nanoparticles. 0 Results: The prepared nanoparticles were white, free-flowing and spherical in shape. The infrared spectra showed stable character of rosuvastatin calcium in the drug-loaded nanoparticles and revealed the absence of drug polymer interactions. The chitosan nanoparticles have a particle diameter ranging approximately 114.5±3.61 to 724±.2.51 nm and a zeta potential-13.12 to-52.63 mV. The in vitro release behavior from all the drug loaded batches were found to follow first order and provided sustained release over a period of 10 h. The Zeta potential of all the batches were in the range of-13.12 to-52.63 mv. The release profiles of all batches were very well fitted by Korsmeyer Peppas model. Conclusion: The best-fit release kinetics was achieved with Korsmeyer peppas model. The release of rosuvastatin calcium was influenced by the drug to polymer ratio and particle size. These results indicate that rosuvastatin calcium nanoparticles could be effective in sustaining drug release for a prolonged period.

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Evaluation of in vitro release kinetics of Capsaicin-loaded chitosan nanoparticles using DDSolver

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v11i3.2685 ◽

2020 ◽

Vol 11 (3) ◽

pp. 4555-4559

Author(s):

Narissara Kulpreechanan ◽

Feuangthit Niyamissara Sorasitthiyanukarn

Keyword(s):

Gastrointestinal Tract ◽

Sustained Release ◽

Release Kinetics ◽

Chitosan Nanoparticles ◽

Circulatory System ◽

Fickian Diffusion ◽

Release Mechanism ◽

Release Study ◽

Kinetics Of

The present aim is to evaluate the release profile and its release kinetics of encapsulated capsaicin from chitosan nanoparticles using the software DDSolver. The release study was performed by using a dialysis technique in PBS solutions with different pHs (1.2, 6.8 and 7.4) to mimics the different gastrointestinal tract and circulatory system pH ranges as a releasing medium. The nanoparticles were prepared using o/w emulsification and ionotropic gelation technique under optimal condition obtained from response surface methodology (RSM) design as described in our previous study. These nanoparticles were around 180 nm in average hydrodynamic size and encapsulation efficiency percentage around 70%, respectively. In vitro drug release study suggested that the chitosan nanoparticles can potentially use to controlled and sustained release of capsaicin over at least 96. The kinetic release analysis results by DDSolver software indicated that Weibull model was suggested to be the best dynamic models with highest R2adjusted and model selection criteria (MSC) and lowest Akaike information criterion (AIC), respectively, for capsaicin loaded chitosan nanoparticles. The release mechanism of capsaicin from nanoparticles was found to be Fickian diffusion. The results suggest that the chitosan nanoparticles can be applied for the controlled and sustained release of capsaicin in the gastrointestinal tract and circulatory system.

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Dimethyl-β-cyclodextrin/salazosulfapyridine inclusion complex-loaded chitosan nanoparticles for sustained release

Carbohydrate Polymers ◽

10.1016/j.carbpol.2016.09.038 ◽

2017 ◽

Vol 156 ◽

pp. 215-222 ◽

Cited By ~ 13

Author(s):

Peixiao Tang ◽

Hongqin Yang ◽

Bin Tang ◽

Di Wu ◽

Qiaohong Du ◽

...

Keyword(s):

Inclusion Complex ◽

Sustained Release ◽

Chitosan Nanoparticles

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Chlorogenic acid loaded chitosan nanoparticles with sustained release property, retained antioxidant activity and enhanced bioavailability

Asian Journal of Pharmaceutical Sciences ◽

10.1016/j.ajps.2014.09.005 ◽

2015 ◽

Vol 10 (3) ◽

pp. 203-211 ◽

Cited By ~ 77

Author(s):

Ilaiyaraja Nallamuthu ◽

Aishwarya Devi ◽

Farhath Khanum

Keyword(s):

Antioxidant Activity ◽

Sustained Release ◽

Chlorogenic Acid ◽

Chitosan Nanoparticles ◽

Release Property

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Magnetic Alginate/Chitosan Nanoparticles for Targeted Delivery of Curcumin into Human Breast Cancer Cells

Nanomaterials ◽

10.3390/nano8110907 ◽

2018 ◽

Vol 8 (11) ◽

pp. 907 ◽

Cited By ~ 26

Author(s):

Wenxing Song ◽

Xing Su ◽

David Gregory ◽

Wei Li ◽

Zhiqiang Cai ◽

...

Keyword(s):

Cancer Therapy ◽

Sustained Release ◽

Cancer Cells ◽

Targeted Delivery ◽

Chitosan Nanoparticles ◽

Cancer Drug ◽

Breast Adenocarcinoma ◽

Uptake Efficiency ◽

Diphenyltetrazolium Bromide ◽

Hdf Cells

Curcumin is a promising anti-cancer drug, but its applications in cancer therapy are limited, due to its poor solubility, short half-life and low bioavailability. In this study, curcumin loaded magnetic alginate/chitosan nanoparticles were fabricated to improve the bioavailability, uptake efficiency and cytotoxicity of curcumin to Human Caucasian Breast Adenocarcinoma cells (MDA-MB-231). Alginate and chitosan were deposited on Fe3O4 magnetic nanoparticles based on their electrostatic properties. The nanoparticle size ranged from 120–200 nm, within the optimum range for drug delivery. Controllable and sustained release of curcumin was obtained by altering the number of chitosan and alginate layers on the nanoparticles. Confocal fluorescence microscopy results showed that targeted delivery of curcumin with the aid of a magnetic field was achieved. The fluorescence-activated cell sorting (FACS) assay indicated that MDA-MB-231 cells treated with curcumin loaded nanoparticles had a 3–6 fold uptake efficiency to those treated with free curcumin. The 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) assay indicated that the curcumin loaded nanoparticles exhibited significantly higher cytotoxicity towards MDA-MB-231 cells than HDF cells. The sustained release profiles, enhanced uptake efficiency and cytotoxicity to cancer cells, as well as directed targeting make MACPs promising candidates for cancer therapy.

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