604 Long Term Follow-Up of Implantable Loop Recorders: Prolonging Observation Period Increases Diagnostic Yield?

Purpose. To evaluate the efficacy and safety of femtolaser-assisted phacoemulsification in glaucomatous eyes in the long-term follow-up. Materials and methods. A retrospective analysis of the results of the surgical treatment of patients with combined cataract and glaucoma pathology was analyzed. The patients were divided into groups depending on the method of surgical intervention: 1) phacoemulsification with femtolaser support (26 eyes, 23 patients); 2) phacoemulsification (36 eyes, 30 patients); Results. Before surgery, there were no statistically significant differences in IOP and corneal hysteresis (СН) between groups 1 and 2. The mean values of IOP cc, IOP g and СН of group 1 before surgery were 22.7±6.1 mm Hg, 20.9±6.9 mm Hg, 8.5±1.6 mm Hg; 2 group – 22.9±8.7 mm Hg, 21.6±8.9 mm Hg, 8.9±1.6 mm Hg respectively. Average values of IOP cc, IOP g and CН 5 years after the surgical treatment in group 1 were 15.3±1.2 mm Hg, 14.4±3.4 mm Hg, 9.6±4.2 mm Hg; in group 2 – 18.0±4.2 mm Hg, 16.1±4.2 mm Hg, 8.8±2.2 mm Hg respectively. In both groups, stabilization of IOP and CH indices was noted, which remained throughout the entire observation period, which shows the normalization of the biomechanical properties of the corneoscleral membrane of the eye in the long-term postoperative period. Conclusion. Femtolaser accompaniment of phacoemulsification is an effective and safe method of cataract surgery for combined pathology. Key words: femtolaser, cataract, glaucoma, phacoemulsification.

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Coronary-coronary bypass grafting: artery or vein?

Asian Cardiovascular and Thoracic Annals ◽

10.1177/0218492320941689 ◽

2020 ◽

Vol 28 (6) ◽

pp. 316-321

Author(s):

Vladlen Bazylev ◽

Evgeny Rosseikin ◽

Dmitriy Tungusov ◽

Artur Mikulyak

Keyword(s):

Myocardial Revascularization ◽

Coronary Bypass ◽

Long Term Results ◽

Bypass Grafting ◽

Coronary Bypass Grafting ◽

Coronary Bypass Grafts ◽

Long Term Follow Up ◽

Observation Period

Background The method of coronary-coronary bypass grafting was described in 1987 but has not been widely used, and there are only a few studies that report good short-term and mid-term results as well as some individual cases of long-term follow-up. In our medical institution, we carried out an analysis of the long-term results of coronary-coronary bypass grafting, which are presented in this study. Methods This was a retrospective single-center study on 95 patients who underwent coronary-coronary bypass grafting as a supplement to the standard coronary bypass grafting procedure. All patients underwent angiographic assessment of the coronary bypass grafts during the long-term follow-up period. The observation period was up to 123 months. Angiographic assessment of 109 coronary-coronary grafts was carried out. Results Twelve (7.6%) arterial and 11 (19.3%) venous conduits were found to be occluded, and 8 (10.3%) arterial and 10 (31.3%) venous coronary-coronary grafts were occluded during the observation period. Conclusion Arterial coronary-coronary artery bypass grafting represents an alternative technique that allows complete myocardial revascularization.

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Long-term catheter angiography after aneurysm coil therapy: results of 209 patients and predictors of delayed recurrence and retreatment

Journal of Neurosurgery ◽

10.3171/2014.7.jns132433 ◽

2014 ◽

Vol 121 (5) ◽

pp. 1102-1106 ◽

Cited By ~ 31

Author(s):

Nohra Chalouhi ◽

Cory D. Bovenzi ◽

Vismay Thakkar ◽

Jeremy Dressler ◽

Pascal Jabbour ◽

...

