Pharmacokinetics, biodistribution, in vitro cytotoxicity and biocompatibility of Vitamin E TPGS coated trans resveratrol liposomes

2016 ◽  
Vol 145 ◽  
pp. 479-491 ◽  
Author(s):  
Mahalingam Rajamanickam Vijayakumar ◽  
Kiran Yellappa Vajanthri ◽  
Chelladurai Karthikeyan Balavigneswaran ◽  
Sanjeev Kumar Mahto ◽  
Nira Mishra ◽  
...  
Keyword(s):  
Vitamin E ◽  
In Vitro Cytotoxicity ◽  
Vitamin E Tpgs

scholarly journals Liquid crystalline systems containing Vitamin E TPGS for the controlled transdermal nicotine delivery

2016 ◽  
Vol 52 (1) ◽  
pp. 191-200 ◽  
Author(s):  
Lívia Neves Borgheti-Cardoso ◽  
Fabiana Testa Moura de Carvalho Vicentini ◽  
Tais Gratieri ◽  
Maria Vitória Lopes Badra Bentley
Keyword(s):  
Vitamin E ◽  
Liquid Crystalline ◽  
Visual Analysis ◽  
Skin Permeation ◽  
Skin Irritation ◽  
Cubic Phase ◽  
Nicotine Delivery ◽  
Vitamin E Tpgs ◽  
Transdermal Nicotine

ABSTRACT Transdermal nicotine patches have been used in smoking cessation therapy, suggested for the treatment of skin disorders with eosinophilic infiltration and have been found to improve attention performance in patients with Alzheimer's disease and age-associated memory impairment. However, skin irritation with extended patch use is still a problem. The aim of this work was to develop a simple to prepare liquid crystalline system containing vitamin E TPGS that would be able to control nicotine delivery and reduce irritation and sensitization problems. The liquid crystalline phases were macroscopically characterized by visual analysis and examined microscopically under a polarized light microscope. Topical and transdermal delivery of nicotine were investigated in vitro using porcine ear skin mounted on a Franz diffusion cell. Nicotine skin permeation from the developed cubic phase followed zero-order kinetics (r = 0.993) and was significantly enhanced after 12 h when compared to the control formulation (nicotine solution) (p < 0.05) (138.86 ± 20.44 and 64.91 ± 4.06 μg/cm2, respectively). Cubic phase was also able to target viable skin layers in comparison to control solution (8.18 ± 1.89 and 2.63 ± 2.51 μg/cm2, respectively). Further studies to evaluate skin sensitization and irritation are now necessary.

Antifungal efficacy of Itraconazole loaded PLGA-nanoparticles stabilized by vitamin-E TPGS: In vitro and ex vivo studies

2019 ◽  
Vol 161 ◽  
pp. 87-95 ◽  
Author(s):  
Adel A. Alhowyan ◽  
Mohammad A. Altamimi ◽  
Mohd Abul Kalam ◽  
Abdul Arif Khan ◽  
Mohamed Badran ◽  
...  
Keyword(s):  
Vitamin E ◽  
Ex Vivo ◽  
Plga Nanoparticles ◽  
Vitamin E Tpgs ◽  
Antifungal Efficacy

scholarly journals Garcinol loaded vitamin E TPGS emulsified PLGA nanoparticles: preparation, physicochemical characterization, in vitro and in vivo studies

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Raghuvir H. Gaonkar ◽  
Soumya Ganguly ◽  
Saikat Dewanjee ◽  
Samarendu Sinha ◽  
Amit Gupta ◽  
...  
Keyword(s):  
Vitamin E ◽  
Physicochemical Characterization ◽  
Plga Nanoparticles ◽  
In Vivo Studies ◽  
Vitamin E Tpgs
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