Retropharyngeal lymph node involvement in oropharyngeal cancer: Impact on risk of distant metastases and survival

The influence of retropharyngeal lymph node (RPLN) involvement on prognosis in oropharyngeal carcinoma remains poorly defined. The aim of this study was to assess the impact of RPLN involvement upon outcomes. A single-centre retrospective analysis of 402 patients with oropharyngeal carcinoma treated nonsurgically between 2010 and 2017 was performed. All had a baseline 2-[fluorine-18]-fluoro-2-deoxy-d-glucose (FDG) PET-CT and contrast-enhanced MRI and/or CT. RPLN status was determined by radiology review of cases with reported abnormal RPLN. Multivariate backwards logistic regression was used to examine impact on outcomes of factors. Abnormal RPLNs were identified in 40/402 (10%) of patients. Median follow up was 42.9 months. RPLN involvement was associated with inferior 3 year outcomes for overall survival (OS) (67.1% vs. 79.1%, p = 0.006) and distant metastases-free survival (DMFS) (73.9% versus 88.0%, p = 0.011), with no significant difference in local control (81.6% vs. 87.7%, p = 0.154) or regional control (80.7% vs. 85.4%, p = 0.252). On multivariate analysis abnormal RPLN, no concurrent chemotherapy and ongoing smoking were associated with inferior DMFS and OS, while advanced T stage was also associated with inferior OS. In summary, RPLN involvement, present in 10% of patients, was an independent prognostic factor for the development of distant disease failure translating into inferior OS. These findings need confirmation in future studies.

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Small Intestine: Adenocarcinoma

10.2310/7800.16092 ◽

2017 ◽

Author(s):

Joel M Baumgartner ◽

Sudeep Banerjee ◽

Jason K Sicklick

Keyword(s):

Lymph Node ◽

Small Bowel ◽

Systemic Chemotherapy ◽

Imaging Techniques ◽

Distant Metastases ◽

Lymph Node Involvement ◽

Small Bowel Adenocarcinoma ◽

Stage Disease ◽

Node Involvement ◽

Inflammatory Bowel

Adenocarcinoma is the second most common nonduodenal small bowel tumor. Small bowel adenocarcinoma has risk factors similar to those of colorectal adenocarcinoma but is rarer and less well understood. Diagnosis relies on advanced imaging techniques as well as endoscopy or enteroscopy for tissue diagnosis. Aggressive biology and vague symptoms in early disease cause a majority of patients to present with late-stage disease. Adenocarcinomas with lymph node involvement should be treated with resection and systemic chemotherapy. In contrast, systemic chemotherapy alone should be employed in cases with distant metastases unless the primary tumor is bleeding, perforated, or causing a bowel obstruction. This review contains 4 figures, 5 tables and 17 references Key words: adenocarcinoma, chemotherapy, enteroscopy, hereditary syndrome, inflammatory bowel disease, lymph node, mesentery, small bowel

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Small Intestine: Adenocarcinoma

10.2310/cgso.16092 ◽

2017 ◽

Author(s):

Joel M Baumgartner ◽

Sudeep Banerjee ◽

Jason K Sicklick

Keyword(s):

Lymph Node ◽

Small Bowel ◽

Systemic Chemotherapy ◽

Imaging Techniques ◽

Distant Metastases ◽

Lymph Node Involvement ◽

Small Bowel Adenocarcinoma ◽

Stage Disease ◽

Node Involvement ◽

Inflammatory Bowel

Adenocarcinoma is the second most common nonduodenal small bowel tumor. Small bowel adenocarcinoma has risk factors similar to those of colorectal adenocarcinoma but is rarer and less well understood. Diagnosis relies on advanced imaging techniques as well as endoscopy or enteroscopy for tissue diagnosis. Aggressive biology and vague symptoms in early disease cause a majority of patients to present with late-stage disease. Adenocarcinomas with lymph node involvement should be treated with resection and systemic chemotherapy. In contrast, systemic chemotherapy alone should be employed in cases with distant metastases unless the primary tumor is bleeding, perforated, or causing a bowel obstruction. This review contains 4 figures, 5 tables and 17 references Key words: adenocarcinoma, chemotherapy, enteroscopy, hereditary syndrome, inflammatory bowel disease, lymph node, mesentery, small bowel

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Incidence and patterns of retropharyngeal lymph node involvement in oropharyngeal carcinoma

Radiotherapy and Oncology ◽

10.1016/j.radonc.2019.07.021 ◽

2020 ◽

Vol 142 ◽

pp. 92-99 ◽

Cited By ~ 2

Author(s):

Zsuzsanna Iyizoba-Ebozue ◽

Louise J. Murray ◽

Moses Arunsingh ◽

Sriram Vaidyanathan ◽

Andrew F. Scarsbrook ◽

...

