Discovery of a covalent inhibitor of heat shock protein 90 with antitumor activity that blocks the co-chaperone binding via C-terminal modification

2021 ◽  
Author(s):  
Li Li ◽  
Nannan Chen ◽  
Dandan Xia ◽  
Shicheng Xu ◽  
Wei Dai ◽  
...  
Keyword(s):  
Heat Shock ◽  
Antitumor Activity ◽  
Heat Shock Protein ◽  
Heat Shock Protein 90 ◽  
Chaperone Binding ◽  
Covalent Inhibitor

Abstract 3693: Preclinical antitumor activity of SST0116CL1, a novel heat shock protein 90 (HSP90) inhibitor

2014 ◽  
Author(s):  
Loredana Vesci ◽  
Ferdinando Milazzo ◽  
Valeria Carollo ◽  
Silvia Pace ◽  
Giuseppe Giannini
Keyword(s):  
Heat Shock ◽  
Antitumor Activity ◽  
Heat Shock Protein ◽  
Heat Shock Protein 90 ◽  
Hsp90 Inhibitor

scholarly journals Antitumor activity and molecular effects of the novel heat shock protein 90 inhibitor, IPI-504, in pancreatic cancer

2008 ◽  
Vol 7 (10) ◽  
pp. 3275-3284 ◽  
Author(s):  
Dongweon Song ◽  
Raghothama Chaerkady ◽  
Aik Choon Tan ◽  
Elena García-García ◽  
Anuradha Nalli ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Heat Shock ◽  
Antitumor Activity ◽  
Heat Shock Protein ◽  
Heat Shock Protein 90 ◽  
The Novel ◽  
Molecular Effects

scholarly journals SNX2112, a Synthetic Heat Shock Protein 90 Inhibitor, Has Potent Antitumor Activity against HER Kinase Dependent Cancers

2008 ◽  
Vol 14 (1) ◽  
pp. 240-248 ◽  
Author(s):  
S. Chandarlapaty ◽  
A. Sawai ◽  
Q. Ye ◽  
A. Scott ◽  
M. Silinski ◽  
...  
Keyword(s):  
Heat Shock ◽  
Antitumor Activity ◽  
Heat Shock Protein ◽  
Heat Shock Protein 90

scholarly journals Antitumor Activity of SNX-2112, a Synthetic Heat Shock Protein-90 Inhibitor, in MET-Amplified Tumor Cells with or without Resistance to Selective MET Inhibition

2011 ◽  
Vol 17 (1) ◽  
pp. 122-133 ◽  
Author(s):  
Thomas Bachleitner-Hofmann ◽  
Mark Y. Sun ◽  
Chin-Tung Chen ◽  
David Liska ◽  
Zhaoshi Zeng ◽  
...  
Keyword(s):  
Heat Shock ◽  
Antitumor Activity ◽  
Heat Shock Protein ◽  
Tumor Cells ◽  
Heat Shock Protein 90
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