Keyword(s):

Diagnostic Yield ◽

Cerebral Aneurysms ◽

Short Term ◽

Unruptured Intracranial Aneurysms ◽

Long Term Follow Up ◽

Major Shortcoming ◽

Male Sex ◽

A Minor

Object Aneurysm recurrence after coil therapy remains a major shortcoming in the endovascular management of cerebral aneurysms. The need for long-term imaging follow-up was recently investigated. This study assessed the diagnostic yield of long-term digital subtraction angiography (DSA) follow-up and determined predictors of delayed aneurysm recurrence and retreatment. Methods Inclusion criteria were as follows: 1) available short-term and long-term (> 36 months) follow-up DSA images, and 2) no or only minor aneurysm recurrence (not requiring further intervention, i.e., < 20%) documented on short-term follow-up DSA images. Results Of 209 patients included in the study, 88 (42%) presented with subarachnoid hemorrhage. On shortterm follow-up DSA images, 158 (75%) aneurysms showed no recurrence, and 51 (25%) showed minor recurrence (< 20%, not retreated). On long-term follow-up DSA images, 124 (59%) aneurysms showed no recurrence, and 85 (41%) aneurysms showed recurrence, of which 55 (26%) required retreatment. In multivariate analysis, the predictors of recurrence on long-term follow-up DSA images were as follows: 1) larger aneurysm size (p = 0.001), 2) male sex (p = 0.006), 3) conventional coil therapy (p = 0.05), 4) aneurysm location (p = 0.01), and 5) a minor recurrence on short-term follow-up DSA images (p = 0.007). Ruptured aneurysm status was not a predictive factor. The sensitivity of short-term follow-up DSA studies was only 40.0% for detecting delayed aneurysm recurrence and 45.5% for detecting delayed recurrence requiring further treatment. Conclusions The results of this study highlight the importance of long-term angiographic follow-up after coil therapy for ruptured and unruptured intracranial aneurysms. Predictors of delayed recurrence and retreatment include large aneurysms, recurrence on short-term follow-up DSA images (even minor), male sex, and conventional coil therapy.

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Long-term follow-up in patients with autonomous thyroid adenoma

Acta Endocrinologica ◽

10.1530/acta.0.1280051 ◽

1993 ◽

Vol 128 (1) ◽

pp. 51-55 ◽

Cited By ~ 64

Author(s):

D Sandrock ◽

T Olbricht ◽

D Emrich ◽

G Benker ◽

D Reinwein

Keyword(s):

Prognostic Value ◽

Definitive Treatment ◽

Thyroid Adenoma ◽

Trh Test ◽

Long Term Follow Up ◽

Autonomous Adenoma ◽

Observation Period ◽

Treatment Surgery

A group of 375 untreated euthyroid patients with solitary autonomous adenoma of the thyroid were studied in a long-term follow-up (observation period 52.8 (mean)/46 (median), range 3–204 months). During the period of observation, 133 (34.2%) of all initially untreated patients underwent treatment (surgery, radioiodine, antithyroid medication) because of hyperthyroidism, mechanical problems, or at the patient's request. Sixty-seven patients developed hyperthyroidism resulting in a mean incidence of 4.1% per year. The incidence of hyperthyroidism increased during follow-up (3% in the first seven years, 10% in the following years). Age, sex, nodule size, initial scintigraphic appearance and the TRH test were of no individual prognostic value in predicting hyperthyroidism. Eleven of 14 patients with untreated hyperthyroidism became euthyroid without treatment during the time of follow-up. After iodine excess (by history or elevated iodine levels in urine, N=45), 14 patients (31%) developed hyperthyroidism. In conclusion, we recommend a definitive treatment of autonomous adenoma at least in patients with advanced age, concomitant diseases and a higher probability of iodine exposure.

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Retrospective interview-based long-term follow-up study of cats diagnosed with idiopathic cystitis in 2003–2009

Journal of Feline Medicine and Surgery ◽

10.1177/1098612x21990302 ◽

2021 ◽

pp. 1098612X2199030

Author(s):

Anna V Eggertsdóttir ◽

Stine Blankvandsbråten ◽

Páll Gretarsson ◽

Anna E Olofsson ◽

Heidi S Lund

Keyword(s):

