scholarly journals Influence and efficiency of an anti-diabetic drug Metformin hydrochloride as an uncoupler: Reducing sludge production

2021 ◽  
pp. 100203
Author(s):  
Jun Li ◽  
Salma Tabassum
Keyword(s):  
Metformin Hydrochloride ◽  
Sludge Production

Controlled Release of Metformin Hydrochloride I. In vitro Release from Physical Mixture Containing Xanthan Gum as Hydrophilic Rate Retarding Polymer

1970 ◽  
Vol 4 (1) ◽  
Author(s):  
Mashkura Ashrafi ◽  
Jakir Ahmed Chowdhury ◽  
Md Selim Reza
Keyword(s):  
Controlled Release ◽  
Xanthan Gum ◽  
In Vitro Release ◽  
Correlation Coefficients ◽  
High Ratio ◽  
Water Soluble ◽  
Metformin Hydrochloride ◽  
Model Drug ◽  
Very High

Capsules of different formulations were prepared by using a hydrophilic polymer, xanthan gum and a filler Ludipress. Metformin hydrochloride, which is an anti-diabetic agent, was used as a model drug here with the aim to formulate sustained release capsules. In the first 6 formulations, metformin hydrochloride and xanthan gum were used in different ratio. Later, Ludipress was added to the formulations in a percentage of 8% to 41%. The total procedure was carried out by physical mixing of the ingredients and filling in capsule shells of size ‘1’. As metformin hydrochloride is a highly water soluble drug, the dissolution test was done in 250 ml distilled water in a thermal shaker (Memmert) with a shaking speed of 50 rpm at 370C &plusmn 0.50C for 6 hours. After the dissolution, the data were treated with different kinetic models. The results found from the graphs and data show that the formulations follow the Higuchian release pattern as they showed correlation coefficients greater than 0.99 and the sustaining effect of the formulations was very high when the xanthan gum was used in a very high ratio with the drug. It was also investigated that the Ludipress extended the sustaining effect of the formulation to some extent. But after a certain period, Ludipress did not show any significant effect as the pores made by the xanthan gum network were already blocked. It is found here that when the metformin hydrochloride and the xanthan gum ratio was 1:1, showed a high percentage of drug release, i.e. 91.80% of drug was released after 6 hours. But With a xanthan gum and metformin hydrochloride ratio of 6:1, a very slow release of the drug was obtained. Only 66.68% of the drug was released after 6 hours. The percent loading in this case was 14%. Again, when Ludipress was used in high ratio, it was found to retard the release rate more prominently. Key words: Metformin Hydrochloride, Xanthan Gum, Controlled release capsule Dhaka Univ. J. Pharm. Sci. Vol.4(1) 2005 The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website

A Batch Activated Sludge Study of Pineapple Wastewater Using a Bioaugmentation Process

1991 ◽  
Vol 24 (5) ◽  
pp. 233-240 ◽  
Author(s):  
Nik Fuaad Nik Abllah ◽  
Aik Heng Lee
Keyword(s):  
Activated Sludge ◽  
Removal Efficiency ◽  
Treatment Plant ◽  
Domestic Wastewater ◽  
Ammonia Nitrogen ◽  
Batch Reactors ◽  
Organic Loading ◽  
Suitable Alternative ◽  
Organic Removal ◽  
Sludge Production

A laboratory study was conducted to determine the feasibility of batch activated sludge reactor for treating pineapple wastewater and to examine the effects of bioaugmentation on treatment performance. The experimental set-up consists of eleven batch reactors. Activated sludge obtained from a wastewater treatment plant treating domestic wastewater was used as seed for the reactors. Synthetic pineapple wastewater was used as feed for the reactors. The eleven reactors were arranged to evaluate the total organic removal, nitrification, and sludge production by bioaugmentation process. Three major factors considered were influent organic loading, ammonia-nitrogen, and dosage of bacterial-culture-product addition. Removal of TOG (total organic carbon), sludge production in terms of SS(suspended solids), and ammonia-nitrogen removal variation are used as evaluation parameters. The TOC removal efficiency after the end of a 48 hour reactor run, for influent TOC of 350.14 to 363.30 mg/l, and 145.92 to 169.66 mg/l, was 94.41 to 95.89%, and 93.72 to 94.73% respectively. Higher organic removal was observed in the bioaugmented reactors with higher organic loading. The better organic removal efficiency in the bioaugmented reactors was probably due to activities of bacteria added. The test results also indicated that sludge yield was enhanced by the bacteria additive and high bacteria dosage produced less sludge. Bioaugmentation was observed to be a suitable alternative for enhancing the biological treatment of pineapple wastewater.

Minimization of activated sludge production by chemically stimulated energy spilling

2000 ◽  
Vol 42 (12) ◽  
pp. 189-200 ◽  
Author(s):  
G.-H. Chen ◽  
H.-K. Mo ◽  
S. Saby ◽  
W.-k. Yip ◽  
Y. Liu
Keyword(s):  
Activated Sludge ◽  
Growth Yield ◽  
Dry Weight ◽  
Staining Technique ◽  
Microbial Culture ◽  
Dapi Staining ◽  
E Coli ◽  
Energy Spilling ◽  
Activated Sludge Processes ◽  
Sludge Production

Minimization of excess sludge production in activated sludge processes has been pursued around the world in order to meet stringent environmental regulations on sludge treatment and disposal. To achieve this goal, physical, chemical, and biological approaches have been proposed. In this paper, a chemical compound, 3,3′,4′,5-tetrachlorosalicylanilide (TCS) was tested for enhancing microbial energy spilling of the sludgeso as to minimize its growth. In order to examine this, an exploratory study was conducted using both batch and continuous activated sludge cultures. Batch experiments with these two cultures were carried out at different initial concentrations of TCS. It has been confirmed that an addition of TCS is effective in reducing the production of both the sludge cultures, particularly the continuous culture where the observed growth yield was reduced by around 70%, when the initial TCS concentration was 0.8 ppm. Meanwhile, the substrate removal activity of this culture was found not to be affected at this TCS concentration. To further evaluate the TCS effect, a pure microbial culture of E. coli was employed. Batch experiment results with this culture implied that TCS might be able to reduce the cell density of E. coli drastically when an initial TCS concentration was greater than 0.12 ppm. It was also found that TCS was not toxic to this type of bacteria. Microscopic examinations with a 4′, 6-diamidino-2-phenylindole (DAPI) staining technique revealed that TCS neither affected the cell division nor altered the cell size of E. coli. However, both the cell ATP content and the cell dry weight were reduced significantly with the addition of TCS.

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