pH-tunable nanoparticles composed of copolymers of lactide and allyl-glycidyl ether with various functionalities for the efficient delivery of anti-cancer drugs

2021 ◽  
Vol 204 ◽  
pp. 111801
Author(s):  
B. Kost ◽  
W. Gonciarz ◽  
A. Krupa ◽  
M. Socka ◽  
M. Rogala ◽  
...  
Keyword(s):  
Glycidyl Ether ◽  
Cancer Drugs ◽  
Efficient Delivery ◽  
Anti Cancer ◽  
Allyl Glycidyl Ether

Cellulose-graft-poly(l-lactic acid) nanoparticles for efficient delivery of anti-cancer drugs

2014 ◽  
Vol 2 (39) ◽  
pp. 6749-6757 ◽  
Author(s):  
Lin Dai ◽  
Tingyuan Yang ◽  
Jing He ◽  
Lihong Deng ◽  
Jing Liu ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Betulinic Acid ◽  
Cancer Drugs ◽  
Antitumor Activities ◽  
Efficient Delivery ◽  
Anti Cancer ◽  
Model Drug

BA-loaded cellulose-graft-poly(l-lactic acid) nanoparticles were fabricated by employing cellulose and poly(l-lactic acid) as materials and betulinic acid as a model drug. The nanoparticles have appropriate size and excellent antitumor activities.

Penetration and drug delivery of albumin nanoparticles into pancreatic multicellular tumor spheroids

2017 ◽  
Vol 5 (48) ◽  
pp. 9591-9599 ◽  
Author(s):  
Hongxu Lu ◽  
Lubna Noorani ◽  
Yanyan Jiang ◽  
Alice W. Du ◽  
Martina H. Stenzel
Keyword(s):  
Drug Delivery ◽  
Multicellular Tumor Spheroids ◽  
Cancer Drugs ◽  
Tumor Spheroids ◽  
Albumin Nanoparticles ◽  
Efficient Delivery ◽  
Anti Cancer

Albumin-based nanoparticles have been exploited as a useful carrier for the efficient delivery of anti-cancer drugs.

A Case of Malignant Melanoma Treated with a Combination of Anti-Cancer Drugs and Biological Response Modifiers.

1993 ◽  
Vol 55 (1) ◽  
pp. 43-46
Author(s):  
Jun YOSHIDA ◽  
Juichiro NAKAYAMA ◽  
Nobuyuki SHIMIZU ◽  
Shonosuke NAGAE ◽  
Yoshiaki HORI
Keyword(s):  
Malignant Melanoma ◽  
Biological Response ◽  
Biological Response Modifiers ◽  
Cancer Drugs ◽  
Anti Cancer

Current Scenario in Structure and Ligand-Based Drug Design on Anti-colon Cancer Drugs

2019 ◽  
Vol 24 (32) ◽  
pp. 3829-3841 ◽  
Author(s):  
Lakshmanan Loganathan ◽  
Karthikeyan Muthusamy
Keyword(s):  
Drug Discovery ◽  
Drug Design ◽  
Anticancer Agent ◽  
Computational Power ◽  
Cancer Drugs ◽  
Recent Advances ◽  
Anti Cancer ◽  
Drug Designing ◽  
Current Scenario ◽  
Molecular Modeling Studies

Worldwide, colorectal cancer takes up the third position in commonly detected cancer and fourth in cancer mortality. Recent progress in molecular modeling studies has led to significant success in drug discovery using structure and ligand-based methods. This study highlights aspects of the anticancer drug design. The structure and ligand-based drug design are discussed to investigate the molecular and quantum mechanics in anti-cancer drugs. Recent advances in anticancer agent identification driven by structural and molecular insights are presented. As a result, the recent advances in the field and the current scenario in drug designing of cancer drugs are discussed. This review provides information on how cancer drugs were formulated and identified using computational power by the drug discovery society.

Fanconi Anemia DNA Repair Pathway as a New Mechanism to Exploit Cancer Drug Resistance

2020 ◽  
Vol 20 (9) ◽  
pp. 779-787
Author(s):  
Kajal Ghosal ◽  
Christian Agatemor ◽  
Richard I. Han ◽  
Amy T. Ku ◽  
Sabu Thomas ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Dna Repair ◽  
Fanconi Anemia ◽  
Cancer Drug ◽  
Drug Resistant ◽  
Cancer Drugs ◽  
Repair Pathway ◽  
Cancer Drug Resistance ◽  
Anti Cancer ◽  
Cancerous Cells

Chemotherapy employs anti-cancer drugs to stop the growth of cancerous cells, but one common obstacle to the success is the development of chemoresistance, which leads to failure of the previously effective anti-cancer drugs. Resistance arises from different mechanistic pathways, and in this critical review, we focus on the Fanconi Anemia (FA) pathway in chemoresistance. This pathway has yet to be intensively researched by mainstream cancer researchers. This review aims to inspire a new thrust toward the contribution of the FA pathway to drug resistance in cancer. We believe an indepth understanding of this pathway will open new frontiers to effectively treat drug-resistant cancer.

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