Geodesic Fiber Tracking in White Matter using Activation Function

Object Resecting brain tumors involves the risk of damaging the descending motor pathway. Diffusion tensor (DT)–imaged fiber tracking is a noninvasive magnetic resonance (MR) technique that can delineate the subcortical course of the motor pathway. The goal of this study was to use intraoperative subcortical stimulation mapping of the motor tract and magnetic source imaging to validate the utility of DT-imaged fiber tracking as a tool for presurgical planning. Methods Diffusion tensor-imaged fiber tracks of the motor tract were generated preoperatively in nine patients with gliomas. A mask of the resultant fiber tracks was overlaid on high-resolution T1- and T2-weighted anatomical MR images and used for stereotactic surgical navigation. Magnetic source imaging was performed in seven of the patients to identify functional somatosensory cortices. During resection, subcortical stimulation mapping of the motor pathway was performed within the white matter using a bipolar electrode. Results A total of 16 subcortical motor stimulations were stereotactically identified in nine patients. The mean distance between the stimulation sites and the DT-imaged fiber tracks was 8.7 ±3.1 mm (±standard deviation). The measured distance between subcortical stimulation sites and DT-imaged fiber tracks combines tracking technique errors and all errors encountered with stereotactic navigation. Conclusions Fiber tracks delineated using DT imaging can be used to identify the motor tract in deep white matter and define a safety margin around the tract.

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Combining fiber tracking and functional brain imaging for revealing brain networks involved in auditory–visual integration in humans

Seeing and Perceiving ◽

10.1163/187847612x646280 ◽

2012 ◽

Vol 25 (0) ◽

pp. 5 ◽

Cited By ~ 1

Author(s):

Anton L. Beer ◽

Tina Plank ◽

Evangelia-Regkina Symeonidou ◽

Georg Meyer ◽

Mark W. Greenlee

Keyword(s):

White Matter ◽

Functional Activity ◽

Occipital Lobe ◽

Object Perception ◽

Occipital Cortex ◽

Fiber Tracking ◽

Visual Object ◽

Body Movements ◽

Body Area ◽

Probabilistic Tracking

Previous functional magnetic resonance imaging (MRI) found various brain areas in the temporal and occipital lobe involved in integrating auditory and visual object information. Fiber tracking based on diffusion-weighted MRI suggested neuroanatomical connections between auditory cortex and sub-regions of the temporal and occipital lobe. However, the relationship between functional activity and white-matter tracks remained unclear. Here, we combined probabilistic tracking and functional MRI in order to reveal the structural connections related to auditory–visual object perception. Ten healthy people were examined by diffusion-weighted and functional MRI. During functional examinations they viewed either movies of lip or body movements, listened to corresponding sounds (phonological sounds or body action sounds), or a combination of both. We found that phonological sounds elicited stronger activity in the lateral superior temporal gyrus (STG) than body action sounds. Body movements elicited stronger activity in the lateral occipital cortex than lip movements. Functional activity in the phonological STG region and the lateral occipital body area were mutually modulated (sub-additive) by combined auditory–visual stimulation. Moreover, bimodal stimuli engaged a region in the posterior superior temporal sulcus (STS). Probabilistic tracking revealed white-matter tracks between the auditory cortex and sub-regions of the STS (anterior and posterior) and occipital cortex. The posterior STS region was also found to be relevant for auditory–visual object perception. The anterior STS region showed connections to the phonological STG area and to the lateral occipital body area. Our findings suggest that multisensory networks in the temporal lobe are best revealed by combining functional and structural measures.

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Possible Retrogenesis Observed with Fiber Tracking: An Anteroposterior Pattern of White Matter Disintegrity in Normal Aging and Alzheimer's Disease

Journal of Alzheimer s Disease ◽

10.3233/jad-2011-101788 ◽

2011 ◽

Vol 26 (1) ◽

pp. 47-58 ◽

Cited By ~ 19

Author(s):

Junling Gao ◽

Raymond Tak-Fai Cheung ◽

Tatia M.C. Lee ◽

Leung-Wing Chu ◽

Ying-Shing Chan ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

White Matter ◽

Fiber Tracking ◽

Normal Aging

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White matter fiber tracking directed by interpolating splines and a methodological framework for evaluation

Frontiers in Neuroinformatics ◽

10.3389/fninf.2013.00013 ◽

2013 ◽

Vol 7 ◽

Cited By ~ 1

Author(s):

Are Losnegård ◽

Arvid Lundervold ◽

Erlend Hodneland

Keyword(s):

White Matter ◽

Fiber Tracking ◽

Methodological Framework ◽

Interpolating Splines

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DWI Fiber Tracking with Functional MRI of White Matter

Lecture Notes in Computer Science - Artificial Intelligence and Security ◽

10.1007/978-3-030-24274-9_38 ◽

2019 ◽

pp. 425-433

Author(s):

Xiaofeng Dong ◽

Dan Xiao ◽

Zhipeng Yang

Keyword(s):

White Matter ◽

Functional Mri ◽

Fiber Tracking

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Fiber tracking of white matter integrity connecting the mediodorsal nucleus of the thalamus and the prefrontal cortex in schizophrenia: A diffusion tensor imaging study

European Psychiatry ◽

10.1016/j.eurpsy.2008.12.012 ◽

2009 ◽

Vol 24 (5) ◽

pp. 269-274 ◽

Cited By ~ 13

Author(s):

Shinsuke Kito ◽

Jiuk Jung ◽

Tetsuo Kobayashi ◽

Yoshihiko Koga

Keyword(s):

Prefrontal Cortex ◽

Standard Deviation ◽

White Matter ◽

Fractional Anisotropy ◽

Fiber Tracking ◽

Cross Sectional Area ◽

White Matter Integrity ◽

Sectional Area ◽

Cross Sectional ◽

The Cross

AbstractThe goal of this study was to detect abnormalities in white matter integrity connecting the mediodorsal nucleus of the thalamus and the prefrontal cortex using fiber-tracking technique. Diffusion tensor imaging was acquired in 20 patients with schizophrenia and 20 normal comparison subjects. Fiber tracking was performed on the anterior thalamic peduncle, and the tractography was used to determine the cross-sectional area, mean fractional anisotropy, and standard deviation of fractional anisotropy for every step separately in the right and left hemispheres. Compared with normal subjects, patients showed a significant reduction in the cross-sectional area of the left anterior thalamic peduncle. There were no significant differences for the mean fractional anisotropy bilaterally between the two groups, but significant differences for the standard deviation of fractional anisotropy in both hemispheres. Reduction in the cross-sectional area of the left anterior thalamic peduncle suggests the presence of the failure of left-hemisphere lateralization. In schizophrenic patients a significant increase of the standard deviation of fractional anisotropy raise the possibility that the inhomogeneity of white matter integrity, which is densely or sparsely distributed by site. These findings might provide further evidence for disruption of white matter integrity between the thalamus and the prefrontal cortex in schizophrenia.

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