Sedation and Weaning from Mechanical Ventilation: Linking Spontaneous Awakening Trials and Spontaneous Breathing Trials to Improve Patient Outcomes

One of the challenges in intensive care is the process of weaning from mechanical ventilation. We studied the differences in respiratory pattern variability between patients capable of maintaining spontaneous breathing during weaning trials, and patients that fail to maintain spontaneous breathing. In this work, neural networks were applied to study these differences. 64 patients from mechanical ventilation are studied: Group S with 32 patients with Successful trials, and Group F with 32 patients that Failed to maintain spontaneous breathing and were reconnected. A performance of 64.56% of well classified patients was obtained using a neural network trained with the whole set of 35 features. After the application of a feature selection procedure (backward selection) 84.25% was obtained using only eight of the 35 features.

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Distinguishing Features of the Kinetics of Oxygen Consumption During the Spontaneous Breathing Trials for Tracheostomized Patients with Prolonged Mechanical Ventilation

10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5444 ◽

2019 ◽

Author(s):

I.H. Lee ◽

F.-C. Lin ◽

J.-C. Cheng ◽

C.-K. Huang ◽

Y.-C. Chien ◽

...

Keyword(s):

Mechanical Ventilation ◽

Oxygen Consumption ◽

Spontaneous Breathing ◽

Prolonged Mechanical Ventilation ◽

Spontaneous Breathing Trials ◽

Kinetics Of ◽

Distinguishing Features

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Spontaneous Breathing Trials and Conservative Sedation Practices Reduce Mechanical Ventilation Duration in Subjects With ARDS

Respiratory Care ◽

10.4187/respcare.05270 ◽

2017 ◽

Vol 63 (1) ◽

pp. 1-10 ◽

Cited By ~ 5

Author(s):

Richard H Kallet ◽

Hanjing Zhuo ◽

Vivian Yip ◽

Antonio Gomez ◽

Michael S Lipnick

Keyword(s):

Mechanical Ventilation ◽

Spontaneous Breathing ◽

Ventilation Duration ◽

Mechanical Ventilation Duration ◽

Spontaneous Breathing Trials

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Failed Weaning from Mechanical Ventilation and Cardiac Dysfunction

Critical Care Research and Practice ◽

10.1155/2012/173527 ◽

2012 ◽

Vol 2012 ◽

pp. 1-6

Author(s):

Jahan Porhomayon ◽

Peter Papadakos ◽

Nader D. Nader

Keyword(s):

Mechanical Ventilation ◽

Cardiac Dysfunction ◽

Serum Biomarkers ◽

Weaning From Mechanical Ventilation ◽

Significant Morbidity ◽

Additional Information ◽

Controlled Mechanical Ventilation ◽

Timely Fashion ◽

Spontaneous Breathing Trials ◽

Weaning Outcome

Failure to transition patient from controlled mechanical ventilation to spontaneous breathing trials (SBTs) in a timely fashion is associated with significant morbidity and mortality in the intensive care unit. In addition, weaning failures are common in patients with limited cardiac reserves. Recent advances in cardiac echocardiography and laboratory measurement of serum biomarkers to assess hemodynamic response to SBT may provide additional information to guide clinicians to predict weaning outcome.

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