Serum ionic fluoride concentrations are significantly decreased after treatment with alendronate in patients with osteoporosis

The serum ionic fluoride concentrations in 497 normal individuals, from areas with non-fluoridated water supplies, ranged from 0·25 to 2·20 μmol F−/l and were positively correlated with age (r = 0·31, p<0·001). Distribution of the data with age, coupled with the distribution of serum calcium with age, suggests a possible change in bone metabolism between 26 and 35 years of age. Serum fluoride levels vary with the time of day with a mean minimum value at 0800 and a mean peak value at 2200. Renal clearance studies gave fluoride ion clearances ranging from 19·5 to 44·0 ml/min and tubular reabsorption of fluoride ion ranging from 61·5 to 86·5%. After oral ingestion of 0·48 mmol sodium fluoride, peak serum levels occurred at 60 to 90 minutes; the peak levels were significantly higher in women than in men.

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Serum ionic fluoride concentrations are related to renal function and menopause status but not to age in a Japanese general population

Clinica Chimica Acta ◽

10.1016/j.cca.2009.11.014 ◽

2010 ◽

Vol 411 (3-4) ◽

pp. 263-266 ◽

Cited By ~ 7

Author(s):

Kazuyoshi Itai ◽

Toshiyuki Onoda ◽

Masaru Nohara ◽

Masaki Ohsawa ◽

Kozo Tanno ◽

...

Keyword(s):

Renal Function ◽

General Population ◽

Ionic Fluoride ◽

Japanese General Population

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Determination of Total and Ionic Fluoride in Formula Milk Produced in Japan.

JOURNAL OF DENTAL HEALTH ◽

10.5834/jdh.42.316 ◽

1992 ◽

Vol 42 (3) ◽

pp. 316-323 ◽

Cited By ~ 1

Author(s):

Misako TOMITA ◽

Takako SUGIMURA ◽

Masahide KOYAMA ◽

Yoshihiro KANEKO

Keyword(s):

Formula Milk ◽

Ionic Fluoride

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Studies on Determination of Ionic Fluoride in Serum.

JOURNAL OF DENTAL HEALTH ◽

10.5834/jdh.44.125 ◽

1994 ◽

Vol 44 (1) ◽

pp. 125-127

Author(s):

Koji HARA ◽

Kazuaki KAWAMURA ◽

Asako YAMAZAKI ◽

Yoshikazu IIZUKA

Keyword(s):

Ionic Fluoride

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Vertebral Osteoporosis: Relationship of Serum Ionic Fluoride to Vitamin D Metabolites during Therapy

Clinical Science ◽

10.1042/cs091013p ◽

1996 ◽

Vol 91 (s35) ◽

pp. 13P-13P

Author(s):

TJ Hine ◽

JG Middle ◽

NB Roberts ◽

WH Taylor

Keyword(s):

Vitamin D ◽

Vitamin D Metabolites ◽

Vertebral Osteoporosis ◽

Ionic Fluoride ◽

Relationship Of

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A micro method for direct determination of ionic fluoride in body fluids with the hanging drop fluoride electrode

Clinica Chimica Acta ◽

10.1016/0009-8981(75)90002-9 ◽

1975 ◽

Vol 59 (3) ◽

pp. 277-282 ◽

Cited By ~ 29

Author(s):

P. Venkateswarlu

Keyword(s):

Direct Determination ◽

Body Fluids ◽

Hanging Drop ◽

Ionic Fluoride ◽

Fluoride Electrode

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Concentrations of ionic, total, and bound fluoride in plasma.

Clinical Chemistry ◽

10.1093/clinchem/25.4.523 ◽

1979 ◽

Vol 25 (4) ◽

pp. 523-525 ◽

Cited By ~ 28

Author(s):

L Singer ◽

R H Ophaug

Keyword(s):

Age Groups ◽

Fluoride Concentration ◽

Older Age ◽

Male And Female ◽

Ionic Fluoride ◽

Younger Age ◽

Significant Difference ◽

The Mean ◽

Female Subjects

Abstract We found no significant difference between the means for ionic, bound, and total fluoride concentrations in the plasma of male and female subjects of the same age, living in a community with fluoridated water. When results for the 264 fasting subjects were therefore combined according to age, they indicated that persons over 60 years of age have a significantly higher mean ionic (3.89 mumol/L) and total (6.58 mumol/L) fluoride concentration in plasma than do younger age groups. For younger age groups, means ranged from 2.74 to 3.05 mumol/L for ionic fluoride and from 4.74 to 5.58 mumol/L for total. The bound fluoride concentration was lower in individuals 21 to 30 years of age (1.89 mumol/L) than in older age groups (for whom means ranged from 2.42 to 2.68 mumol/L), but was not significantly different from that of individuals who were younger (2.21 mumol/L). A tendency for the mean ionic fluoride concentration to increase with age was noted, but the concentration was significantly higher than the preceding decade group only in those persons over 60 years of age.

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