Microneedle patch based on molecular motor as a spatio-temporal controllable dosing strategy of L-DOPA for Parkinson's disease

2021 ◽  
pp. 131555
Author(s):  
Xin Zhou ◽  
Bowen Li ◽  
Mingming Guo ◽  
Wenchang Peng ◽  
Deping Wang ◽  
...  
2018 ◽  
Vol 10 (2) ◽  
Author(s):  
Massimiliano Pau ◽  
Federica Corona ◽  
Roberta Pili ◽  
Carlo Casula ◽  
Marco Guicciardi ◽  
...  

This study aimed to investigate possible differences in spatio-temporal gait parameters of people with Parkinson’s Disease (pwPD) when they are tested either in laboratory using 3D Gait Analysis or in a clinical setting using wearable accelerometers. The main spatio-temporal gait parameters (speed, cadence, stride length, stance, swing and double support duration) of 31 pwPD were acquired: i) using a wearable accelerometer in a clinical setting while wearing shoes (ISS); ii) same as condition 1, but barefoot (ISB); iii) using an optoelectronic system (OES) undressed and barefoot. While no significant differences were found for cadence, stance, swing and double support duration, the experimental setting affected speed and stride length that decreased (by 17% and 12% respectively, P<0.005) when passing from the clinical (ISS) to the laboratory (OES) setting. These results suggest that gait assessment should be always performed in the same conditions to avoid errors, which may lead to inaccurate patient’s evaluations.


Author(s):  
Armando Coccia ◽  
Bernardo Lanzillo ◽  
Leandro Donisi ◽  
Federica Amitrano ◽  
Giuseppe Cesarelli ◽  
...  

2017 ◽  
Vol 8 (6) ◽  
pp. 583-586
Author(s):  
Donatas Lukšys ◽  
Julius Griškevičius

Parkinson’s disease – progressive neurologic disorder that damages a variety of motor function and reduces the quality of life. Patients with PD are subject to various physical therapy exercises, but recently is applied more often the dance – music therapy. This study aims assessing the therapeutic effect of the modified Lindy Hop dance therapy on lower extremity biomechanics. The experimental study was performed using inertial sensors that registered lower extremity biomechanical parameters during gait. Several spatio-temporal parameters of lower limb were calculated and were found statistically significant between groups, which allows quantifying the influence of dance therapy. Parkinsono liga (PL) – progresuojantis neurologinis sutrikimas, kuris pažeidžia įvairias motorines funkcijas ir sumažina gyvenimo kokybę. Sergant PL, taikomos įvairios fizinių pratimų terapijos, bet paskutiniu metu dažniau taikoma šokių – muzikos – terapija. Eksperimentinio tyrimo metu buvo naudojami inerciniai jutikliai, siekiant registruoti apatinių galūnių biomechaninius parametrus eisenos metu. Šio straipsnio tikslas – įvertinti modifikuotos lindihopo šokių terapijos įtaką apatinių galūnių biomechanikai. Buvo apskaičiuoti apatinių galūnių kinematiniai parametrai ir surasti statistiškai reikšmingi skirtumai tarp grupių ir grupių viduje, kurie leidžia kiekybiškai įvertinti šokių įtaką.


2020 ◽  
Author(s):  
Alessandro Grillini ◽  
Remco J. Renken ◽  
Anne C. L. Vrijling ◽  
Joost Heutink ◽  
Frans W. Cornelissen

AbstractEvaluating the state of the oculomotor system of a patient is one of the fundamental tests done in neuro-ophthalmology. However, up to date, very few quantitative standardized tests of eye movements quality exist, limiting this assessment to confrontational tests reliant on subjective interpretation. Furthermore, quantitative tests relying on eye movement properties such as pursuit gain and saccade dynamics are often insufficient to capture the complexity of the underlying disorders and are often (too) long and tiring. In this study, we present SONDA (Standardised Oculomotor and Neurological Disorder Assessment): this test is based on analyzing eye tracking recorded during a short and intuitive continuous tracking task. We tested patients affected by Multiple Sclerosis (MS) and Parkinson’s Disease (PD) and find that: (1) the saccadic dynamics of the main sequence alone are not sufficient to separate patients from healthy controls; (2) the combination of spatio-temporal and statistical properties of saccades and saccadic dynamics enables an identification of oculomotor abnormalities in both MS and PD patients. We conclude that SONDA constitutes a powerful screening tool that allows an in-depth evaluation of (deviant) oculomotor behavior in a few minutes of non-invasive testing.


2020 ◽  
Vol 79 ◽  
pp. 86-91
Author(s):  
Sergio Clavijo-Buendía ◽  
Francisco Molina-Rueda ◽  
Patricia Martín-Casas ◽  
Paulina Ortega-Bastidas ◽  
Esther Monge-Pereira ◽  
...  

2017 ◽  
Vol 381 ◽  
pp. 1042
Author(s):  
C.H. Tsai ◽  
H.C. Huang ◽  
B.L. Liu ◽  
H.C. Lin ◽  
M.K. Lu ◽  
...  

2018 ◽  
Vol 18 (08) ◽  
pp. 1840023 ◽  
Author(s):  
DO-YOUNG KWON ◽  
YOON-HYEOK CHOI ◽  
YU-RI KWON ◽  
GWANG-MOON EOM ◽  
JUNGHYUK KO ◽  
...  

Scans without evidence of dopaminergic deficit (SWEDD) refers to patients with a normal dopamine transporter scan among patients clinically diagnosed with Parkinson’s disease (PD). It is essential to differentiate SWEDD from PD in order to avoid costly and inappropriate treatments. We investigated differences of gait pattern in PD patients and SWEDD patients. Twelve patients with SWEDD and 8 patients with PD participated in the gait test. All participants were instructed to walk along the GaitRite linear walkway at comfortable velocity. As outcome measure, various spatio-temporal gait variables were derived from commercial GaitRite software. Independent sample [Formula: see text]-tests were evaluated to investigate statistical differences between SWEDD patients and PD patients. SWEDD patients walked more quickly with longer step length compared to PD patients ([Formula: see text]). PD patients exhibited a longer stance phase with increased double-limb support period than SWEDD patients ([Formula: see text]). Step time difference of SWEDD patients was smaller than that of PD patients ([Formula: see text]). These findings suggest quantitative gait variables could be helpful for the identification of potential SWEDD patients. Also, understanding of gait strategies of SWEDD patients might be contributed to their effective medications and treatments.


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