scholarly journals Histopathological changes in Oreochromis mossambicus (Peters, 1852) ovaries after a chronic exposure to a mixture of the HIV drug nevirapine and the antibiotics sulfamethoxazole and trimethoprim

Chemosphere ◽  
2021 ◽  
Vol 274 ◽  
pp. 129900
Author(s):  
U.M.C. Nibamureke ◽  
G.M. Wagenaar
Keyword(s):  
Chronic Exposure ◽  
Oreochromis Mossambicus ◽  
Histopathological Changes

scholarly journals TINGKAT BIOKONSENTRASI LOGAM BERAT DAN GAMBARAN HISTOPATOLOGI IKAN MUJAIR (Oreochromis Mossambicus) YANG HIDUP DI PERAIRAN TUKAD BADUNG KOTA DENPASAR

2015 ◽  
Vol 9 (1) ◽  
pp. 25
Author(s):  
Made Rahayu Kusumadewi ◽  
I Wayan Budiarsa Suyasa ◽  
I Ketut Berata
Keyword(s):  
Heavy Metals ◽  
Heavy Metal ◽  
Hexavalent Chromium ◽  
Metal Contamination ◽  
Heavy Metal Contamination ◽  
Quality Standards ◽  
Oreochromis Mossambicus ◽  
Metal Exposure ◽  
Histopathological Changes ◽  
Food Ingredient

Tukad Badung River is one of the potential contamination of heavy metal sare very highin the city of Denpasar. Tilapia (Oreochromis mossambicus) isa commonspecies of fish found in the river and became the object of fishing by the public. The fish is usually consume das a food ingredient forever yangler. Fish can be used as bio-indicators of chemical contamination in the aquatic environment. Determination of heavy metal bioconcentration and analysis of liver histopathology gills organs and muscles is performed to determine the content of heavy metals Pb, Cd, and Cr+6, and the influence of heavy metal exposure to changes in organ histopathology Tilapia that live in Tukad Badung. In this observational study examined the levels of heavy metal contamination include Pb, Cd and Cr+6 in Tilapia meat with AAS method (Atomic Absorption Spectrofotometric), and observe the histopathological changes in organ preparations gills, liver, and muscle were stained with HE staining (hematoxylin eosin). Low Pb content of the fish that live in Tukad Badung 0.8385 mg/kg and high of 20.2600 mg/kg. The content of heavy metals Pb is above the quality standards specified in ISO 7378 : 2009 in the amount of 0.3 mg / kg. The content of Cr+6 low of 1.1402 mg / kg and the highest Cr+6 is 6.2214 mg / kg. The content of Cr+6 is above the quality standards established in the FAO Fish Circular 764 is equal to 1.0 mg / kg. In fish with Pb bioconcentration of 0.8385 mg / kg and Cr+6 of 1.1402 mg / kg was found that histopathological changes gill hyperplasia and fusion, the liver was found degeneration, necrosis, and fibrosis, and in muscle atrophy found. Histopathologicalchangessuch asedema and necrosis ofthe liveris foundin fishwith Pb bioconcentration of 4.5225mg/kg and Cr+6 amounted to2.5163mg/kg. Bio concentration of heavy metal contamination of lead (Pb) and hexavalent chromium (Cr+6) on Tilapia ( Oreochromis mossambicus ) who lives in Tukad Badung river waters exceed the applicable standard. Histopathological changes occur in organs gills, liver, and muscle as a result of exposure to heavy metals lead and hexavalent chromium. Advised the people not to eat Tilapia that live in Tukad Badung

Arsenic induced toxicity and histopathological changes in gill and liver tissue of freshwater fish, tilapia (Oreochromis mossambicus)

2013 ◽  
Vol 65 (6) ◽  
pp. 903-909 ◽  
Author(s):  
Md. Kawser Ahmed ◽  
Md. Habibullah-Al-Mamun ◽  
Elora Parvin ◽  
Mosammat Salma Akter ◽  
Mohammad Shahneawz Khan
Keyword(s):  
Freshwater Fish ◽  
Liver Tissue ◽  
Oreochromis Mossambicus ◽  
Histopathological Changes

