Nutritional profile of oropharyngeal cancer patients according to HPV status

Infection with the human papillomavirus (HPV) has been identified as a major risk factor for oropharyngeal cancer (OPC). HPV-related OPCs have been shown to be more radiosensitive and to have a reduced risk for cancer related death. Hence, the histological determination of HPV status of cancer patients depicts an essential diagnostic factor. We investigated the ability of deep learning models for imaging based HPV status detection. To overcome the problem of small medical datasets, we used a transfer learning approach. A 3D convolutional network pre-trained on sports video clips was fine-tuned, such that full 3D information in the CT images could be exploited. The video pre-trained model was able to differentiate HPV-positive from HPV-negative cases, with an area under the receiver operating characteristic curve (AUC) of 0.81 for an external test set. In comparison to a 3D convolutional neural network (CNN) trained from scratch and a 2D architecture pre-trained on ImageNet, the video pre-trained model performed best. Deep learning models are capable of CT image-based HPV status determination. Video based pre-training has the ability to improve training for 3D medical data, but further studies are needed for verification.

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Pre-radiotherapy dental status of oropharyngeal cancer patients based on HPV status in a novel radiation era

BDJ ◽

10.1038/s41415-020-1922-y ◽

2020 ◽

Cited By ~ 1

Author(s):

Vinod Patel ◽

Dipesh Patel ◽

Timothy Browning ◽

Sheelen Patel ◽

Mark McGurk ◽

...

Keyword(s):

Cancer Patients ◽

Oropharyngeal Cancer ◽

Dental Status ◽

Hpv Status

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Prognostic markers for oropharyngeal cancer after docetaxel, 5-FU, and cisplatin induction chemotherapy followed by concurrent chemoradiotherapy.

Journal of Clinical Oncology ◽

10.1200/jco.2013.31.15_suppl.e17005 ◽

2013 ◽

Vol 31 (15_suppl) ◽

pp. e17005-e17005

Author(s):

Sang-Hee Cho ◽

Woo Kyun Bae ◽

Hyun-Jeong Shim ◽

Won-young Choi ◽

Jun-Eul Hwang ◽

...

Keyword(s):

Cancer Patients ◽

Induction Chemotherapy ◽

Oropharyngeal Cancer ◽

Univariate Analysis ◽

Locally Advanced ◽

Surrogate Marker ◽

Hpv Infection ◽

Response Analysis ◽

P16 Protein ◽

Hpv Status

e17005 Background: HPV is associated with prognosis of oropharyngeal cancer, and the incidence has been increased in not only western countries, but also Asian. This study aims to assess the prognostic role of HPV expression and clinical factors after induction chemotherapy followed by chemoradiotherapy for locally advanced oropharyngeal cancer in Korean patients. Methods: A retrospective review of 74 patients with known HPV status and treated with the induction chemotherapy of docetaxel, cisplatin and 5-FU followed by chemoradiotherapy was performed. HPV infection was evaluated with in situ hybridization (ISH) for HPV and p16 protein expression. Results: The median age is 65 (range 43-80) years with male 69, female 5. Among them, 36 patients (49%) are current smokers and 17 patients (23%) are heavy drinkers. Nine patients (12%) show HPV positive in ISH and 35 patients (47%) expressed p16 protein. In response analysis, there is an increasing trend of complete response (CR) in p16 positive patients (34.3%) compared with p16 negative patients (17.9%; P=0.055). HPV expression had no significance with CR. Tumor recurrence showed significantly higher in HPV-negative patients (P=0.044) and p16 (P=0.015) than HPV and p16 positive patients, respectively. In survival analysis, even though the median value was not reached until this time, it showed better trend of PFS in p16 positive patients than p16 negative patients (P=0.072). In univariate analysis of HPV status and clinical parameters, the expression of p16 or HPV had no significant association with survival. However, performance status (PS), T staging, tumor response are significant factors associated with PFS. And PS (0 vs. 1-2) showed a strong relation with PFS in multivariate analysis (HR: 0.24, P=0.001) Conclusions: p16 is a prognostic marker for oropharyngeal cancer patients treated with triple induction chemotherapy followed by CRT and it would be a better surrogate marker for HPV infection than HPV ISH. In addition to biomarker, clinical parameter such as PS has been still important factor of treatment outcome in oropharyngeal cancer patients.