Clinical Signs ◽

Recurrence Rates ◽

Telephone Interviews ◽

Long Term Follow Up ◽

Tract Disease ◽

Long Term Prognosis ◽

Related Mortality ◽

Observation Period

Objectives The aim of this study was to register long-term recurrence rates and mortality rates in cats diagnosed with feline idiopathic cystitis (FIC), with an observation period until death or a minimum of 10 years. Methods Data regarding recurrence of signs of feline lower urinary tract disease (FLUTD) and FLUTD-related mortality in cats diagnosed with FIC between 2003 and 2009 were obtained through structured telephone interviews with the cat owners from December 2018 until February 2019. The interviews were based on a standardised questionnaire covering whether the cat was still alive or not, whether death/euthanasia were due to FLUTD and whether the cat had experienced recurrent episodes of clinical signs of FLUTD. If recurrences had occurred, exact numbers or estimates of 1–3, 4–6 or >6 recurrences were recorded. Results The owners of 50/105 FIC cats included in a previous study (48%) were available for inclusion in the present study. At the time of the interview, only 6/50 cats (12%) were still alive. The FLUTD-related mortality rate was 20% (n = 10/50). Twenty-three cats (46%) had no recurrences, three cats (6%) were euthanased shortly after diagnosis, nine cats (18%) had 1–3 recurrences, three cats (6%) had 4–6 recurrences and six cats (12%) had >6 recurrences. For the remaining six cats, the number of recurrences was uncertain. Conclusions and relevance The long-term prognosis for cats diagnosed with FIC may, based on the results from the present study, be regarded as fairly good, as approximately 70% of the cats either recovered without additional episodes, experienced only a few recurrences, are still alive after a minimum of 10 years since inclusion in the study, or were euthanased for reasons unrelated to FLUTD.

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Emergency Glomus-Sparing Carotid Endarterectomy According to A.N. Kazantsev

Russian Sklifosovsky Journal Emergency Medical Care ◽

10.23934/2223-9022-2020-9-4-494-503 ◽

2021 ◽

Vol 9 (4) ◽

pp. 494-503

Author(s):

A. N. Kazantsev ◽

K. P. Chernykh ◽

R. Yu. Lider ◽

N. E. Zarkua ◽

A. R. Shabayev ◽

...

Keyword(s):

Blood Pressure ◽

Ischemic Stroke ◽

Carotid Endarterectomy ◽

Internal Carotid ◽

Long Term Follow Up ◽

The Common ◽

Internal Carotid Arteries ◽

Observation Period

Aim of study. Analysis of the results of a new method of emergency glomus-sparing carotid endarterectomy (CEE) according to A.N. Kazantsev in the acute period of ischemic stroke.Material and methods. This cohort comparative prospective open-label study from January 2017 to April 2020 included 517 patients operated on for occlusive stenotic lesions of the internal carotid arteries (ICA) in the acute period of ischemic stroke (within 24 hours after the development of ischemic stroke). Depending on the implemented revascularization strategy, all patients were divided into three groups: group 1 — 214 patients (41.4%) — glomus-sparing CEE according to A.N. Kazantsev; 2nd group — 145 (28%) — classical CEE with plasty of the reconstruction zone with a patch; 3rd group — 158 (30.6%) — eversion CEE. The observation period was 35.2±9.6 months. Glomus-saving СE according to A.N. Kazantsev was carried out as follows. Arteriotomy with transition to the common carotid artery (CCA) was performed along the inner edge of the external carotid artery (ECA) adjacent to the carotid sinus, 2–3 cm above the ostium, depending on the spread of atherosclerotic plaque, the ICA was cut off at the site formed by the sections of the wall of the ECA and CCA. Then endarterectomy from the ICA was performed using the eversion technique. The next step was open endarterectomy from ECA and CCA. Then the ICA was implanted in the same position on the saved site.Results. In the hospital follow-up period, there were no significant intergroup differences in the number of complications. However, it should be noted that in the CEE group according to A.N. Kazantsev had no adverse cardiovascular events. In the long-term follow-up period, the smallest number of cardiovascular accidents was detected after CEE according to A.N. Kazantsev. However, intergroup differences were found only in the combined endpoint and the incidence of thrombosis, which were the highest in the 2nd and 3rd groups (p = 0.01). When analyzing the survival curves, it was revealed that the greatest number of cardiovascular accidents in the group of classical and eversion CEE occurred either during the hospital observation period or during the first months after surgery, and after CEE according to A.N. Kazantsev - in a year or more. When analyzing the graph of the dynamics of systolic blood pressure (BP), it was revealed that after glomus-sparing CEE according to A.N. Kazantsev, stable numbers are maintained while receiving preoperative antihypertensive therapy and do not rise above 140 mm Hg. In turn, after classical and eversion CEE, critical hypertension persists in the first three days, which is difficult to treat. In the future, blood pressure figures are unstable and fluctuate in the range from 140 to 160 mm Hg. All cases of myocardial infarction and ischemic stroke were recorded against the background of critical numbers of systolic blood pressure, reaching 180-200 mm Hg.Conclusion. The presented glomus-sparing carotid endarterectomy according to A.N. Kazantsev meets the modern standards of carotid surgery, combined with the minimum permissible risks of developing adverse cardiovascular events, both in hospital and in the long-term follow-up. The confident effect of the developed revascularization is based on the precise removal of plaque from the common, external and internal carotid arteries, as well as maintaining the stability of hemodynamic parameters.

