Hop Bract Polyphenols Reduced Three-day Dental Plaque Regrowth

2007 ◽  
Vol 86 (9) ◽  
pp. 848-851 ◽  
Author(s):  
K. Shinada ◽  
M. Tagashira ◽  
H. Watanabe ◽  
P. Sopapornamorn ◽  
A. Kanayama ◽  
...  
Keyword(s):  
Clinical Study ◽  
Oral Hygiene ◽  
Dental Plaque ◽  
Mutans Streptococci ◽  
Healthy Male ◽  
Inhibitory Effects ◽  
Performance Score ◽  
Double Blind ◽  
The Mean

Previous research has shown the inhibitory effects of hop bract polyphenols (HBP) on cariogenic streptococci in vitro, but their effects in humans have not been investigated. This double-blind, crossover clinical study tested the hypothesis that HBP delivered in a mouthrinse suppresses plaque regrowth in humans. Twenty-nine healthy male volunteers had all plaque removed, and refrained from all oral hygiene for 3 days, except for rinsing with a mouthrinse containing 0.1% HBP or a placebo. The results showed that the mean amount of plaque assessed by the Patient Hygiene Performance score after the volunteers used the HBP mouthrinse was significantly less than that after they used the placebo (p < 0.001). The number of mutans streptococci in the plaque samples after volunteers used the HBP mouthrinse was significantly lower than that after they used the placebo (p < 0.05). These findings suggested that HBP, delivered in a mouthrinse, successfully reduced dental plaque regrowth in humans.

Caries Inhibitory Activity of the Nano-HA In Vitro

2007 ◽  
Vol 330-332 ◽  
pp. 251-254 ◽  
Author(s):  
Xiang Cai Meng ◽  
Kui Long Lv ◽  
Jiu Xing Zhang ◽  
Da Li Qu
Keyword(s):  
Dental Plaque ◽  
Bacterial Colonization ◽  
Lactobacillus Rhamnosus ◽  
Bacterial Consortium ◽  
Inhibitory Effects ◽  
Streptococcus Sanguis ◽  
Acid Generation ◽  
Continuous Culture System ◽  
Early Caries

The purpose of this study is to examine the inhibitory effects of nano-HA on the caries-inducing properties of a four-organism bacterial consortium in vitro. A series of in vitro anticarious experiments have been carried out by using a continuous culture system. Streptococcus mutans, Streptococcus sanguis, Actinomyces viscosus, Lactobacillus rhamnosus have been chosen as the experimental bacteria. After 48 hours, the dental plaque surface structure is observed with the scan electron microscope and the bacterial colonization was evaluated on dental plaque. The results show that Spherical nano-HA and mixed nano-HA are proved to be effective in anticarious experiments, and especially spherical nano-HA is more striking. It is able to damage the formation of biofilms (dental plaque), postpone or end the process of acid generation of bacteria metabolism. After 7 days, the demineralization of the enamel has been detected by using TEM. The spherical nano-HA might have a remineralization to early caries to prevent and decrease caries.

A phase I pharmacokinetics trial comparing PF-05280014 (a potential biosimilar) and trastuzumab in healthy volunteers (REFLECTIONS B327-01).

2013 ◽  
Vol 31 (26_suppl) ◽  
pp. 171-171 ◽  
Author(s):  
Donghua Yin ◽  
Kerry B. Barker ◽  
Ruifeng Li ◽  
Xu Meng ◽  
Steven D. Reich ◽  
...  
Keyword(s):  
Double Blind Trial ◽  
Healthy Male ◽  
Double Blind ◽  
Treatment Interruptions ◽  
The Us ◽  
Identical Amino Acid Sequence ◽  
To Receive ◽  
Clinical Trial Information ◽  
Time Point

