The haptoglobin promoter polymorphism rs5471 is the most definitive genetic determinant of serum haptoglobin level in a Ghanaian population

2018 ◽  
Vol 483 ◽  
pp. 303-307 ◽  
Author(s):  
Mikiko Soejima ◽  
Kwesi Teye ◽  
Yoshiro Koda
Keyword(s):  
Promoter Polymorphism ◽  
Genetic Determinant ◽  
Serum Haptoglobin ◽  
Haptoglobin Level

Genetic factors associated with serum haptoglobin level in a Japanese population

2014 ◽  
Vol 433 ◽  
pp. 54-57 ◽  
Author(s):  
Mikiko Soejima ◽  
Noriaki Sagata ◽  
Nobukazu Komatsu ◽  
Tetsuro Sasada ◽  
Atsushi Kawaguchi ◽  
...  
Keyword(s):  
Japanese Population ◽  
Genetic Factors ◽  
Factors Associated ◽  
Serum Haptoglobin ◽  
Haptoglobin Level

scholarly journals Evaluation of the influence of transport and adaptation stress on chosen immune and oxidative parameters and occurrence of respiratory syndrome in feedlot calves

2014 ◽  
Vol 58 (1) ◽  
pp. 111-116
Author(s):  
Andrzej Wernicki ◽  
Renata Urban-Chmiel ◽  
Andrzej Puchalski ◽  
Marta Dec
Keyword(s):  
Weight Gain ◽  
Acute Phase Proteins ◽  
Thiobarbituric Acid ◽  
Daily Weight Gain ◽  
Feed Consumption ◽  
Behavioural Disorders ◽  
Serum Haptoglobin ◽  
Behavioural Activity ◽  
Haptoglobin Level ◽  
Feedlot Calves

AbstractImmune and oxidative parameters were evaluated as indicators of the influence of stress on the occurrence of respiratory syndrome in feedlot calves. The study was carried out on 60 2 and a half-month-old Simmentaler calves transported at feedlot. Mean daily feed consumption, daily weight gain, and behavioural activity were evaluated. Blood was collected on days 1, 3, 7, 14, 21, and 28 of feedlot. Serum NO ions, lipid peroxidation, acute phase proteins, IgG, and IgM were determined. The calves showed a decrease in feed consumption during the first 7 d of the feedlot. Sporadic stereotypies were noted. NO concentration showed a significant (P < 0.05) increase on days 7 and 14. Concentration of thiobarbituric acid reactive substances (TBARS) increased (P < 0.05) on days 1 and 3. IgM concentration was found to be considerably lower on days 14 and 28. Serum haptoglobin level showed a significant increase in stressed calves on days 1, 3, 7, and 14 of the feedlot. Based on these results, it can be suggested that stressors associated with transport and adaptation to the feedlot induce a stress reaction in calves, resulting in behavioural disorders, reduced weight gain, suppression of the humoral immunity and increased morbidity during the first weeks. These parameters seem to be crucial in evaluating the animals' health and welfare.

scholarly journals Changes of Serum Haptoglobin Level before and during Open Heart Surgery.

1992 ◽  
Vol 21 (2) ◽  
pp. 109-116 ◽  
Author(s):  
Tsuyoshi SHIMIZU ◽  
Sin ISHIMARU ◽  
Kinichi FURUKAWA ◽  
Tatsuhiko KUDO
Keyword(s):  
Heart Surgery ◽  
Open Heart Surgery ◽  
Open Heart ◽  
Serum Haptoglobin ◽  
Haptoglobin Level

Acute-phase responses in cattle infected with hydatid cysts and microbial agents

2014 ◽  
Vol 89 (4) ◽  
pp. 471-479 ◽  
Author(s):  
A. Sevimli ◽  
F.K. Sevimli ◽  
E. Şeker ◽  
A. Ulucan ◽  
H.H. Demirel
Keyword(s):  
Acute Phase ◽  
Microbial Growth ◽  
Common Species ◽  
Control Group ◽  
Infected Cattle ◽  
Hydatid Cysts ◽  
Amyloid A ◽  
Serum Haptoglobin ◽  
Haptoglobin Level ◽  
Microbial Agents

AbstractThe aim of this study was to investigate the effect of hydatid cysts and microbial agents on the acute-phase response in cattle. Twenty-seven cattle with hydatid cysts and eight apparently healthy cattle comprised the study and control groups, respectively. Parasitological, microbiological, histopathological and immunohistochemical examinations of the liver and lungs were undertaken, and 49 of these organs were infected with cysts. In 14 of 31 (45.1%) livers and 10 of 18 (55.5%) lungs microbial growth was observed. The most frequent species occurring in the liver were Staphylococcus aureus, Escherichia coli, Corynebacterium spp. and Campylobacter spp., whereas in the lungs the most common species was Candida spp., followed by Streptococcus spp., Mannheimia haemolytica, Corynebacterium spp., Micrococcus spp. and S. aureus. The concentration of serum interleukin (IL-6) in infected cattle, 455.35 ± 39.68 pg/ml, was significantly higher than that of 83.02 ± 17.87 pg/ml in the control group (P< 0.001). The serum amyloid A (SAA) level of infected cattle was 7.51 ± 0.41 μg/ml, and 4.84 ± 0.51 μg/ml in the control group (P< 0.001). The serum haptoglobin level of infected cattle was found to be 2.08 ± 0.65 ng/ml, while that of the control group was determined as 3.87 ± 0.91 ng/ml (P>0.05). The highest concentrations of IL-6 were detected in serum of the cattle where microbial growth had been detected, followed by cattle infected with bacteria + Trichostrongylus sp. (P< 0.001). Consequently, SAA showed an important increase in the group infected with hydatid cysts, whereas haptoglobin level decreased. It was noticed that IL-6, like SAA, had a significant role in hydatid cyst infection. Therefore IL-6 and SAA appear to be major markers in the detection of infection of cattle with hydatid cysts.

