scholarly journals Spiky Gold Nanoparticles for the Photothermal Eradication of Colon Cancer Cells

Nanomaterials ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1608
Author(s):  
Paolo Emidio Costantini ◽  
Matteo Di Giosia ◽  
Luca Ulfo ◽  
Annapaola Petrosino ◽  
Roberto Saporetti ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Gold Nanoparticles ◽  
Cancer Cells ◽  
Rapid Onset ◽  
Laser Source ◽  
Colon Cancer Cells ◽  
Onset Of Action ◽  
Membrane Rupture ◽  
Heating And Cooling ◽  
Development Of Resistance

Colorectal cancer (CRC) is a widespread and lethal disease. Relapses of the disease and metastasis are very common in instances of CRC, so adjuvant therapies have a crucial role in its treatment. Systemic toxic effects and the development of resistance during therapy limit the long-term efficacy of existing adjuvant therapeutic approaches. Consequently, the search for alternative strategies is necessary. Photothermal therapy (PTT) represents an innovative treatment for cancer with great potential. Here, we synthesize branched gold nanoparticles (BGNPs) as attractive agents for the photothermal eradication of colon cancer cells. By controlling the NP growth process, large absorption in the first NIR biological window was obtained. The FBS dispersed BGNPs are stable in physiological-like environments and show an extremely efficient light-to-heat conversion capability when irradiated with an 808-nm laser. Sequential cycles of heating and cooling do not affect the BGNP stability. The uptake of BGNPs in colon cancer cells was confirmed using flow cytometry and confocal microscopy, exploiting their intrinsic optical properties. In dark conditions, BGNPs are fully biocompatible and do not compromise cell viability, while an almost complete eradication of colon cancer cells was observed upon incubation with BGNPs and irradiation with an 808-nm laser source. The PTT treatment is characterized by an extremely rapid onset of action that leads to cell membrane rupture by induced hyperthermia, which is the trigger that promotes cancer cell death.

Enzyme-conjugated gold nanoparticles for combined enzyme and photothermal therapy of colon cancer cells

2019 ◽  
Vol 572 ◽  
pp. 333-344 ◽  
Author(s):  
Mostafa Akbarzadeh Khiavi ◽  
Azam Safary ◽  
Ayuob Aghanejad ◽  
Jaleh Barar ◽  
Seyed Hossein Rasta ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Gold Nanoparticles ◽  
Cancer Cells ◽  
Photothermal Therapy ◽  
Colon Cancer Cells

Undecylprodigiosin conjugated monodisperse gold nanoparticles efficiently cause apoptosis in colon cancer cells in vitro

2014 ◽  
Vol 2 (21) ◽  
pp. 3271-3281 ◽  
Author(s):  
Jasmina Nikodinovic-Runic ◽  
Marija Mojic ◽  
Yijin Kang ◽  
Danijela Maksimovic-Ivanic ◽  
Sanja Mijatovic ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Gold Nanoparticles ◽  
Cancer Cells ◽  
Colon Cancer Cells ◽  
Bacterial Pigment ◽  
Improved Stability

Bacterial pigment undecylprodigiosin was conjugated to monodisperse gold nanoparticles, resulting in improved stability and cytotoxicity against colon cancer cells.

SN38 conjugated hyaluronic acid gold nanoparticles as a novel system against metastatic colon cancer cells

2017 ◽  
Vol 526 (1-2) ◽  
pp. 339-352 ◽  
Author(s):  
Hosniyeh Hosseinzadeh ◽  
Fatemeh Atyabi ◽  
Behrang Shiri Varnamkhasti ◽  
Reza Hosseinzadeh ◽  
Seyed Nasser Ostad ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Gold Nanoparticles ◽  
Hyaluronic Acid ◽  
Cancer Cells ◽  
Metastatic Colon Cancer ◽  
Colon Cancer Cells

scholarly journals Green and Synthetic Metallic Nanoparticles - Obtaining, Characterization and Biological Evaluation in Association with Lupeol

2020 ◽  
Vol 71 (5) ◽  
pp. 299-304
Author(s):  
Flavia Bociort ◽  
Adelina Cheveresan ◽  
Razvan Dragoi ◽  
Alina Heghes ◽  
Camelia Szuhanek ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Gold Nanoparticles ◽  
Cancer Cells ◽  
Metallic Nanoparticles ◽  
Chemical Characterization ◽  
Biological Evaluation ◽  
Colon Cancer Cells ◽  
Lemon Balm ◽  
Physico Chemical ◽  
Average Size

The field of metal nanotechnology continues to draw the attention of researchers from different areas due to the outstanding properties of nanoparticles. The main aims of this research were to obtain and to study two types of gold nanoparticles; different obtaining pathways (the chemical synthesis and the biosynthesis based on an aqueous extract of lemon balm) were involved in this research. The chemically synthesized nanoparticles were loaded with lupeol. After a preliminary physico-chemical characterization, the compounds obtained were tested in order to evaluate the effects on the viability of colon cancer cells. The formulation of these new gold nanoparticles with average size between 38 and 82 nm, with a good stability against the tendency to form agglomerations according to the Zeta potential values, was confirmed by UV-Vis spectra; the particles containing lupeol have show the best activity against the colon cancer cells.

