Development of PEG–PLA/PLGA microparticles for pulmonary drug delivery prepared by a novel emulsification technique assisted with amphiphilic block copolymers

2011 ◽  
Vol 87 (2) ◽  
pp. 433-438 ◽  
Author(s):  
Taku Takami ◽  
Yoshihiko Murakami
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Pulmonary Drug Delivery ◽  
Amphiphilic Block Copolymers ◽  
Plga Microparticles

scholarly journals Polymerisation-induced self-assembly (PISA) as a straightforward formulation strategy for stimuli-responsive drug delivery systems and biomaterials: recent advances

2021 ◽  
Vol 9 (1) ◽  
pp. 38-50
Author(s):  
Hien Phan ◽  
Vincenzo Taresco ◽  
Jacques Penelle ◽  
Benoit Couturaud
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Drug Release ◽  
Self Assembly ◽  
Drug Delivery Systems ◽  
Amphiphilic Block Copolymers ◽  
Stimuli Responsive ◽  
Site Specific ◽  
On Demand ◽  
Redox Agents

Stimuli-responsive amphiphilic block copolymers obtained by PISA have emerged as promising nanocarriers for enhancing site-specific and on-demand drug release in response to a range of stimuli such as pH, redox agents, light or temperature.

scholarly journals Photo-Responsive Polymersomes as Drug Delivery System for Potential Medical Applications

Molecules ◽  
2020 ◽  
Vol 25 (21) ◽  
pp. 5147
Author(s):  
Wanting Hou ◽  
Ruiqi Liu ◽  
Siwei Bi ◽  
Qian He ◽  
Haibo Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Drug Delivery System ◽  
Delivery System ◽  
Raft Polymerization ◽  
Amphiphilic Block Copolymers ◽  
Medical Applications ◽  
Drug Molecules ◽  
Reversible Addition ◽  
Raft Agent

Due to a strong retardation effect of o-nitrobenzyl ester on polymerization, it is still a great challenge to prepare amphiphilic block copolymers for polymersomes with a o-nitrobenzyl ester-based hydrophobic block. Herein, we present one such solution to prepare amphiphilic block copolymers with pure poly (o-nitrobenzyl acrylate) (PNBA) as the hydrophobic block and poly (N,N’-dimethylacrylamide) (PDMA) as the hydrophilic block using bulk reversible addition-fragmentation chain transfer (RAFT) polymerization of o-nitrobenzyl acrylate using a PDMA macro-RAFT agent. The developed amphiphilic block copolymers have a suitable hydrophobic/hydrophilic ratio and can self-assemble into photoresponsive polymersomes for co-loading hydrophobic and hydrophilic cargos into hydrophobic membranes and aqueous compartments of the polymersomes. The polymersomes demonstrate a clear photo-responsive characteristic. Exposure to light irradiation at 365 nm can trigger a photocleavage reaction of o-nitrobenzyl groups, which results in dissociation of the polymersomes with simultaneous co-release of hydrophilic and hydrophobic cargoes on demand. Therefore, these polymersomes have great potential as a smart drug delivery nanocarrier for controllable loading and releasing of hydrophilic and hydrophobic drug molecules. Moreover, taking advantage of the conditional releasing of hydrophilic and hydrophobic drugs, the drug delivery system has potential use in medical applications such as cancer therapy.

Development of highly porous large PLGA microparticles for pulmonary drug delivery

Biomaterials ◽  
2009 ◽  
Vol 30 (10) ◽  
pp. 1947-1953 ◽  
Author(s):  
Yan Yang ◽  
Nimisha Bajaj ◽  
Peisheng Xu ◽  
Kimberly Ohn ◽  
Michael D. Tsifansky ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Pulmonary Drug Delivery ◽  
Plga Microparticles ◽  
Highly Porous

Erratum: Amphiphilic Block Copolymers for Drug Delivery

2005 ◽  
Vol 94 (5) ◽  
pp. 1160 ◽  
Author(s):  
Monica L. Adams ◽  
Afsaneh Lavasanifar ◽  
Glen S. Kwon
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Amphiphilic Block Copolymers

Morphology Regulation in Redox Destructible Amphiphilic Block Copolymers and Impact on Intracellular Drug Delivery

2018 ◽  
Vol 18 (7) ◽  
pp. 1800057 ◽  
Author(s):  
Raju Bej ◽  
Jayita Sarkar ◽  
Debes Ray ◽  
Vinod K. Aswal ◽  
Suhrit Ghosh
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Amphiphilic Block Copolymers ◽  
Intracellular Drug Delivery
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