A randomized, double-blind clinical study to assess the antimicrobial effects of a cetylpyridinium chloride mouth rinse on dental plaque bacteria

2009 ◽  
Vol 31 (11) ◽  
pp. 2540-2548 ◽  
Author(s):  
Deyu Hu ◽  
Xue Li ◽  
Prem K. Sreenivasan ◽  
William DeVizio
Keyword(s):  
Clinical Study ◽  
Dental Plaque ◽  
Cetylpyridinium Chloride ◽  
Mouth Rinse ◽  
Double Blind ◽  
Antimicrobial Effects

Hop Bract Polyphenols Reduced Three-day Dental Plaque Regrowth

2007 ◽  
Vol 86 (9) ◽  
pp. 848-851 ◽  
Author(s):  
K. Shinada ◽  
M. Tagashira ◽  
H. Watanabe ◽  
P. Sopapornamorn ◽  
A. Kanayama ◽  
...  
Keyword(s):  
Clinical Study ◽  
Oral Hygiene ◽  
Dental Plaque ◽  
Mutans Streptococci ◽  
Healthy Male ◽  
Inhibitory Effects ◽  
Performance Score ◽  
Double Blind ◽  
The Mean

Previous research has shown the inhibitory effects of hop bract polyphenols (HBP) on cariogenic streptococci in vitro, but their effects in humans have not been investigated. This double-blind, crossover clinical study tested the hypothesis that HBP delivered in a mouthrinse suppresses plaque regrowth in humans. Twenty-nine healthy male volunteers had all plaque removed, and refrained from all oral hygiene for 3 days, except for rinsing with a mouthrinse containing 0.1% HBP or a placebo. The results showed that the mean amount of plaque assessed by the Patient Hygiene Performance score after the volunteers used the HBP mouthrinse was significantly less than that after they used the placebo (p < 0.001). The number of mutans streptococci in the plaque samples after volunteers used the HBP mouthrinse was significantly lower than that after they used the placebo (p < 0.05). These findings suggested that HBP, delivered in a mouthrinse, successfully reduced dental plaque regrowth in humans.

scholarly journals EFFICACY OF MOUTH RINSE FORMULATION BASED ON CETYLPYRIDINIUM CHLORIDE 0.1% IN THE CONTROL OF DENTAL CALCULUS BUILDUP

2017 ◽  
Vol 9 ◽  
pp. 176 ◽  
Author(s):  
Diah Ayu Maharani ◽  
Alia Ramadhani ◽  
Melissa Adiatman ◽  
Yuniardini Septorini Wimardhani ◽  
Linda Kusdhany ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Cetylpyridinium Chloride ◽  
Positive Control ◽  
Negative Control ◽  
Mouth Rinse ◽  
Dental Calculus ◽  
Double Blind ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Objective: This study aimed at comparing the antiplaque, anticalculus, and antigingivitis potentials of a mouth rinse containing essential oil, alcohol,zinc, and fluoride with a mouth rinse containing cetylpyridinium chloride (CPC) 0.1% over 1-, 2-, and 3-month periods.Methods: This study was a double-blind, parallel randomized clinical trial with a 3-day run-in phase. Respondents were asked to gargle twice dailywith 15 ml of mouth rinse for 30 seconds after brushing teeth. Respondents were 80 females with a mean age of 21 years, and a single dental examinerwas employed throughout the study to decrease the variance. Prophylaxis was performed for all respondents before the intervention. Three mouthrinses were tested: Group 1 with the mouth rinse containing CPC 0.1%, Group 2 as the negative control, and Group 3 as the positive control with amouth rinse containing alcohol. Evaluations were conducted by plaque index, gingival index, calculus index, and CariScreen examinations.Results: The clinical trial showed that the mouth rinse with alcohol and the mouth rinse containing CPC 0.1% were effective in inhibiting bacterialbuildup (antiplaque) and have anticalculus properties, but with no statistically significant antigingivitis effect.Conclusion: It was found that the mouth rinse containing alcohol has similar effectiveness with CPC 0.1% mouth rinse, but side effects, such as aburning sensation, were reported in the alcohol-containing mouth rinse.

scholarly journals A randomized, double‑blind clinical study to assess the antiplaque and antigingivitis efficacy of Aloe vera mouth rinse

2012 ◽  
Vol 16 (4) ◽  
pp. 543 ◽  
Author(s):  
Avula Jayakumar ◽  
Anumala Naveen ◽  
Kalakonda Butchibabu ◽  
PathakotaKrishnanjaneya Reddy ◽  
Tupili Muralikrishna ◽  
...  
Keyword(s):  
Clinical Study ◽  
Aloe Vera ◽  
Mouth Rinse ◽  
Double Blind

scholarly journals A study of anti-plaque efficacy and taste perception of Calendula officinalis mouth rinse

2020 ◽  
Vol 32 (3) ◽  
pp. 190
Author(s):  
Erry Mochamad Arief ◽  
Zaridah Zainal Abidin ◽  
Mohaideen Sitheeque ◽  
Md Azman PKM Seeni Mohamad
Keyword(s):  
Dental Plaque ◽  
Taste Perception ◽  
P Value ◽  
Mouth Rinse ◽  
Calendula Officinalis ◽  
Double Blind ◽  
Plaque Score ◽  
Hygiene Practices ◽  
Index Measurement ◽  
Tooth Surfaces

Introduction: An ideal mouth rinse must have an acceptable taste and very efficient antiplaque activity. Herbal mouth rinse (Plandula®), containing extracts of Calendula officinalis and other specified herbs, is widely cultivated as a herb. It is a remarkable healing agent and even useful to act as homeopathic remedies. Previous studies have compared this product with placebo; however, comparison against chlorhexidine have not been conducted thus far. Aim of this research was to analyse the efficacy of Calendula in Plandula® for controlling dental plaque and the acceptability of its taste in comparison with chlorhexidine. Methods: A double-blind, 3-day plaque regrowth, crossover, clinical study was conducted towards 16 volunteers participated in two periods, three days each, with modified oral hygiene practices through an intervening washout period of 4 days. At the commencement of each period, the participants received oral prophylaxis. They used the allocated mouth rinse and brushed teeth without toothpaste in all of the tooth surfaces, except palatal and lingual over three days. On the fourth day, the subjects were returned for plaque index measurement only on the palatal and lingual surfaces by the Quigley Hein index (modified by Turesky). The participants rinsed with 10 ml of allocated mouth rinse three times daily for 30 seconds after tooth brushing. The participants followed the same steps during the second period using the alternate mouth rinse. They were also asked to taste both mouth rinses and evaluate with a Visual Analogue Scale (VAS).Results: Median plaque score for Plandula® mouth rinse was slightly higher compared to chlorhexidine but not statistically significant, with the p-value=0.636 (p>0.05). The mean VAS scale score for Plandula® taste perception was lower than the chlorhexidine, and statistically significant (p-value=0.01; p<0.05). Conclusion: Plandula® mouth rinse that contain calendula officinalis comparable with chlorhexidine in controlling dental plaque accumulation, with an acceptable taste.

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