Green synthesis of gold nanoparticles using brown algae Cystoseira baccata : Its activity in colon cancer cells

2017 ◽  
Vol 153 ◽  
pp. 190-198 ◽  
Author(s):  
N. González-Ballesteros ◽  
S. Prado-López ◽  
J.B. Rodríguez-González ◽  
M. Lastra ◽  
M.C. Rodríguez-Argüelles
Keyword(s):  
Colon Cancer ◽  
Gold Nanoparticles ◽  
Green Synthesis ◽  
Cancer Cells ◽  
Brown Algae ◽  
Colon Cancer Cells

scholarly journals The Sphingosine Kinase 2 Inhibitor ABC294640 Restores the Sensitivity of BRAFV600E Mutant Colon Cancer Cells to Vemurafenib by Reducing AKT-Mediated Expression of Nucleophosmin and Translationally-Controlled Tumour Protein

2021 ◽  
Vol 22 (19) ◽  
pp. 10767
Author(s):  
Petra Grbčić ◽  
Thomas O. Eichmann ◽  
Sandra Kraljević Pavelić ◽  
Mirela Sedić
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Sphingolipid Metabolism ◽  
Colon Cancer Cells ◽  
Expression Levels ◽  
Proliferative Effect ◽  
Development Of Resistance ◽  
Drug Concentrations ◽  
Braf Mutant ◽  
Resistant Cells

Vemurafenib (PLX4032), small-molecule inhibitor of mutated BRAFV600E protein, has emerged as a potent anti-cancer agent against metastatic melanoma harboring BRAFV600E mutation. Unfortunately, the effect of PLX4032 in the treatment of metastatic BRAF mutated colorectal cancer (CRC) is less potent due to high incidence of fast-developing chemoresistance. It has been demonstrated that sphingolipids are important mediators of chemoresistance to various therapies in colon cancer. In this study, we will explore the role of major regulators of sphingolipid metabolism and signaling in the development of resistance to vemurafenib in BRAF mutant colon cancer cells. The obtained data revealed significantly increased expression levels of activated sphingosine kinases (SphK1 and SphK2) in resistant cells concomitant with increased abundance of sphingosine-1-phosphate (S1P) and its precursor sphingosine, which was accompanied by increased expression levels of the enzymes regulating the ceramide salvage pathway, namely ceramide synthases 2 and 6 and acid ceramidase, especially after the exposure to vemurafenib. Pharmacological inhibition of SphK1/SphK2 activities or modulation of ceramide metabolism by exogenous C6-ceramide enhanced the anti-proliferative effect of PLX4032 in resistant RKO cells in a synergistic manner. It is important to note that the inhibition of SphK2 by ABC294640 proved effective at restoring the sensitivity of resistant cells to vemurafenib at the largest number of combinations of sub-toxic drug concentrations with minimal cytotoxicity. Furthermore, the obtained findings revealed that enhanced anti-proliferative, anti-migratory, anti-clonogenic and pro-apoptotic effects of a combination treatment with ABC294640 and PLX4032 relative to either drug alone were accompanied by the inhibition of S1P-regulated AKT activity and concomitant abrogation of AKT-mediated cellular levels of nucleophosmin and translationally-controlled tumour protein. Collectively, our study suggests the possibility of using the combination of ABC294640 and PLX4032 as a novel therapeutic approach to combat vemurafenib resistance in BRAF mutant colon cancer, which warrants additional preclinical validation studies.

Gold nanoparticles regulate tight junctions and improve cetuximab effect in colon cancer cells

Nanomedicine ◽  
2019 ◽  
Vol 14 (12) ◽  
pp. 1565-1578 ◽  
Author(s):  
Fernanda Leve ◽  
Daniella P Bonfim ◽  
Giselle Fontes ◽  
José A Morgado-Díaz
Keyword(s):  
Colon Cancer ◽  
Gold Nanoparticles ◽  
Cancer Cells ◽  
Tight Junctions ◽  
Colon Cancer Cells
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