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Potential clinical implications of HPV status and expressions of p53 and cyclin D1 among oropharyngeal cancer patients

Journal of Oral Pathology and Medicine ◽

10.1111/jop.12779 ◽

2018 ◽

Vol 47 (10) ◽

pp. 945-953 ◽

Cited By ~ 6

Author(s):

X. J. David Lu ◽

Kelly Y. P. Liu ◽

Rosilene C. Soares ◽

Thomas Thomson ◽

Eitan Prisman ◽

...

Keyword(s):

Cyclin D1 ◽

Cancer Patients ◽

Oropharyngeal Cancer ◽

Clinical Implications ◽

Hpv Status

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Metachronous second primary neoplasia in oropharyngeal cancer patients: Impact of tumor HPV status. A GETTEC multicentric study

Oral Oncology ◽

10.1016/j.oraloncology.2021.105503 ◽

2021 ◽

Vol 122 ◽

pp. 105503

Author(s):

Florent Milliet ◽

Alexandre Bozec ◽

Renaud Schiappa ◽

Julien Viotti ◽

Anouchka Modesto ◽

...

Keyword(s):

Cancer Patients ◽

Oropharyngeal Cancer ◽

Second Primary ◽

Multicentric Study ◽

Hpv Status

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HPV status predicts survival of oropharyngeal cancer patients

Cancer ◽

10.1002/cncr.24650 ◽

2009 ◽

Vol 115 (18) ◽

pp. 4045-4045

Author(s):

Carrie Printz

Keyword(s):

Cancer Patients ◽

Oropharyngeal Cancer ◽

Hpv Status

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Comparison of Selected Immune and Hematological Parameters and Their Impact on Survival in Patients with HPV-Related and HPV-Unrelated Oropharyngeal Cancer

Cancers ◽

10.3390/cancers13133256 ◽

2021 ◽

Vol 13 (13) ◽

pp. 3256

Author(s):

Adam Brewczyński ◽

Beata Jabłońska ◽

Agnieszka Maria Mazurek ◽

Jolanta Mrochem-Kwarciak ◽

Sławomir Mrowiec ◽

...

Keyword(s):

Prognostic Factors ◽

Oropharyngeal Cancer ◽

Hematological Parameters ◽

White Blood Cells ◽

Post Treatment ◽

Neutrophil Lymphocyte Ratio ◽

Lymphocyte Ratio ◽

Hpv Status ◽

Pre Treatment ◽

The Impact

Several immune and hematological parameters are associated with survival in patients with oropharyngeal cancer (OPC). The aim of the study was to analyze selected immune and hematological parameters of patients with HPV-related (HPV+) and HPV-unrelated (HPV-) OPC, before and after radiotherapy/chemoradiotherapy (RT/CRT) and to assess the impact of these parameters on survival. One hundred twenty seven patients with HPV+ and HPV− OPC, treated with RT alone or concurrent chemoradiotherapy (CRT), were included. Patients were divided according to HPV status. Confirmation of HPV etiology was obtained from FFPE (Formalin-Fixed, Paraffin-Embedded) tissue samples and/or extracellular circulating HPV DNA was determined. The pre-treatment and post-treatment laboratory blood parameters were compared in both groups. The neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), monocyte/lymphocyte ratio (MLR), and systemic immune inflammation (SII) index were calculated. The impact of these parameters on overall (OS) and disease-free (DFS) survival was analyzed. In HPV+ patients, a high pre-treatment white blood cells (WBC) count (>8.33 /mm3), NLR (>2.13), SII (>448.60) significantly correlated with reduced OS, whereas high NLR (>2.29), SII (>462.58) significantly correlated with reduced DFS. A higher pre-treatment NLR and SII were significant poor prognostic factors for both OS and DFS in the HPV+ group. These associations were not apparent in HPV− patients. There are different pre-treatment and post-treatment immune and hematological prognostic factors for OS and DFS in HPV+ and HPV− patients. The immune ratios could be considered valuable biomarkers for risk stratification and differentiation for HPV− and HPV+ OPC patients.

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