Dermal Histology in Mouse Skin Exposed to Cosmeceuticals

2017 ◽  
Vol 33 (05) ◽  
pp. 545-550
Author(s):  
Hope Bueller ◽  
Yvonne Hsia ◽  
J. Thomas ◽  
Tapan Bhattacharyya
Keyword(s):  
Quantitative Data ◽  
Chronic Exposure ◽  
Glycolic Acid ◽  
Mouse Skin ◽  
Hairless Mouse ◽  
Dorsal Skin ◽  
Histopathological Changes ◽  
Over The Counter ◽  
Aging Populations ◽  
Skin Samples

AbstractChronic exposure to environmental ultraviolet radiation elicits deleterious photoaging changes and histopathological damage to the skin. In addition to cosmetic surgical procedures, over-the-counter products described as cosmeceuticals are widely used by a large segment of globally aging populations to partially reverse changes induced by photoaging. Many such products are rarely examined in the laboratory to examine their ameliorative properties and microscopic effects on various skin compartments. The hairless mouse is a popular animal model widely used over the last few decades by researchers to compare cosmeceuticals about their properties to combat or reverse cutaneous photoaging changes. In the present experiment, five cosmeceuticals were topically administered to the dorsal skin over 2 weeks in the nonirradiated mice, and skin samples were analyzed for dermal histopathological changes. Histomorphometric procedures were employed to generate quantitative data on skin sections prepared with immunohistochemistry and staining technics, and the data statistically examined. Among the five agents tested, glycolic acid and retinoic acid produced striking changes, while vitamin C, estrogen, and soy product resulted in less remarkable responses. These quantitative data will be useful for further photoaging studies with these cosmeceuticals.

Effects of Acute Toxicity of Chlorpyrifos (EC 50%) and Associated Histological Alterations in Gills, Liver and Kidney of Mozambique Tilapia, Oreochromis mossambicus (Peters, 1852)

2020 ◽  
Author(s):  
N. Jayakumar ◽  
A. Subburaj ◽  
P. Jawahar ◽  
A. Srinivasan ◽  
B. Ahilan
Keyword(s):  
Acute Toxicity ◽  
Oreochromis Mossambicus ◽  
The Body ◽  
Dependent Manner ◽  
Histopathological Changes ◽  
Aquatic Life ◽  
Histological Changes ◽  
Mozambique Tilapia ◽  
Secondary Lamellae ◽  
Liver And Kidney

Background: The pesticides are known to adversely affect the quality of water and create hazards for aquatic life that results in severe damage to non-target freshwater organisms including fish. Among them, the organophosphorus pesticide, chlorpyrifos (CPF) is one of the most commonly used pesticides for controlling various kinds of pests in agriculture. Pesticides after entering in to the body of fish bring about histopathological and biochemical changes in different target and non-target organs. Hence, the present study aimed to investigate the toxicity effects of Chlorpyrifos (CPF) and associated histopathological changes in the gill, liver and kidney of the Mozambique Tilapia, Oreochromis mossambicus under the acute toxicity concentrations. Methods: Static bioassay was carried out for Chlorpyrifos with Oreochromis mossambicus as test animal for a period of 96 hrs as per standard methods and LC50 values were calculated through Probit analysis. The fishes were exposed to five acute concentrations (0.033, 0.066, 0.132, 0.264 and 0.528 ppb). The gill, liver and kidney tissues were collected from the fishes exposed to the pesticide and standard histology protocol was followed to investigate the histopathological changes. Result: The histological changes observed in the gill included lamellar aneurysm, curling of secondary lamellae, shortening of the secondary lamellae, hypertrophy of epithelial cell, fusion of secondary lamellae, deformation of the cartilage core, blood congestion, collapsed secondary lamellae, excessive mucus secretion, disorganization of the secondary lamellae, haemorrhage at primary lamellae, necrosis, haemorrhage at secondary lamellae. The most common histopathological changes in the liver were characterized by cellular necrosis, degeneration of hepatocytes, nuclear degeneration, fat deposition, rupture of nucleus, hypertrophied hepatocytes, blood congestion, blood sinusoids, cellular hypertrophy, increased pycnotic nucleus, cirrhosis and hemosiderosis. Further, histological changes like appearance of dilated lumen, hypertrophied epithelial cells, severe haemorrhage, blood congestion, melanomacrophage aggregation, narrowing of lumen, degenerated tubule, degenerated glomerulus, shrunken glomerulus and distended glomerulus were observed in the kidney. Thus, it is evident from the present study that Chlorpyrifos can be a potential toxicant affecting the fishes at tissue level on dose and time dependent manner which are expected to affect the other physiological processes in the long run.