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THYROID DISEASE IN THE LATE OBSERVATION PERIOD UPON CHEMO- AND RADIOTHERAPY IN CHILDREN-SURVIVORS OF ACUTE LYMPHOBLASTIC LEUKEMIA

Проблеми радіаційної медицини та радіобіології = Problems of Radiation Medicine and Radiobiology ◽

10.33145/2304-8336-2021-26-309-318 ◽

2021 ◽

Vol 26 ◽

pp. 309-318

Author(s):

V. Bebeshko ◽

◽

K. Bruslova ◽

L. Lyashenko ◽

N. Tsvіetkova ◽

...

Keyword(s):

Thyroid Cancer ◽

Acute Lymphoblastic Leukemia ◽

Thyroid Disease ◽

Lymphoblastic Leukemia ◽

Endocrine Diseases ◽

Long Term Follow Up ◽

Prepubertal Age ◽

Observation Period

Objective: to assess the thyroid disease in the late observation period in children who had received chemo- and radiotherapy for the acute lymphoblastic leukemia (ALL) taking into account gender, age period and disease subtype. Materials and methods. The incidence and nature of thyroid disease (hypothyroidism, thyroiditis, and thyroid cancer) were studied in children-survivors of acute lymphoblastic leukemia (ALL) being in remission from 6 to 25 years. The distribution of patients by leukemia subtypes was as follows: «common» – 67.4 %, pre-B – 23.9 %, pro-B and T-cell – 4.3 %. Children had been receiving chemo- and radiotherapy according to the protocol. Regarding the age of patients at the time of ALL diagnosis the prepubertal, pubertal and postpubertal periods were taken into account. The endocrine diseases in family history, body weight at birth, serum content of free thyroxine, pituitary thyroidstimulating hormone, cortisol, iron, ferritin and thyroperoxidase antibodies were evaluated and assayed. Results. Thyroid disease in children was emerging in the first 2–3 years after the ALL treatment with an incidence of 22.8 % (hypothyroidism – 14.1 %, autoimmune thyroiditis – 7.6 %, papillary cancer – 1.1 %). Seven children in this group had received radiotherapy (12-18 Gy doses) on the central nervous system (CNS). No correlation was found between the radiation exposure event itself, radiation dose to the CNS and thyroid disease in the long-term follow-up period. Thyroid cancer had developed in a child 11 years upon chemo- and radiotherapy. Hypothyroidism was more often diagnosed in the patients of prepubertal age (rs = 0.49). There were endocrine diseases in the family history in about a half of children, being significantly higher than in the general sample (р < 0.05). The body weight at birth of a child who had later developed hypothyroidism was less than in children having got thyroiditis (rs = 0.57). Conclusions. Disorders in endocrine regulation and of thyroid in particular can affect the prognosis of blood cancer course in the long-term follow-up in children, especially in prepubertal age, which requires systematic supervision by hematologist and endocrinologist. Key words: children, acute lymphoblastic leukemia, chemotherapy, radiotherapy, thyroid cancer, hypothyroidism, thyroiditis, late period.

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Cystatin C as a predictor of acute renal damage after radical surgical treatment in patients with muscle-invasive bladder cancer

Research n Practical Medicine Journal ◽

10.17709/2410-1893-2021-8-2-7 ◽

2021 ◽

Vol 8 (2) ◽

pp. 75-82

Author(s):

A. I. Tarasenko ◽

V. N. Pavlov ◽

I. R. Kabirov ◽

A. V. Alekseev ◽

M. F. Urmantsev

Keyword(s):

