Risk factors for renal dysfunction in adult patients with short bowel syndrome

Renal impairment is a common complication in patients with intestinal failure that is mostly caused by short bowel syndrome (SBS) and is associated with adverse outcomes that severely affect the quality of life or even survival. The prevalence and risk factors for renal impairment in patients with SBS remain unclarified. Therefore, we aimed to determine the prevalence of renal impairment and identify potential risk factors for renal impairment in adult patients with SBS. We retrospectively identified 199 patients diagnosed with SBS admitted to the Department of General Surgery between January 1, 2012 and January 1, 2019, from a prospectively maintained database. Overall, 56 patients (28.1%) with decreased renal function (eGFR < 90 mL/min/1.73 m2). The median duration of SBS was 7 months (IQR, 3–31 months) and the mean eGFR was 103.1 ± 39.4 mL/min/1.73 m2. Logistic regression modeling indicated that older age [odds ratio (OR), 1.074; 95% CI, 1.037–1.112, P < 0.001], kidney stones (OR, 4.887; 95% CI, 1.753–13.626; P = 0.002), decreased length of the small intestine (OR, 0.988; 95% CI, 0.979–0.998; P = 0.019), and prolonged duration of SBS (OR, 1.007; 95% CI, 1.001–1.013; P = 0.046) were significant risk factors for renal impairment. This is the largest study that has specifically explored the risk factors for renal impairment in a large cohort of adults with SBS. The present study showed that renal function should be closely monitored during treatment, and patients should be given prophylactic interventions if necessary. This retrospective study is a part of clinical study NCT03277014, registered in ClinicalTrials.gov PRS. And the PRS URL is http://register.clinicaltrials.gov.

Download Full-text

Candidacy of adult patients with short bowel syndrome for treatment with glucagon-like peptide-2 analogues: A systematic analysis of a single centre cohort

Clinical Nutrition ◽

10.1016/j.clnu.2021.02.011 ◽

2021 ◽

Author(s):

Loris Pironi ◽

Anna Simona Sasdelli ◽

Francesca Maria Venerito ◽

Alessandra Musio ◽

Caterina Pazzeschi ◽

...

Keyword(s):

Short Bowel Syndrome ◽

Adult Patients ◽

Single Centre ◽

Systematic Analysis ◽

Short Bowel ◽

Glucagon Like Peptide

Download Full-text

Equative: quality of life in adult patients with short bowel syndrome treated by teduglutide, a french real-world study

Clinical Nutrition ESPEN ◽

10.1016/j.clnesp.2021.09.346 ◽

2021 ◽

Vol 46 ◽

pp. S665

Author(s):

F. Joly ◽

D. Quilliot ◽

C. Chambrier ◽

S. Schneider ◽

G. Fotsing ◽

...

Keyword(s):

Quality Of Life ◽

Short Bowel Syndrome ◽

Real World ◽

Adult Patients ◽

Short Bowel

Download Full-text

Prevalence, Risk Factors, and Complications of Cholelithiasis in Adults With Short Bowel Syndrome: A Longitudinal Cohort Study

Frontiers in Nutrition ◽

10.3389/fnut.2021.762240 ◽

2021 ◽

Vol 8 ◽

Author(s):

Xuejin Gao ◽

Li Zhang ◽

Siwen Wang ◽

Yaqin Xiao ◽

Deshuai Song ◽

...

Keyword(s):

Risk Factors ◽

Short Bowel Syndrome ◽

Proportional Hazards ◽

Proportional Hazards Model ◽

Cox Proportional Hazards ◽

Cox Proportional Hazards Model ◽

Clinical Trial Registration ◽

Short Bowel ◽

Kaplan Meier ◽

Clinical Consequences

Background: Patients with short bowel syndrome (SBS) are at a high risk of cholestasis or cholelithiasis. This study aimed to determine the incidence, risk factors, and clinical consequences of cholelithiasis in adults with SBS over an extended period.Methods: All eligible adults diagnosed with SBS and admitted to a tertiary hospital center between January 2010 and December 2019 were retrospectively identified from the hospital records database. Kaplan–Meier analysis was used to estimate the cumulative incidence of SBS during the 10-year period. For assessment the risk factors for cholelithiasis, we used multivariate Cox proportional hazards model with estimation of hazard ratio (HR) with 95% confidence intervals (95 %CI).Results: This study enrolled 345 eligible patients with SBS. Kaplan–Meier analysis revealed that 72 patients (20.9%) developed cholelithiasis during the 10-year observation period. In multivariate analyses using the Cox proportional hazard model revealed that the remnant jejunum (HR = 2.163; 95% confidence interval [CI]: 1.156–4.047, p = 0.016) and parenteral nutrition dependence (HR = 1.783; 95% CI: 1.077–2.952, p = 0.025) were independent risk factors for cholelithiasis in adults with SBS. Twenty-eight patients developed symptoms and/or complications in the cholelithiasis group. Proportions of acute cholecystitis or cholangitis and acute pancreatitis were significantly increased in the cholelithiasis group compared with the non-cholelithiasis group (31.9 vs. 7.7%, p < 0.01; and 6.9 vs. 1.1%, p = 0.003, respectively).Conclusion: Because of the adverse clinical consequences of cholelithiasis, adult patients with SBS should be closely monitored, and preventive interventions should be considered.Clinical Trial Registration:www.ClinicalTrials.gov, identifier: NCT04867538.

Download Full-text

Risk Factors for Nephrolithiasis in Adults with Short Bowel Syndrome

Annals of Nutrition and Metabolism ◽

10.1159/000502329 ◽

2019 ◽

Vol 75 (1) ◽

pp. 47-54 ◽

Cited By ~ 1

Author(s):

Jianbo Yang ◽

Haifeng Sun ◽

Songlin Wan ◽

Gulsudum Mamtawla ◽

Xuejin Gao ◽

...

Keyword(s):

Risk Factors ◽

Short Bowel Syndrome ◽

Binary Logistic Regression ◽

Binary Logistic Regression Analysis ◽

Creatinine Concentration ◽

Short Bowel ◽

Tertiary Referral Center ◽

Prolonged Duration ◽

Clinical Consequences ◽

The Mean

Introduction: Patients with short bowel syndrome (SBS) commonly develop nephrolithiasis. However, the risk factors for nephrolithiasis in patients with SBS remain unclarified. The present study aimed to identify the risk factors for nephrolithiasis in adults with SBS. Methods: All eligible adults diagnosed with SBS and admitted to a tertiary referral center from December 2008 to 2018 were retrospectively identified from a prospectively maintained database. Patients’ demographic and clinical characteristics were analyzed using univariate and multivariate analyses to identify the risk factors for nephrolithiasis. Results: Of 231 adults with SBS, 42 (18.2%) developed nephrolithiasis. The mean age was 46.4 ± 17.8 years, the mean body mass index was 18.2 ± 3.8 kg/m2, and median duration of SBS was 11 months (range 2–324 months). Multivariate binary logistic regression analysis revealed that the independent risk factors for nephrolithiasis in adults with SBS were jejuno-ileal anastomosis and colon-in-continuity (OR 4.335; 95% CI 1.175–16.002; p = 0.028), prolonged duration of SBS (OR 1.008; 95% CI 1.002–1.014; p = 0.010), and increased serum creatinine concentration (OR 1.005; 95% CI 1.001–1.009; p = 0.012). Conclusions: Nephrolithiasis is common in adults with SBS. As nephrolithiasis can have adverse clinical consequences, patients with SBS should be closely monitored, and prophylactic interventions should be considered.

Download Full-text