In vivo and in vitro application of thin film interferometry to assess contact lens wettability

2018 ◽  
Vol 41 ◽  
pp. S9
Author(s):  
Raied Fagehi ◽  
Ian Pearce ◽  
Katherine Oliver ◽  
Alan Tomlinson
Keyword(s):  
Thin Film ◽  
Contact Lens

scholarly journals In vitro and Short-term in vivo Characteristics of a Kel-F Thin Film Modified Glucose Sensor

2003 ◽  
Vol 19 (11) ◽  
pp. 1481-1486 ◽  
Author(s):  
Sun Kil KANG ◽  
Ran-A JEONG ◽  
Sejin PARK ◽  
Taek Dong CHUNG ◽  
Sunmin PARK ◽  
...  
Keyword(s):  
Thin Film ◽  
Glucose Sensor ◽  
Short Term

In vitro and in vivo testing of a novel, hyperelastic thin film nitinol flow diversion stent

2011 ◽  
Vol 100B (3) ◽  
pp. 718-725 ◽  
Author(s):  
C. P. Kealey ◽  
Y. J. Chun ◽  
F. E. Viñuela ◽  
K. P. Mohanchandra ◽  
G. P. Carman ◽  
...  
Keyword(s):  
Thin Film ◽  
Flow Diversion ◽  
In Vivo Testing

scholarly journals Incorporation of Silicon Carbide and Diamond-Like Carbon as Adhesion Promoters Improves In Vitro and In Vivo Stability of Thin-Film Glassy Carbon Electrocorticography Arrays

2017 ◽  
Vol 2 (1) ◽  
pp. 1700081 ◽  
Author(s):  
Maria Vomero ◽  
Elisa Castagnola ◽  
Juan S. Ordonez ◽  
Stefano Carli ◽  
Elena Zucchini ◽  
...  
Keyword(s):  
Thin Film ◽  
Silicon Carbide ◽  
Glassy Carbon ◽  
Diamond Like Carbon ◽  
Adhesion Promoters

scholarly journals In Vitro and In Vivo Performance of Dry Powder Inhalation Formulations: Comparison of Particles Prepared by Thin Film Freezing and Micronization

2014 ◽  
Vol 15 (4) ◽  
pp. 981-993 ◽  
Author(s):  
Yi-Bo Wang ◽  
Alan B. Watts ◽  
Jay I. Peters ◽  
Sha Liu ◽  
Ayesha Batra ◽  
...  
Keyword(s):  
Thin Film ◽  
Dry Powder Inhalation ◽  
Dry Powder ◽  
Thin Film Freezing

scholarly journals FORMULATION AND EVALUATION OF CURCUMIN LOADED LIPOSOME AND ITS BIO-ENHANCEMENT

2019 ◽  
Vol 9 (4-A) ◽  
pp. 425-437
Author(s):  
Khushboo Verma ◽  
Jhakeshwar Prasad ◽  
Suman Saha ◽  
Surabhi Sahu
Keyword(s):  
Thin Film ◽  
Particle Size ◽  
Drug Release ◽  
Zeta Potential ◽  
High Performance ◽  
Encapsulation Efficiency ◽  
Mean Particle Size ◽  
Liposome Formulation

The aim of this work was to develop and evaluate curcumin loaded liposome and its bio- enhancement. Curcumin was selected as a natural drug for liposome formulation. Curcumin show variety of biological activity but it also shows poor bioavailability due to low aqueous solubility (1 µg/ml), poor absorption and rapid metabolism so that piperine was selected as bio enhancer to improve curcumin bioavailability. Soy lecithin and cholesterol were used to prepared curcumin and curcumin-piperine loaded liposome at different ratio by thin film hydration method because of easy to perform, and high encapsulation rates of lipid. The all liposome formulations (F1-F5) were evaluated by mean particle size, polydispersity index, zeta potential, encapsulation efficiency and drug release. Bioavailability was also determined on rat. Blood samples were collected at specific intervals, and plasma was separated by ultracentrifugation. Plasma was analyzed by high-performance liquid chromatography at 425 nm taking acetonitrile: water (75:25 v/v) acidified with 2% acetic acid as a mobile phase at a flow rate of 0.5 ml/min using C18 column. The mean particle size was found in the range between 800-1100 that indicate liposome are large unilamellar vesical types. By zeta potential study its conform that the all formulation was stable. The encapsulation efficiency of all liposome formulation are varied between 59-67%. In vitro drug release was analyse in 7.4 pH phosphate buffer, the maximum %CDR observed at the 12 hrs., and formulation are follow sustained release thus they reduce metabolism, good absorption rate which improve bioavailability of drug. From in-vivo study, it is clear that curcumin-piperine liposomal formulation, increases Cmax, area under the curve, and mean residence time significantly as compared to pure curcumin and pure curcumin liposome. Keywords: liposome; Curcumin; Piperine, Thin film hydration method; Bioavailability

scholarly journals The Bio-Tribological Effect of Poly-Gamma-Glutamic Acid in the Lysozyme-Ionic Contact Lens System

Polymers ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 156
Author(s):  
Chen-Ying Su ◽  
Lung-Kun Yeh ◽  
Chi-Chun Lai ◽  
Mihaela Dubuisson ◽  
Yi-Fei Tsao ◽  
...  
Keyword(s):  
Friction Coefficient ◽  
Glutamic Acid ◽  
Contact Lens ◽  
Contact Lenses ◽  
Lens System ◽  
Friction Testing ◽  
Lubricating Property ◽  
Velocity Variations

Feeling comfortable is an important issue for contact lens wearers as contact lenses are worn for an extensive period of time. It has been shown that the in vitro friction coefficient of contact lenses is correlated to the degree of in vivo comfort, thus many studies focus on establishing friction testing methods for investigating the friction coefficient of contact lenses or contact lens care solution. We have previously demonstrated the lubricating property of poly-gamma-glutamic acid (γ-PGA)-containing care solution, and it could reduce the high friction coefficient caused by lysozyme. However, the mechanism of how γ-PGA-containing care solution reduces the lysozyme-induced friction coefficient of contact lenses is unclear. We investigated the bio-tribological effect of γ-PGA on ionic contact lenses in the presence of lysozyme by testing load and velocity variations. The ability to remove lysozyme deposition by γ-PGA and viscosity analysis of γ-PGA-containing care solutions were also investigated to understand the potential mechanism. Our results showed that the friction coefficient of γ-PGA-containing care solution with lysozyme was the lowest in both load and velocity variations, and γ-PGA functions distinctly in the lysozyme-ionic contact lens system. We proposed a model of how γ-PGA could reduce the friction coefficient in these two conditions.

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