Cystatin C ◽

Renal Damage ◽

Prognostic Significance ◽

Muscle Invasive Bladder Cancer ◽

Long Term Follow Up ◽

Muscle Invasive ◽

Urinary Cystatin C ◽

Observation Period

Purpose of the study. To assess the clinical and prognostic significance of serum and urinary cystatin C (uCys-C and sCys-C) in patients undergoing radical cystectomy (RC) in relation to AKI.Patients and methods. In this prospective study, uCys-C and sCys-C levels were measured during the first week after undergoing RC in a heterogeneous group of patients undergoing RC (n=186), mean age 59.5±11.4 years. The observation period of the patients was 6 months. The diagnosis of AKI that developed within the first week after surgery was based on the KDIGO criteria.Results. Of the 186 examined patients, 43 developed AKI according to generally accepted criteria. During the follow-up period, no patient required renal replacement therapy. AKI patients had a longer hospital stay (22.4±22.9 versus 13.0±4.1). The sCys-C levels were significantly associated with the occurrence of AKI and CKD in the long-term postoperative period and had an area under the ROC curve of 0.76 and 0.81, respectively, for predicting severe outcomes. At an optimal cut-off value of 161.17 ng/ml, sCys-C showed a sensitivity of 65 % and a specificity of 58 % for predicting AKI. The greatest increase in the concentration of sCys-C was detected 6-12 hours after surgery, followed by a decrease in the long-term follow-up.Conclusion. Peak sCys-C levels are associated with AKI and independently predict the development of AKI in patients after RC and the onset of CKD within 6 months.

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Prevalence of Antiphospholipid Antibodies Negativisation in Patients with Antiphospholipid Syndrome: A Long-Term Follow-Up Multicentre Study

Thrombosis and Haemostasis ◽

10.1055/s-0039-1696687 ◽

2019 ◽

Vol 119 (12) ◽

pp. 1920-1926 ◽

Cited By ~ 1

Author(s):

Massimo Radin ◽

Karen Schreiber ◽

Savino Sciascia ◽

Dario Roccatello ◽

Irene Cecchi ◽

...

Keyword(s):

Antiphospholipid Syndrome ◽

Antiphospholipid Antibodies ◽

Thrombotic Event ◽

Clinical Manifestations ◽

Inclusion Criteria ◽

Pregnancy Morbidity ◽

Long Term Follow Up ◽

Observation Period

Abstract Objective This article aims to analyse the rate of antiphospholipid antibodies (aPL) negativisation in patients with antiphospholipid syndrome (APS), and to evaluate potential new clinical manifestations after negativisation and/or aPL fluctuations in a long-term follow-up. Methods Inclusion criteria are (1) any patients with an APS diagnosis according to the current Sydney criteria and (2) patients in whom aPL negativisation occurred. aPL negativisation was defined as repeated aPL measurements on at least two consecutive occasions at least 12 weeks apart, with a follow-up of at least 1 year since aPL first turned negative. Results Out of 259 APS patients, a total of 23 patients (8.9%) met the inclusion criteria for persistent aPL negativisation. Patients were followed-up for 14.4 ± 8.1 years, experienced aPL negativisation after a mean of 5.3 ± 3.5 years and were followed-up after experiencing the aPL negativisation for a mean of 7.6 ± 5.8 years. Seventeen patients (73.9%) presented with thrombotic APS, 2 with pregnancy morbidity (8.7%) and 4 (17.4%) with both. Most of the patients (18; 78.3%) had a single aPL positivity, 5 (21.7%) double, while no triple aPL positivity was observed. At the time of data collection, after aPL negativisation, anticoagulation was stopped in 8 patients with previous thrombotic venous event (8/21, 38%) according to the treating physicians' judgements. None of the patients experienced any recurrent thrombotic event during the follow-up period after their aPL negativisation. Conclusion In our patient cohort consisting of 259 patients with definitive APS, we observed over a mean observation period of > 5 years, that aPL negativisation occurred in approximately 9% of patients. Negativisation occurred most often in patients who were previously found to be positive for only one aPL.

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Basilar Migraine with Electroencephalographic Findings of Occipital Spike-Wave Complexes: A Long-Term Study in Seven Children

Cephalalgia ◽

10.1046/j.1468-2982.1993.1303192.x ◽

1993 ◽

Vol 13 (3) ◽

pp. 192-196 ◽

Cited By ~ 24

Author(s):

Filippo De Romanis ◽

M Gabriella Buzzi ◽

Salvatore Assenza ◽

Livia Brusa ◽

Rosanna Cerbo

Keyword(s):

Term Study ◽

Prodromal Symptoms ◽

Long Term Study ◽

Long Term Follow Up ◽

Symptoms And Signs ◽

Posterior Cerebral Circulation ◽

Observation Period ◽

Spike Wave

Basilar migraine is characterized by headache preceded by prodromal symptoms and signs of posterior cerebral circulation dysfunction. Few studies have focused on EEG findings in this condition or on the prognosis of occipital spike-wave complexes observed in either migraine or epilepsy. We now report a long-term follow-up (8–16 years) in seven children affected by basilar migraine who had EEG findings of occipital spike-wave complexes. Basilar migraine resolved and the EEG became normal in all subjects during the observation period, as did migraine with aura and seizures which developed in some of the patients after basilar migraine attacks ceased.

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