scholarly journals Green and Synthetic Metallic Nanoparticles - Obtaining, Characterization and Biological Evaluation in Association with Lupeol

2020 ◽  
Vol 71 (5) ◽  
pp. 299-304
Author(s):  
Flavia Bociort ◽  
Adelina Cheveresan ◽  
Razvan Dragoi ◽  
Alina Heghes ◽  
Camelia Szuhanek ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Gold Nanoparticles ◽  
Cancer Cells ◽  
Metallic Nanoparticles ◽  
Chemical Characterization ◽  
Biological Evaluation ◽  
Colon Cancer Cells ◽  
Lemon Balm ◽  
Physico Chemical ◽  
Average Size

The field of metal nanotechnology continues to draw the attention of researchers from different areas due to the outstanding properties of nanoparticles. The main aims of this research were to obtain and to study two types of gold nanoparticles; different obtaining pathways (the chemical synthesis and the biosynthesis based on an aqueous extract of lemon balm) were involved in this research. The chemically synthesized nanoparticles were loaded with lupeol. After a preliminary physico-chemical characterization, the compounds obtained were tested in order to evaluate the effects on the viability of colon cancer cells. The formulation of these new gold nanoparticles with average size between 38 and 82 nm, with a good stability against the tendency to form agglomerations according to the Zeta potential values, was confirmed by UV-Vis spectra; the particles containing lupeol have show the best activity against the colon cancer cells.

Enzyme-conjugated gold nanoparticles for combined enzyme and photothermal therapy of colon cancer cells

2019 ◽  
Vol 572 ◽  
pp. 333-344 ◽  
Author(s):  
Mostafa Akbarzadeh Khiavi ◽  
Azam Safary ◽  
Ayuob Aghanejad ◽  
Jaleh Barar ◽  
Seyed Hossein Rasta ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Gold Nanoparticles ◽  
Cancer Cells ◽  
Photothermal Therapy ◽  
Colon Cancer Cells

scholarly journals Synthesis and biological evaluation of 6H-1-benzopyrano[4,3-b]quinolin-6-one derivatives as inhibitors of colon cancer cell growth

2015 ◽  
Vol 10 (3) ◽  
pp. 660
Author(s):  
Tie-Ling Li ◽  
Hai-Feng Guo ◽  
Fu-Juan Li ◽  
Zhi-Guo Sun ◽  
Heng-Chun Zhang
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Biological Evaluation ◽  
Colon Cancer Cell ◽  
Hek293 Cells ◽  
Colon Cancer Cells ◽  
Chromosomal Dna ◽  
Cancer Cell Growth ◽  
Hct 116

<p class="Abstract">A convenient synthesis of 6H-1-benzopyrano[4,3-b]quinolin-6-one derivatives was reported using 4-chloro-2-oxo-2H-chromene-3-carbaldehyde with different aromatic amines using silica sulfuric acid. The compounds were tested for their anticancer activity against colon (HCT-116 and S1-MI-80), prostate (PC3 and DU-145), breast (MCF-7 and MDAMB-231) cancer cells. These com-pounds showed more selectivity and potent cytotoxic activity against colon cancer cells. 3c was tested against five other colon cancer cell lines (HT-29, HCT-15, LS-180, LS-174, and LoVo), which had similar cytotoxicity and selectivity. 3c did not induce PXR-regulated ABCB1 or ABCG2 transporters. In fact, 3c induced cytotoxicity in HEK293 cells over expressing ABCB1 or ABCG2 to the same extent as in normal HEK293 cells. It was cytotoxic approximately 3- and 5-fold to resistant colon carcinoma S1-MI-80 cells. 3c also produced concentration-dependent changes in HCT-116 colon cancer cells, in mitochondrial membrane potential, leading to apoptosis, and sub-micromolar concentrations caused chromosomal DNA fragmentation. </p><p> </p>

Undecylprodigiosin conjugated monodisperse gold nanoparticles efficiently cause apoptosis in colon cancer cells in vitro

2014 ◽  
Vol 2 (21) ◽  
pp. 3271-3281 ◽  
Author(s):  
Jasmina Nikodinovic-Runic ◽  
Marija Mojic ◽  
Yijin Kang ◽  
Danijela Maksimovic-Ivanic ◽  
Sanja Mijatovic ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Gold Nanoparticles ◽  
Cancer Cells ◽  
Colon Cancer Cells ◽  
Bacterial Pigment ◽  
Improved Stability

