Enzyme-conjugated gold nanoparticles for combined enzyme and photothermal therapy of colon cancer cells

Bacterial pigment undecylprodigiosin was conjugated to monodisperse gold nanoparticles, resulting in improved stability and cytotoxicity against colon cancer cells.

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Plasmonic photothermal therapy of colon cancer cells utilising gold nanoshells: an in vitro study

IET Nanobiotechnology ◽

10.1049/iet-nbt.2017.0144 ◽

2017 ◽

Vol 12 (2) ◽

pp. 196-200 ◽

Cited By ~ 2

Author(s):

Samira Rasouli Koohi ◽

Mohammad Ali Derakhshan ◽

Faramarz Faridani ◽

Samad Muhammad Nejad ◽

Saeid Amanpour ◽

...

Keyword(s):

Colon Cancer ◽

Cancer Cells ◽

Photothermal Therapy ◽

In Vitro Study ◽

Vitro Study ◽

Gold Nanoshells ◽

Colon Cancer Cells ◽

Plasmonic Photothermal Therapy

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Spiky Gold Nanoparticles for the Photothermal Eradication of Colon Cancer Cells

Nanomaterials ◽

10.3390/nano11061608 ◽

2021 ◽

Vol 11 (6) ◽

pp. 1608

Author(s):

Paolo Emidio Costantini ◽

Matteo Di Giosia ◽

Luca Ulfo ◽

Annapaola Petrosino ◽

Roberto Saporetti ◽

...

Keyword(s):

Colon Cancer ◽

Gold Nanoparticles ◽

Cancer Cells ◽

Rapid Onset ◽

Laser Source ◽

Colon Cancer Cells ◽

Onset Of Action ◽

Membrane Rupture ◽

Heating And Cooling ◽

Development Of Resistance

Colorectal cancer (CRC) is a widespread and lethal disease. Relapses of the disease and metastasis are very common in instances of CRC, so adjuvant therapies have a crucial role in its treatment. Systemic toxic effects and the development of resistance during therapy limit the long-term efficacy of existing adjuvant therapeutic approaches. Consequently, the search for alternative strategies is necessary. Photothermal therapy (PTT) represents an innovative treatment for cancer with great potential. Here, we synthesize branched gold nanoparticles (BGNPs) as attractive agents for the photothermal eradication of colon cancer cells. By controlling the NP growth process, large absorption in the first NIR biological window was obtained. The FBS dispersed BGNPs are stable in physiological-like environments and show an extremely efficient light-to-heat conversion capability when irradiated with an 808-nm laser. Sequential cycles of heating and cooling do not affect the BGNP stability. The uptake of BGNPs in colon cancer cells was confirmed using flow cytometry and confocal microscopy, exploiting their intrinsic optical properties. In dark conditions, BGNPs are fully biocompatible and do not compromise cell viability, while an almost complete eradication of colon cancer cells was observed upon incubation with BGNPs and irradiation with an 808-nm laser source. The PTT treatment is characterized by an extremely rapid onset of action that leads to cell membrane rupture by induced hyperthermia, which is the trigger that promotes cancer cell death.

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SN38 conjugated hyaluronic acid gold nanoparticles as a novel system against metastatic colon cancer cells

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2017.04.060 ◽

2017 ◽

Vol 526 (1-2) ◽

pp. 339-352 ◽

Cited By ~ 14

Author(s):

Hosniyeh Hosseinzadeh ◽

Fatemeh Atyabi ◽

Behrang Shiri Varnamkhasti ◽

Reza Hosseinzadeh ◽

Seyed Nasser Ostad ◽

...

Keyword(s):

Colon Cancer ◽

Gold Nanoparticles ◽

Hyaluronic Acid ◽

Cancer Cells ◽

Metastatic Colon Cancer ◽

Colon Cancer Cells

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Green and Synthetic Metallic Nanoparticles - Obtaining, Characterization and Biological Evaluation in Association with Lupeol

Revista de Chimie ◽

10.37358/rc.20.5.8137 ◽

2020 ◽

Vol 71 (5) ◽

pp. 299-304

Author(s):

Flavia Bociort ◽

Adelina Cheveresan ◽

Razvan Dragoi ◽

Alina Heghes ◽

Camelia Szuhanek ◽

...

Keyword(s):

Colon Cancer ◽

Gold Nanoparticles ◽

Cancer Cells ◽

Metallic Nanoparticles ◽

Chemical Characterization ◽

Biological Evaluation ◽

Colon Cancer Cells ◽

Lemon Balm ◽

Physico Chemical ◽

Average Size

The field of metal nanotechnology continues to draw the attention of researchers from different areas due to the outstanding properties of nanoparticles. The main aims of this research were to obtain and to study two types of gold nanoparticles; different obtaining pathways (the chemical synthesis and the biosynthesis based on an aqueous extract of lemon balm) were involved in this research. The chemically synthesized nanoparticles were loaded with lupeol. After a preliminary physico-chemical characterization, the compounds obtained were tested in order to evaluate the effects on the viability of colon cancer cells. The formulation of these new gold nanoparticles with average size between 38 and 82 nm, with a good stability against the tendency to form agglomerations according to the Zeta potential values, was confirmed by UV-Vis spectra; the particles containing lupeol have show the best activity against the colon cancer cells.

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