Dual Role of the Adaptive Immune System in Liver Injury and Hepatocellular Carcinoma Development

AbstractThe different roles of the adaptive immune system in cancer are beginning to unfold. The dramatic responses to immune check point drugs in some tumors generated an accelerated need for understanding the complex set of interactions between tumor and immune cells. In view of the major pathophysiological role of immune cells in hepatocellular carcinoma, it is not surprising that malignant hepatocytes interact extensively with adaptive immune cells, resulting in both protumor immunopathology and antitumor protective immunity. Identifying potential responders to drugs that target the adaptive immune system, monitoring their immune response to the tumor, and devising the best treatment combinations depends on understanding the complex set of interactions taking place within the tumor and in the adjacent hepatic parenchyma.

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Role of the Adaptive Immune System in Idiosyncratic Drug-Induced Liver Injury

Drug-Induced Liver Disease ◽

10.1016/b978-0-12-387817-5.00011-x ◽

2013 ◽

pp. 175-193 ◽

Cited By ~ 4

Author(s):

Jack Uetrecht

Keyword(s):

Immune System ◽

Liver Injury ◽

Adaptive Immune System ◽

Drug Induced ◽

Drug Induced Liver Injury ◽

Adaptive Immune

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Adipocytes, Innate Immunity and Obesity: A Mini-Review

Frontiers in Immunology ◽

10.3389/fimmu.2021.650768 ◽

2021 ◽

Vol 12 ◽

Author(s):

Alecia M. Blaszczak ◽

Anahita Jalilvand ◽

Willa A. Hsueh

Keyword(s):

Adipose Tissue ◽

Immune System ◽

Immune Cells ◽

Adaptive Immune System ◽

Innate Immune ◽

Lymphoid Cells ◽

Innate Immune Cells ◽

Adaptive Immune

The role of adipose tissue (AT) inflammation in obesity and its multiple related-complications is a rapidly expanding area of scientific interest. Within the last 30 years, the role of the adipocyte as an endocrine and immunologic cell has been progressively established. Like the macrophage, the adipocyte is capable of linking the innate and adaptive immune system through the secretion of adipokines and cytokines; exosome release of lipids, hormones, and microRNAs; and contact interaction with other immune cells. Key innate immune cells in AT include adipocytes, macrophages, neutrophils, and innate lymphoid cells type 2 (ILC2s). The role of the innate immune system in promoting adipose tissue inflammation in obesity will be highlighted in this review. T cells and B cells also play important roles in contributing to AT inflammation and are discussed in this series in the chapter on adaptive immunity.

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Role of immune cells in the ocular manifestations of pemphigoid diseases

Therapeutic Advances in Ophthalmology ◽

10.1177/2515841419868128 ◽

2019 ◽

Vol 11 ◽

pp. 251584141986812

Author(s):

Tanima Bose

Keyword(s):

Immune System ◽

Immune Cells ◽

Γδ T Cells ◽

Adaptive Immune System ◽

Mucous Membrane Pemphigoid ◽

Adaptive Immune ◽

Ocular Manifestations ◽

Different Types ◽

Ocular Distribution

Pemphigoid disease is classified according to the phenotypical location of the disease and the presence of different types of antibodies. The ocular distribution of pemphigoid mainly occurs in patients with bullous pemphigoid and mucous membrane pemphigoid. Several immune cells, including the cells of the innate immune system (neutrophils and γδ T cells) and the adaptive immune system (T and B cells), are involved in pemphigoid disease. The treatment of pemphigoid is still wide-ranging, and the most utilized treatment is the use of immunosuppressants and corticosteroids. In this scenario, it is absolutely important to screen the immune cells that are involved in this group of diseases and to determine if a targeted treatment approach is plausible. In conclusion, this review will identify some newer treatment possibilities for the whole spectrum of pemphigoid diseases.

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Role of the adaptive immune system in hypertension

Current Opinion in Pharmacology ◽

10.1016/j.coph.2010.01.006 ◽

2010 ◽

Vol 10 (2) ◽

pp. 203-207 ◽

Cited By ~ 108

Author(s):

David G Harrison ◽

Antony Vinh ◽

Heinrich Lob ◽

Meena S Madhur

Keyword(s):

Immune System ◽

Adaptive Immune System ◽

Adaptive Immune

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1040 INTERACTION OF THE INNATE AND ADAPTIVE IMMUNE SYSTEM CONTRIBUTE TO LIVER INJURY AND HEPATOCARCINOGENESIS

Journal of Hepatology ◽

10.1016/s0168-8278(13)61041-7 ◽

2013 ◽

Vol 58 ◽

pp. S427

Author(s):

J. Endig ◽

J. Schütt ◽

S. Marhenke ◽

L.E. Buitrago Molina ◽

R. Geffers ◽

...

Keyword(s):

Immune System ◽

Liver Injury ◽

Adaptive Immune System ◽

Adaptive Immune

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Role of T Lymphocytes in Type 2 Diabetes and Diabetes-Associated Inflammation

Journal of Diabetes Research ◽

10.1155/2017/6494795 ◽

2017 ◽

Vol 2017 ◽

pp. 1-6 ◽

Cited By ~ 52

Author(s):

Chang Xia ◽

Xiaoquan Rao ◽

Jixin Zhong

Keyword(s):

Insulin Resistance ◽

Type 2 Diabetes ◽

T Cells ◽

Immune System ◽

Critical Role ◽

Adaptive Immune System ◽

Metabolic Inflammation ◽

Adaptive Immune

Although a critical role of adaptive immune system has been confirmed in driving local and systemic inflammation in type 2 diabetes and promoting insulin resistance, the underlying mechanism is not completely understood. Inflammatory regulation has been focused on innate immunity especially macrophage for a long time, while increasing evidence suggests T cells are crucial for the development of metabolic inflammation and insulin resistance since 2009. There was growing evidence supporting the critical implication of T cells in the pathogenesis of type 2 diabetes. We will discuss the available effect of T cells subsets in adaptive immune system associated with the procession of T2DM, which may unveil several potential strategies that could provide successful therapies in the future.

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