Bacterial pigment undecylprodigiosin was conjugated to monodisperse gold nanoparticles, resulting in improved stability and cytotoxicity against colon cancer cells.

scholarly journals Spiky Gold Nanoparticles for the Photothermal Eradication of Colon Cancer Cells

Nanomaterials ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1608
Author(s):  
Paolo Emidio Costantini ◽  
Matteo Di Giosia ◽  
Luca Ulfo ◽  
Annapaola Petrosino ◽  
Roberto Saporetti ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Gold Nanoparticles ◽  
Cancer Cells ◽  
Rapid Onset ◽  
Laser Source ◽  
Colon Cancer Cells ◽  
Onset Of Action ◽  
Membrane Rupture ◽  
Heating And Cooling ◽  
Development Of Resistance

Colorectal cancer (CRC) is a widespread and lethal disease. Relapses of the disease and metastasis are very common in instances of CRC, so adjuvant therapies have a crucial role in its treatment. Systemic toxic effects and the development of resistance during therapy limit the long-term efficacy of existing adjuvant therapeutic approaches. Consequently, the search for alternative strategies is necessary. Photothermal therapy (PTT) represents an innovative treatment for cancer with great potential. Here, we synthesize branched gold nanoparticles (BGNPs) as attractive agents for the photothermal eradication of colon cancer cells. By controlling the NP growth process, large absorption in the first NIR biological window was obtained. The FBS dispersed BGNPs are stable in physiological-like environments and show an extremely efficient light-to-heat conversion capability when irradiated with an 808-nm laser. Sequential cycles of heating and cooling do not affect the BGNP stability. The uptake of BGNPs in colon cancer cells was confirmed using flow cytometry and confocal microscopy, exploiting their intrinsic optical properties. In dark conditions, BGNPs are fully biocompatible and do not compromise cell viability, while an almost complete eradication of colon cancer cells was observed upon incubation with BGNPs and irradiation with an 808-nm laser source. The PTT treatment is characterized by an extremely rapid onset of action that leads to cell membrane rupture by induced hyperthermia, which is the trigger that promotes cancer cell death.

SN38 conjugated hyaluronic acid gold nanoparticles as a novel system against metastatic colon cancer cells

2017 ◽  
Vol 526 (1-2) ◽  
pp. 339-352 ◽  
Author(s):  
Hosniyeh Hosseinzadeh ◽  
Fatemeh Atyabi ◽  
Behrang Shiri Varnamkhasti ◽  
Reza Hosseinzadeh ◽  
Seyed Nasser Ostad ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Gold Nanoparticles ◽  
Hyaluronic Acid ◽  
Cancer Cells ◽  
Metastatic Colon Cancer ◽  
Colon Cancer Cells

Green synthesis of gold nanoparticles using brown algae Cystoseira baccata : Its activity in colon cancer cells

2017 ◽  
Vol 153 ◽  
pp. 190-198 ◽  
Author(s):  
N. González-Ballesteros ◽  
S. Prado-López ◽  
J.B. Rodríguez-González ◽  
M. Lastra ◽  
M.C. Rodríguez-Argüelles
Keyword(s):  
Colon Cancer ◽  
Gold Nanoparticles ◽  
Green Synthesis ◽  
Cancer Cells ◽  
Brown Algae ◽  
Colon Cancer Cells

scholarly journals Enantioselective synthesis and biological evaluation of a-hydroxylated lactone lignans

2003 ◽  
Vol 75 (2-3) ◽  
pp. 273-278 ◽  
Author(s):  
M. Sefkow ◽  
M. Raschke ◽  
C. Steiner
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Biological Evaluation ◽  
Enantioselective Synthesis ◽  
Colon Cancer Cells ◽  
Efficient Synthesis ◽  
Enantiomerically Pure ◽  
Synthesis And Biological Evaluation

A short and efficient synthesis of enantiomerically pure α-hydroxylated lactone lignans starting from commercially available diisopropyl malate is presented. Stereoselective alkylation with various benzyl bromides and saponification yielded the corresponding succinic acids. Acetalization afforded the dioxolanones, which were stereoselectively alkylated. Reduction (and deprotection, where required) yielded the lactone lignans in up to 30 % overall yield. The inhibition of the proliferation of HT29 colon cancer cells was investigated. One lignane, bis-2,4,6 trimethylbenzyllactone lignan, was active (IC50 = 35 μM), whereas all other tested lignans were inactive within the investigated concentration range.

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