171 Background: PF-05280014, a proposed biosimilar to trastuzumab, has an identical amino acid sequence and similar physicochemical and in vitro functional properties to trastuzumab. This study was designed to demonstrate PK similarity of PF-05280014 to trastuzumab from the US (trastuzumab-US) and EU (trastuzumab-EU), and between the licensed drugs. Safety and immunogenicity were also evaluated. Methods: In this double-blind trial (NCT01603264), 105 healthy male volunteers, 18-55 years old were randomized 1:1:1 to receive a single 6 mg/kg IV dose of PF-05280014, trastuzumab-US or trastuzumab-EU. All subjects provided informed consent. PK, safety and immunogenicity assessments were conducted for 70 days. PK similarity for a given test-to-reference comparison was considered to be demonstrated if the 90% CI of the test-to-reference ratio of the AUC from time 0 to the last time point (AUCT) and maximum concentration (Cmax) were within 80% – 125%. Results: The baseline demographics for the 101 subjects evaluable for PK were similar among 3 treatment arms. The 3 study drugs exhibited similar characteristics of target-mediated disposition and similar PK parameters (Table). The 90% CI for the ratios of Cmax, AUCT, and AUC0-∞were within 80% – 125% for the comparisons of PF-05280014 to trastuzumab-EU or trastuzumab-US, and trastuzumab-EU to trastuzumab-US. Adverse events (AE) were similar for the 3 arms with treatment-related AEs reported by 71.4%, 68.6%, and 65.7% subjects in the PF-05280014, trastuzumab-EU and trastuzumab-US, respectively. No serious AEs were reported. Only 4 subjects had treatment interruptions; 2 discontinued. Only 1 subject (trastuzumab-EU) developed anti-drug antibodies after dosing. Conclusions: This study demonstrates PK similarity of PF-05280014 to both trastuzumab-US and trastuzumab-EU and of trastuzumab-EU to trastuzumab-US. The 3 study drugs also showed similar safety profiles. Clinical trial information: NCT01603264. [Table: see text]

Relationships between dietary behaviours, oral hygiene and mutans streptococci in dental plaque of a group of infants in southern England

2002 ◽  
Vol 47 (6) ◽  
pp. 491-498 ◽  
Author(s):  
Mina Habibian ◽  
David Beighton ◽  
Rebecca Stevenson ◽  
Margaret Lawson ◽  
Graham Roberts
Keyword(s):  
Oral Hygiene ◽  
Dental Plaque ◽  
Mutans Streptococci ◽  
Southern England ◽  
Dietary Behaviours

scholarly journals The Effects of an Alum-containing Mouthrinse and a Saturated Saline Rinse on Existing Plaque Levels in Children

2015 ◽  
Vol 5 (1) ◽  
pp. 7-11
Author(s):  
Jasmin Winnier ◽  
Ullal Anand Nayak ◽  
Arun Prasad Rao ◽  
Venugopal N Reddy
Keyword(s):  
Statistical Analysis ◽  
Oral Hygiene ◽  
Dental Plaque ◽  
Plaque Index ◽  
Control Group ◽  
Double Blind ◽  
Professional Supervision ◽  
Hygiene Measures

ABSTRACT Aims and objectives The present study compared and evaluated the effects of an alum-containing mouthrinse and a saturated saline rinse on existing plaque levels in children. Materials and Methods The investigation was a double blind, stratified comparison of three parallel groups of children who used either an alum-containing mouthrinse or a saturated saline rinse twice daily under professional supervision for a 21 days period. Dental plaque was recorded using the plaque index described by Silness and Loe at baseline, on days 10 and 21. Statistical analysis All data were subjected to statistical analysis using Wilcoxon's signed ranks sum test and Mann- Whitney U-test. Results and conclusion The results of the present study show that alum and saturated saline mouthrinse groups showed statistically significant reductions in dental plaque levels on comparison of the data obtained at baseline, 10th and 21st days over the control group. Among the two adjunctive oral hygiene measures that were evaluated, alum rinse was the most effective in reducing the dental plaque levels. How to cite this article Rupesh S, Winnier J, Nayak UA, Rao AP, Reddy VN. The Effects of an Alum-containing Mouthrinse and a Saturated Saline Rinse on Existing Plaque Levels in Children. J Contemp Dent 2015;5(1):7-11.

scholarly journals Effect of Oral Care Protocol on Dental and Gingival Plaque Index in Patients With Endotracheal Tube Admitted to the Intensive Care Unit