scholarly journals Studies on the Serum Haptoglobin Level in Hemoglobinemia and Its Influence on Renal Excretion of Hemoglobin

Blood ◽  
1957 ◽  
Vol 12 (6) ◽  
pp. 493-506 ◽  
Author(s):  
CARL-BERTIL LAURELL ◽  
MARGARETA NYMAN
Keyword(s):  
Intravenous Injection ◽  
Threshold Value ◽  
Free Hemoglobin ◽  
Electrophoretic Method ◽  
Serum Haptoglobin ◽  
Hemoglobin Binding ◽  
Constant Rate ◽  
Haptoglobin Level ◽  
Binding Power

Abstract A short survey is given of the literature on haptoglobin, the hemoglobin-binding serum protein, its properties and biologic variations. The principles of an electrophoretic method for quantitative determination of the serum haptoglobin are described. Electrophoretic studies showed that haptoglobin has a high affinity for hemoglobin at physiologic pH and that every haptoglobin molecule can bind at least 2 hemoglobin molecules. Observations made following the intravenous injection of hemoglobin showed: that hemoglobin administered intravenously is bound by the haptoglobin; that free hemoglobin is not demonstrable until more hemoglobin has been injected than can be bound by the haptoglobin; that the complex hemoglobin-haptoglobin is eliminated from the plasma after intravascular hemolysis or intravenous administration of hemoglobin without being excreted in the urine; that the hemoglobin-haptoglobin complex is removed from the plasma at a constant rate during the major part of the elimination period; that the haptoglobin level will fall to nil within 24 hours, if the amount of hemoglobin injected is sufficient to bind all the haptoglobin available. During the following days the rate of formation of haptoglobin can be studied. From the data available it can be concluded that hemoglobinuria cannot appear until the amount of hemoglobin administered intravenously or the amount liberated intravascularly exceeds the binding power of the haptoglobin and the reabsorption capacity of the tubules. The variation observed by earlier authors in the so-called renal threshold for hemoglobin on intravenous injection of hemoglobin can be explained among other things by the variation in the haptoglobin content in one and the same subject, i.e., if the haptoglobin level is low, the threshold value will also be low, and vice versa.

Effect of Blood Transfusion On Serum Haptoglobin.

Blood ◽  
2009 ◽  
Vol 114 (22) ◽  
pp. 3138-3138
Author(s):  
Shilpi Gupta ◽  
Fadi Nakhl ◽  
Kera Weiserbs ◽  
Frank J. Forte
Keyword(s):  
Conflicts Of Interest ◽  
Acute Phase Reactant ◽  
Normal Serum ◽  
Free Hemoglobin ◽  
Packed Red Blood Cells ◽  
Serum Haptoglobin ◽  
Haptoglobin Level ◽  
Larger Sample ◽  
Multiple Units ◽  
Stored Blood

Abstract Abstract 3138 Poster Board III-75 Introduction Haptoglobin, an alpha2 globulin, is an acute phase reactant, which functions to bind the globin portion of free hemoglobin in the blood. The half-life of serum haptoglobin is approximately five days, but in the presence of free hemoglobin, the hemoglobin-haptoglobin complex is rapidly cleared from the system causing a decrease in the measured serum haptoglobin (normal levels 36-195mg/dl). The measurement of serum haptoglobin is used as one of the laboratory markers for the diagnosis of hemolytic anemia. Since stored blood contains a variable amount of free hemoglobin, transfusion of this blood may affect haptoglobin levels and thereby negate the usefulness of haptoglobin measurement when hemolysis is suspected in recently transfused patients. Patients and methods Twenty-0ne patients, who were being transfused with more than one unit of packed red blood cells (PRBC), for non-hemolytic indications, were enrolled in the study and their serum haptoglobin levels were recorded before, immediately after, 24 hours after and 48 hours after PRBC transfusion. Observations and results A total of twenty-one patients were enrolled in the study and these patients received a total of forty-seven units of PRBC. The most common indication for transfusion was anemia secondary to blood loss. Eighteen patients received two units, one patient received three units, and two patients received four units of PRBC. Four patients received PRBC's that were more than 30 days old. When blood less than 30 days old was transfused there was a decrease to below normal in the haptoglobin level of only one patient, and this patient had a low normal serum haptoglobin level prior to transfusion. However, in four patients who received blood that was more than 30 days old, two (fifty percent) had a decrease in serum haptoglobin levels to below normal. Conclusion Serum haptoglobin can be used in the diagnosis of hemolysis in patients receiving multiple units of PRBC transfusions when the age of the transfused blood is less than thirty days. However, when PRBC's more than thirty days old are transfused measurement of serum haptoglobin might not prove to be a reliable indicator of hemolysis. Further studies with larger sample sizes are needed to confirm our findings. Disclosures No relevant conflicts of interest to declare.

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