Hydrogel-Mediated DOX⋅HCl/PTX Delivery System for Breast Cancer Therapy
Keyword(s):
We used a hydrogel-mediated dual drug delivery approach, based on an injectable glycol chitosan (GC) hydrogel, doxorubicin hydrochloride (DOX⋅HCl), and a complex of beta-cyclodextrin (β-CD) and paclitaxel (PTX) (GDCP) for breast cancer therapy in vitro and in vivo. The hydrogel was swollen over 3 days and remained so thereafter. After an initial burst period of 7 hours, the two drugs were released in a sustained manner for 7 days. The in vitro cell viability test showed that GDCP had a better anticancer effect than well plate and DOX⋅HCl/PTX (DP). In addition, the in vivo tests, which evaluated the anticancer effect, systemic toxicity, and histology, proved the feasibility of GDCP as a clinical therapy for breast cancer.
2020 ◽
Vol 63
(24)
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pp. 15906-15945
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2019 ◽
Vol 116
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pp. 109006
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2017 ◽
Vol 149
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pp. 369-378
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2017 ◽
Vol Volume 12
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pp. 1499-1514
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2020 ◽
Vol 27
(15)
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pp. 2494-2513
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2015 ◽
Vol 3
(22)
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pp. 4514-4523
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2021 ◽
Vol 203
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pp. 111760
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