Histopathological changes and zootechnical performance in juvenile zebrafish (Danio rerio) under chronic exposure to nitrate

Aquaculture ◽  
2017 ◽  
Vol 473 ◽  
pp. 197-205 ◽  
Author(s):  
André Pereira ◽  
António Paulo Carvalho ◽  
Cristina Cruz ◽  
Aurélia Saraiva
Keyword(s):  
Danio Rerio ◽  
Chronic Exposure ◽  
Histopathological Changes

Histopathological Changes in Rabbit Gastric Mucosa After Chronic Exposure to Pickled Vegetables: An Experimental Study

2013 ◽  
Vol 65 (7) ◽  
pp. 1042-1044 ◽  
Author(s):  
Massood Hosseinzadeh ◽  
Navid Omidifar ◽  
Amir Reza Dehghanian ◽  
Perikala Vijayananda Kumar ◽  
Mohammad Hasan Meshkibaf
Keyword(s):  
Experimental Study ◽  
Gastric Mucosa ◽  
Chronic Exposure ◽  
Histopathological Changes ◽  
Pickled Vegetables

Chronic exposure to dichloroacetamide induces biochemical and histopathological changes in the gills of zebrafish

2019 ◽  
Vol 34 (7) ◽  
pp. 781-787 ◽  
Author(s):  
Yu Zhang ◽  
Hong‐Jie Sun ◽  
Jing‐Ying Zhang ◽  
Emmanuel Ndayambaje ◽  
Hongjun Lin ◽  
...  
Keyword(s):  
Chronic Exposure ◽  
Histopathological Changes

scholarly journals Assessing the potential effects of nevirapine in South African surface water on fish growth: A chronic exposure of Oreochromis mossambicus

2019 ◽  
Vol 115 (3/4) ◽  
Author(s):  
Marie Clémentine U. Nibamureke ◽  
Irene E.J. Barnhoorn ◽  
Gesina M. Wagenaar
Keyword(s):  
Growth Rate ◽  
Surface Water ◽  
South African ◽  
Chronic Exposure ◽  
Oreochromis Mossambicus ◽  
Fish Growth ◽  
Aquatic Environments ◽  
Life Stages ◽  
Mozambique Tilapia ◽  
Relevant Concentration

Aquatic environments around the world have become mixtures of different types of pollutants, including pharmaceuticals. The presence of pharmaceuticals in aquatic environments has raised concerns regarding the possibility of unintended effects on aquatic animals. South Africa is currently the largest consumer of HIV antiretroviral drugs (ARVs) worldwide. Nevirapine (NVP), a first-line ARV, has been associated with serious liver toxicity in humans and has been repeatedly detected in South African surface water. We investigated the potential effect of NVP on the growth of larvae and juveniles of the Mozambique tilapia (Oreochromis mossambicus) through a chronic laboratory exposure. Larval and early juvenile stages were exposed to the highest reported environmental relevant concentration of NVP in South African surface water (1.48 μg/L) for 60 days in a static renewal system. Body mass and total length measurements were recorded and analysed for individuals aged 1, 5, 30 and 60 days. In total, 455 fish were assessed. The growth parameters of larvae exposed to NVP were not statistically significantly different (p>0.05) from those of control larvae. However, the juveniles exposed to NVP showed a slightly lower mean growth rate between the 30th and 60th day compared with the control fish. These results suggest that the concentration of NVP in South African surface water has no significant detrimental effects on fish growth during the first 2 months of their life. Further studies to investigate the effects on all life stages of fish are needed as it is evident that the growth rate of exposed fish could be affected after this stage. Significance: This study was the first to investigate the effect of an antiretroviral drug in surface water on fish growth. Chronic exposure to the highest environmentally relevant concentration of nevirapine in South African waters did not affect the growth of early life stages of Mozambique tilapia. The levels of antiretrovirals in aquatic systems should be monitored closely as their consumption is likely to increase in the future.

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