Computer simulation based on in vivo kinematics of a replaced hip during chair-rising for elucidating target cup positioning with a safety range of hip rotation

Congenital heart surgeons’ training is complex and challenging. The learning curve is long and the increasing complexity of pathologies is demanding. In order to develop adequate surgical-skill competencies, “in vivo” and simulation-based practicing are paramount. Simulation can be performed either on a computer screen or animal hearts and prosthetic models. In this article, we illustrate a porcine Wet Lab simulation for the Nikaidoh operation to point out its potential advantage to learn complex congenital surgery procedures.

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Experimental and theoretical explorations of nanocarriers’ multistep delivery performance for rational design and anticancer prediction

Science Advances ◽

10.1126/sciadv.aba2458 ◽

2021 ◽

Vol 7 (6) ◽

pp. eaba2458

Author(s):

Weier Bao ◽

Falin Tian ◽

Chengliang Lyu ◽

Bin Liu ◽

Bin Li ◽

...

Keyword(s):

Physical Properties ◽

Rational Design ◽

Theoretical Models ◽

Cell Uptake ◽

Anticancer Efficacy ◽

Delivery Performance ◽

Simulation Based ◽

Multistep Process

The poor understanding of the complex multistep process taken by nanocarriers during the delivery process limits the delivery efficiencies and further hinders the translation of these systems into medicine. Here, we describe a series of six self-assembled nanocarrier types with systematically altered physical properties including size, shape, and rigidity, as well as both in vitro and in vivo analyses of their performance in blood circulation, tumor penetration, cancer cell uptake, and anticancer efficacy. We also developed both data and simulation-based models for understanding the influence of physical properties, both individually and considered together, on each delivery step and overall delivery process. Thus, beyond finding that nanocarriers that are simultaneously endowed with tubular shape, short length, and low rigidity outperformed the other types, we now have a suit of theoretical models that can predict how nanocarrier properties will individually and collectively perform in the multistep delivery of anticancer therapies.

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In Vivo Kinematics of Functional Ankle Instability Patients and Lateral Ankle Sprain Copers During Stair Descent

Journal of Orthopaedic Research® ◽

10.1002/jor.24303 ◽

2019 ◽

Vol 37 (8) ◽

pp. 1860-1867 ◽

Cited By ~ 2

Author(s):

Shengxuan Cao ◽

Chen Wang ◽

Xin Ma ◽

Xu Wang ◽

Jiazhang Huang ◽

...

Keyword(s):

Ankle Sprain ◽

Ankle Instability ◽

Functional Ankle Instability ◽

Lateral Ankle Sprain ◽

Lateral Ankle ◽

In Vivo Kinematics ◽

Stair Descent

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Nursing Students’ Experiences with Computer Simulation-Based Communication Education

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18063108 ◽

2021 ◽

Vol 18 (6) ◽

pp. 3108

Author(s):

Ujin Lee ◽

Heeseung Choi ◽

Yeseul Jeon

Keyword(s):

Computer Simulation ◽

Nursing Education ◽

Nursing Students ◽

Communication Patterns ◽

Mixed Method Research ◽

Communication Education ◽

Therapeutic Communication ◽

Clinical Practicum ◽

Content Analysis Method ◽

Simulation Based

Simulation-based communication education has improved nursing students’ communication knowledge and skills. However, communication patterns that students commonly exhibit in simulated situations and students’ responses to specific clinical situations have not been systematically examined. The specific aims of the present study were (1) to identify non-therapeutic communication patterns that nursing students exhibit in simulated situations in the computer simulation-based education (ComEd) program, and (2) explore students’ responses to challenging clinical situations. This study used a mixed-method research design and a convenience sampling method to recruit participants. Frequency analysis and a conventional content analysis method were used to analyze answers provided by participants. A total of 66 students from four Korean nursing schools participated in the study. “False reassurance” was found to be the most common non-therapeutic communication pattern used by nursing students. Nursing students had difficulty in clinical situations such as reporting a patient’s condition to a doctor, communicating with a patient and perform basic nursing skills at the same time, and managing conflicts between patients. Technology-based communication simulation programs, which reflect various clinical situations, are considered a new alternative that can supplement the limitations of clinical practicum and improve the quality of nursing education.

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Effects of Computer Simulation Training on In Vivo Discrete Trial Teaching

Journal of Autism and Developmental Disorders ◽

10.1007/s10803-012-1593-x ◽

2012 ◽

Vol 43 (3) ◽

pp. 569-578 ◽

Cited By ~ 12

Author(s):

Sigmund Eldevik ◽

Iwona Ondire ◽

J. Carl Hughes ◽

Corinna F. Grindle ◽

Tom Randell ◽

...