Keyword(s):

Lymph Node ◽

Lymph Node Involvement ◽

Oropharyngeal Carcinoma ◽

Retropharyngeal Lymph Node ◽

Node Involvement

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Impact of 18F-FDG PET/CT on the staging of patients with non-small cell lung cancer

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20202237 ◽

2020 ◽

Vol 8 (6) ◽

pp. 2023

Author(s):

Ngo Minh Xuan ◽

Huynh Quang Huy

Keyword(s):

Lymph Node ◽

Tumor Size ◽

Distant Metastases ◽

Large Cell ◽

Lymph Node Involvement ◽

Emission Tomography ◽

Small Cell Lung ◽

Positron Emission ◽

Node Involvement ◽

Group 3

Background: Non-small cell lung cancer (NSCLC) accounts for approximately 80% of new diagnoses of pulmonary carcinoma. This study investigated the correlation between 18 F-fluorodeoxyglucose uptake in computerized tomography integrated positron emission tomography and tumor size, lymph node metastasis, and distant metastasis in patients with NSCLC.Methods: The records of 318 NSCLC patients (220 male, 98 females; mean age 60.94 years) were evaluated retrospectively.Results: 278 cases were adenocarcinomas; 28 squamous cell carcinomas; and 12 large cell carcinoma. When the cases were categorized according to tumor size (group 1, ≤3 cm; group 2, >3 and ≤5 cm; group 3, >5 cm), the maximum standardized uptake value (SUVmax) was significantly lower in groups 1 and 2 compared with group 3 (p<0,001 for each). Considering all cases, tumor SUVmax was not correlated with age, gender or histopathological type. Lymph node metastases were seen in 250 cases: 80.2% of these were adenocarcinomas, 71.4% squamous cell carcinomas, and 58.3% large cell carcinomas. Neither lymph node involvement nor distant metastases were correlated with tumor SUVmax, although lymph node size was positively correlated with lymph node SUVmax (r=0.758; p<0.001).Conclusions: SUVmax was significantly associated with tumor size, but not with distant metastases or lymph node involvement. Therefore, SUVmax on positron emission tomography is not predictive of the presence of metastases.

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Changing trends of incidence and prognosis of thyroid carcinoma

Nuklearmedizin ◽

10.1055/a-0859-7454 ◽

2019 ◽

Vol 58 (02) ◽

pp. 86-92 ◽

Cited By ~ 2

Author(s):

Jamshid Farahati ◽

Uwe Mäder ◽

Elena Gilman ◽

Rainer Görges ◽

Ines Maric ◽

...

Keyword(s):

Thyroid Cancer ◽

Lymph Node ◽

Distant Metastases ◽

Tumor Stage ◽

Lymph Node Involvement ◽

Population Based ◽

Management Algorithm ◽

Node Involvement ◽

T1 And T2 ◽

Lower Franconia

Abstract Aim to evaluate the time trend of epidemiology of follicular cell derived thyroid cancer (TC) based on data from a well documented cancer registry. Methods Population based data on TC from Lower Franconia (LF), Germany, within 1981 and 2015 were analysed to estimate the regional epidemiology of TC. The incidence was assessed in 5-year-intervals for gender, histology, and tumor stage. Results Incidence of TC solely attributable to papillary TC (PTC) doubled mainly in T1- and T2-stages within the evaluation period from 4.5 to 8.7/100.000/y in females and 1.7 to 4.1/100.000/y in males. There was no significant change of follicular TC (FTC), whereas anaplastic TC (ATC) decreased in the same interval. The number of lymph-node metastases and T3-cases increased, while the frequency of T4-stage and distant metastases decreased. Increased incidences of T1- and T2-stages suggest an over-diagnosis. In contrast, increasing number of tumors at T3-stage and with lymph node involvement contradict the over-diagnosis as the only reason for rising incidence. Declining of T4-stages in spite of increasing of T3-stages and N1-cases indicates the value of timely detection and treatment of TC. In accordance, reduced incidence of advanced cancers with M1-stage and ATC cases promote our current management of TC. Conclusion Timely diagnosis and adequate risk-adopted treatment of thyroid cancer reduce the frequency of high-risk cases with distant metastases and the possible protracted dedifferentiation of TC to anaplastic features. Our analyses support the management algorithm in thyroid cancer according to the recent guidelines of German Nuclear Medicine Society.

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