2021 ◽  
Author(s):  
Ali Ghaempanah ◽  
Mitra Payami Bosari ◽  
Abolfazl Amini ◽  
Soqrat Faghihzadeh ◽  
Zahra Aghazadeh
Keyword(s):  
Oral Health ◽  
Dental Plaque ◽  
Oral Care ◽  
Plaque Index ◽  
Control Group ◽  
Control Groups ◽  
Double Blind ◽  
Care Protocol ◽  
The Mean ◽  
And Control

Oral health is one of the most critical aspects of nursing care in critically ill patients. The study aimed to investigate the effect of oral health protocol on dental and gingival plaque index in patients with endotracheal tubes admitted into the ICU. This double-blind clinical trial was conducted on 70 patients admitted into ICU randomly by tossing a coin, and 35 patients were assigned to each of the experimental and control groups. Oral care was performed in the experimental group using the chlorhexidine (CHX) solution, toothpaste, and oral moisturizer protocol; in the control group, according to the routine method, 0.2% CHX was used twice a day. The data were collected at the time of inclusion and four days later, using the MGI and the O'Leary dental plaque index. The mean ages in the experimental and control groups were 38.4±14.4 and 41±14.5 years, respectively. In the experimental and control groups, 77% and 83% of the subjects were male, respectively. After the intervention, the mean gingival index in the experimental and control groups was 0.59±0.31 and 0.90±0.41, and the plaque index was 42.53±15.97 and 53.52±11.9, respectively. The differences before and after the intervention in each group and the difference between the two groups in both gingival and dental plaque indices were statistically significant (P=0.0001). The results showed that the oral health protocol was more effective in improving gingival and dental plaque indices than the routine (CHX) method.

Pharmacokinetics of Saruplase, a Recombinant Unglycosylated Human Single-Chain Urokinase-Type Plasminogen Activator and Its Effects on Fibrinolytic and Haemostatic Parameters in Healthy Male Subjects

1993 ◽  
Vol 70 (02) ◽  
pp. 320-325 ◽  
Author(s):  
A de Boer ◽  
C Kluft ◽  
J Gerloff ◽  
G Dooijewaard ◽  
W A Günzler ◽  
...  
Keyword(s):  
Plasminogen Activator ◽  
Degradation Products ◽  
Healthy Male ◽  
Single Chain ◽  
Plasminogen Activator Inhibitor 1 ◽  
Double Blind ◽  
Type Plasminogen Activator ◽  
Urokinase Type Plasminogen Activator ◽  
Male Subjects

SummaryPharmacokinetics of two doses of the recombinant single-chain urokinase-type plasminogen activator (r-scu-PA) saruplase (40 and 20 mg) and its effect on fibrinolytic and haemostatic parameters were studied in six healthy male subjects using a randomized, double-blind, placebo-controlled, cross-over study. Special precautions were taken to prevent artefactual in vitro effects on fibrinolytic activity.The clearance of saruplase ranged from 310 to 862 ml/min and the apparent volume of distribution of the central compartment was about 8 1. Both doses of saruplase caused α2-antiplasmin consumption, indicating some systemic fibrinolytic activation. However, the 20 mg dose caused no detectable fibrinogen breakdown and only a small increase in total fibrin/fibrinogen degradation products (TDP) (from 0.16 μg/ml [range 0.14 to 0.19] to 0.78 μg/ml [range 0.56 to 1.26]), while the 40 mg dose produce a fibrinogen breakdown to an average value of 44% (range 19 to 60%) and TDP increased from 0.12 μg/ml (range 0.11–0.12) to 2.29 μg/ml (range 0.45 to 5.55). The breakdown of fibrinogen was related to the quantity of saruplase converted to active two-chain u-PA (tcu-PA) in vivo (6 to 22% conversion). There were no important effects of saruplase on overall blood coagulation (activated partial thromboplastin time) and platelet function (collagen induced platelet aggregation, urinary [2,3-dinor]-thromboxane B2 excretion and plasminogen activator inhibitor 1 [PAI-1] release from platelets).Saruplase is cleared rapidly from the plasma and a variable amount is converted to tcu-PA. This two-chain form of u-PA probably causes the dose-dependent systemic fibrinolytic activation.

Sign in / Sign up

Export Citation Format

Share Document