Keyword(s):

Computer Simulation ◽

Simulation Training ◽

Discrete Trial Teaching ◽

Discrete Trial

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Lateral Extra-articular Tenodesis Contributes Little to Change In Vivo Kinematics After Anterior Cruciate Ligament Reconstruction: A Randomized Controlled Trial

The American Journal of Sports Medicine ◽

10.1177/03635465211003298 ◽

2021 ◽

pp. 036354652110032

Author(s):

Daisuke Chiba ◽

Tom Gale ◽

Kyohei Nishida ◽

Felipe Suntaxi ◽

Bryson P. Lesniak ◽

...

Keyword(s):

Anterior Cruciate Ligament ◽

Cruciate Ligament ◽

P Value ◽

In Vivo Kinematics ◽

Acl Deficiency ◽

Downhill Running ◽

Value Range ◽

Foot Strike ◽

Anterior Cruciate

Background: Lateral extra-articular tenodesis (LET) in combination with anterior cruciate ligament (ACL) reconstruction (ACLR) has been proposed to improve residual rotatory knee instability in patients having ACL deficiency. Purpose/Hypothesis: The purpose was to compare the effects of isolated ACLR (iACLR) versus LET in combination with ACLR (ACLR+LET) on in vivo kinematics during downhill running. It was hypothesized that ACLR+LET would reduce the internal rotation of the reconstructed knee in comparison with iACLR. Study Design: Controlled laboratory study. Methods: A total of 18 patients with ACL deficiency were included. All participants were randomly assigned to receive ACLR+ LET or iACLR during surgery. Six months and 12 months after surgery, knee joint motion during downhill running was measured using dynamic biplane radiography and a validated registration process that matched patient-specific 3-dimensional bone models to synchronized biplane radiographs. Anterior tibial translation (ATT; positive value means “anterior translation”) and tibial rotation (TR) relative to the femur were calculated for both knees. The side-to-side differences (SSDs) in kinematics were also calculated (operated knee–contralateral healthy knee). The SSD value was compared between ACLR+LET and iACLR groups using a Mann-Whitney U test. Results: At 6 months after surgery, the SSD of ATT in patients who had undergone ACLR+LET (–1.9 ± 2.0 mm) was significantly greater than that in patients who had undergone iACLR (0.9 ± 2.3 mm) at 0% of the gait cycle (foot strike) ( P = .031). There was no difference in ATT 12 months after surgery. Regarding TR, there were no differences between ACLR+LET and iACLR at either 6 months ( P value range, .161-.605) or 12 months ( P value range, .083-.279) after surgery. Conclusion: LET in combination with ACLR significantly reduced ATT at the instant of foot strike during downhill running at 6 months after surgery. However, this effect was not significant at 12 months after surgery. The addition of LET to ACLR had no effect on TR at both 6 and 12 months after surgery. Clinical Relevance: LET in combination with ACLR may stabilize sagittal knee motion during downhill running in the early postoperation phase, but according to this study, it has no effect on 12-month in vivo kinematics. Registration: NCT02913404 ( ClinicalTrials.gov identifier)

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From behavioural simulation to computer models: how simulation can be used to improve healthcare management and policy

BMJ Simulation and Technology Enhanced Learning ◽

10.1136/bmjstel-2018-000377 ◽

2018 ◽

Vol 6 (2) ◽

pp. 95-102 ◽

Cited By ~ 4

Author(s):

Guillaume Lamé ◽

Rebecca K Simmons

Keyword(s):

Computer Simulations ◽

Policy Making ◽

Simulation Method ◽

Healthcare Management ◽

Policies And Procedures ◽

Simulation Based ◽

Behavioural Simulation ◽

Human Participants ◽

New Policies

Simulation is a technique that evokes or replicates substantial aspects of the real world, in order to experiment with a simplified imitation of an operations system, for the purpose of better understanding and/or improving that system. Simulation provides a safe environment for investigating individual and organisational behaviour and a risk-free testbed for new policies and procedures. Therefore, it can complement or replace direct field observations and trial-and-error approaches, which can be time consuming, costly and difficult to carry out. However, simulation has low adoption as a research and improvement tool in healthcare management and policy-making. The literature on simulation in these fields is dispersed across different disciplinary traditions and typically focuses on a single simulation method. In this article, we examine how simulation can be used to investigate, understand and improve management and policy-making in healthcare organisations. We develop the rationale for using simulation and provide an integrative overview of existing approaches, using examples of in vivo behavioural simulations involving live participants, pure in silico computer simulations and intermediate approaches (virtual simulation) where human participants interact with computer simulations of health organisations. We also discuss the combination of these approaches to organisational simulation and the evaluation of simulation-based interventions.

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