Electrophysiological activity of a neurotoxic fraction from the venom of box jellyfish Carybdea marsupialis

Author(s):  
Fernando Lazcano-Pérez ◽  
Rogelio O. Arellano ◽  
Edith Garay ◽  
Roberto Arreguín-Espinosa ◽  
Judith Sánchez-Rodríguez

PLoS ONE ◽  
2015 ◽  
Vol 10 (9) ◽  
pp. e0137272 ◽  
Author(s):  
Cesar Bordehore ◽  
Verónica L. Fuentes ◽  
Jose G. Segarra ◽  
Melisa Acevedo ◽  
Antonio Canepa ◽  
...  


2011 ◽  
Vol 356 (1) ◽  
pp. 160-161
Author(s):  
Jenna Valley ◽  
Vicki Martin




2010 ◽  
Vol 24 (2) ◽  
pp. 131-135 ◽  
Author(s):  
Włodzimierz Klonowski ◽  
Pawel Stepien ◽  
Robert Stepien

Over 20 years ago, Watt and Hameroff (1987 ) suggested that consciousness may be described as a manifestation of deterministic chaos in the brain/mind. To analyze EEG-signal complexity, we used Higuchi’s fractal dimension in time domain and symbolic analysis methods. Our results of analysis of EEG-signals under anesthesia, during physiological sleep, and during epileptic seizures lead to a conclusion similar to that of Watt and Hameroff: Brain activity, measured by complexity of the EEG-signal, diminishes (becomes less chaotic) when consciousness is being “switched off”. So, consciousness may be described as a manifestation of deterministic chaos in the brain/mind.



Nature ◽  
2005 ◽  
Author(s):  
Michael Hopkin
Keyword(s):  


2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S75-S75
Author(s):  
Pia Enager ◽  
Nikolas Offenhauser ◽  
Martin Lauritzen


1992 ◽  
Vol 156 (9) ◽  
pp. 655-658 ◽  
Author(s):  
Christopher E Beadnell ◽  
Timothy A Rider ◽  
John A Williamson ◽  
Peter J Fenner


2019 ◽  
Vol 40 (4) ◽  
pp. 808-822 ◽  
Author(s):  
Maximilian Böhm ◽  
David Y Chung ◽  
Carlos A Gómez ◽  
Tao Qin ◽  
Tsubasa Takizawa ◽  
...  

Neurovascular coupling is a fundamental response that links activity to perfusion. Traditional paradigms of neurovascular coupling utilize somatosensory stimulation to activate the primary sensory cortex through subcortical relays. Therefore, examination of neurovascular coupling in disease models can be confounded if the disease process affects these multisynaptic pathways. Optogenetic stimulation is an alternative to directly activate neurons, bypassing the subcortical relays. We employed minimally invasive optogenetic cortical activation through intact skull in Thy1-channelrhodopsin-2 transgenic mice, examined the blood flow changes using laser speckle imaging, and related these to evoked electrophysiological activity. Our data show that optogenetic activation of barrel cortex triggers intensity- and frequency-dependent hyperemia both locally within the barrel cortex (>50% CBF increase), and remotely within the ipsilateral motor cortex (>30% CBF increase). Intriguingly, activation of the barrel cortex causes a small (∼10%) but reproducible hypoperfusion within the contralateral barrel cortex, electrophysiologically linked to transhemispheric inhibition. Cortical spreading depression, known to cause neurovascular uncoupling, diminishes optogenetic hyperemia by more than 50% for up to an hour despite rapid recovery of evoked electrophysiological activity, recapitulating a unique feature of physiological neurovascular coupling. Altogether, these data establish a minimally invasive paradigm to investigate neurovascular coupling for longitudinal characterization of cerebrovascular pathologies.



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