Folic acid and trastuzumab conjugated redox responsive random multiblock copolymeric nanocarriers for breast cancer therapy: In-vitro and in-vivo studies

Cholesterol-PEG1000-FA (folic acid) was synthesized as a stabilizer to encapsulate DTX, for the construction of a promising targeted delivery system for breast cancer therapy.

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Folic acid modified copper oxide nanoparticles for targeted delivery in in vitro and in vivo systems

RSC Advances ◽

10.1039/c5ra08110f ◽

2015 ◽

Vol 5 (83) ◽

pp. 68169-68178 ◽

Cited By ~ 26

Author(s):

Dipranjan Laha ◽

Arindam Pramanik ◽

Sourav Chattopadhyay ◽

Sandip kumar Dash ◽

Somenath Roy ◽

...

Keyword(s):

Breast Cancer ◽

Folic Acid ◽

Cancer Therapy ◽

Copper Oxide ◽

Targeted Delivery ◽

Copper Oxide Nanoparticles ◽

Oxide Nanoparticles ◽

Breast Cancer Therapy

Targeted delivery of copper oxide nanoparticles for breast cancer therapy.

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HER2 Kinase-Targeted Breast Cancer Therapy: Design, Synthesis, and In Vitro and In Vivo Evaluation of Novel Lapatinib Congeners as Selective and Potent HER2 Inhibitors with Favorable Metabolic Stability

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.0c01647 ◽

2020 ◽

Vol 63 (24) ◽

pp. 15906-15945

Author(s):

Tamer A. Elwaie ◽

Safinaz E. Abbas ◽

Enayat I. Aly ◽

Riham F. George ◽

Hamdy Ali ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Therapy ◽

Metabolic Stability ◽

Breast Cancer Therapy ◽

In Vivo Evaluation ◽

Design Synthesis ◽

Therapy Design

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Improving breast cancer therapy using doxorubicin loaded solid lipid nanoparticles: Synthesis of a novel arginine-glycine-aspartic tripeptide conjugated, pH sensitive lipid and evaluation of the nanomedicine in vitro and in vivo

Biomedicine & Pharmacotherapy ◽

10.1016/j.biopha.2019.109006 ◽

2019 ◽

Vol 116 ◽

pp. 109006 ◽

Cited By ~ 20

Author(s):

Gang Zheng ◽

Meizhu Zheng ◽

Ben Yang ◽

Hui Fu ◽

Yongqing Li

Keyword(s):

Breast Cancer ◽

Cancer Therapy ◽

Solid Lipid Nanoparticles ◽

Lipid Nanoparticles ◽

Ph Sensitive ◽

Breast Cancer Therapy ◽

Solid Lipid ◽

Nanoparticles Synthesis

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Hydrogel-Mediated DOX⋅HCl/PTX Delivery System for Breast Cancer Therapy

International Journal of Molecular Sciences ◽

10.3390/ijms20194671 ◽

2019 ◽

Vol 20 (19) ◽

pp. 4671

Author(s):

Hoon Hyun ◽

Young Yoo ◽

So Kim ◽

Hyun Ko ◽

Heung Chun ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Therapy ◽

Anticancer Effect ◽

Breast Cancer Therapy ◽

Glycol Chitosan ◽

Burst Period ◽

Delivery Approach ◽

Dual Drug

We used a hydrogel-mediated dual drug delivery approach, based on an injectable glycol chitosan (GC) hydrogel, doxorubicin hydrochloride (DOX⋅HCl), and a complex of beta-cyclodextrin (β-CD) and paclitaxel (PTX) (GDCP) for breast cancer therapy in vitro and in vivo. The hydrogel was swollen over 3 days and remained so thereafter. After an initial burst period of 7 hours, the two drugs were released in a sustained manner for 7 days. The in vitro cell viability test showed that GDCP had a better anticancer effect than well plate and DOX⋅HCl/PTX (DP). In addition, the in vivo tests, which evaluated the anticancer effect, systemic toxicity, and histology, proved the feasibility of GDCP as a clinical therapy for breast cancer.

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Biodegradable polymeric micelles coencapsulating paclitaxel and honokiol: a strategy for breast cancer therapy in vitro and in vivo

International Journal of Nanomedicine ◽

10.2147/ijn.s124843 ◽

2017 ◽

Vol Volume 12 ◽

pp. 1499-1514 ◽

Cited By ~ 14

Author(s):

Ning Wang ◽

Zhihan Wang ◽

Shihong Nie ◽

Linjiang Song ◽

Tao He ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Therapy ◽

Polymeric Micelles ◽

Breast Cancer Therapy

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Stimuli-responsive Drug Delivery Nanocarriers in the Treatment of Breast Cancer

Current Medicinal Chemistry ◽

10.2174/0929867325666181009120610 ◽

2020 ◽

Vol 27 (15) ◽

pp. 2494-2513 ◽

Cited By ~ 2

Author(s):

João A. Oshiro-Júnior ◽

Camila Rodero ◽

Gilmar Hanck-Silva ◽

Mariana R. Sato ◽

Renata Carolina Alves ◽

...

Keyword(s):

Breast Cancer ◽

Drug Delivery ◽

Cancer Therapy ◽

Near Infrared ◽

Stimuli Responsive ◽

Breast Cancer Therapy ◽

Physical Stimuli ◽

Pharmaceutical Properties

Stimuli-responsive drug-delivery nanocarriers (DDNs) have been increasingly reported in the literature as an alternative for breast cancer therapy. Stimuli-responsive DDNs are developed with materials that present a drastic change in response to intrinsic/chemical stimuli (pH, redox and enzyme) and extrinsic/physical stimuli (ultrasound, Near-infrared (NIR) light, magnetic field and electric current). In addition, they can be developed using different strategies, such as functionalization with signaling molecules, leading to several advantages, such as (a) improved pharmaceutical properties of liposoluble drugs, (b) selectivity with the tumor tissue decreasing systemic toxic effects, (c) controlled release upon different stimuli, which are all fundamental to improving the therapeutic effectiveness of breast cancer treatment. Therefore, this review summarizes the use of stimuli-responsive DDNs in the treatment of breast cancer. We have divided the discussions into intrinsic and extrinsic stimuli and have separately detailed them regarding their definitions and applications. Finally, we aim to address the ability of these stimuli-responsive DDNs to control the drug release in vitro and the influence on breast cancer therapy, evaluated in vivo in breast cancer models.

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