scholarly journals Experimental studies on the three-dimensional effects of opposed-flow flame spread over thin solid materials

2011 ◽  
Vol 158 (6) ◽  
pp. 1193-1200 ◽  
Author(s):  
Xia Zhang ◽  
Yong Yu
Keyword(s):  
Flame Spread ◽  
Experimental Studies ◽  
Three Dimensional ◽  
Solid Materials ◽  
Dimensional Effects ◽  
Opposed Flow

scholarly journals Extracting maximal objects from three-dimensional solid materials

2021 ◽  
pp. 105290
Author(s):  
Everton Fernandes Silva ◽  
Hatice Çalık ◽  
Wim Vancroonenburg ◽  
Aline Aparecida Souza Leao ◽  
Tony Wauters
Keyword(s):  
Three Dimensional ◽  
Solid Materials

scholarly journals Targeting hepatocyte growth factor in epithelial–stromal interactions in an in vitro experimental model of human periodontitis

Odontology ◽  
2021 ◽  
Author(s):  
Yoko Yamaguchi ◽  
Akira Saito ◽  
Masafumi Horie ◽  
Akira Aoki ◽  
Patrick Micke ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Experimental Studies ◽  
Three Dimensional ◽  
Collagen Gel ◽  
Neutralizing Antibody ◽  
Chronic Inflammatory Disease ◽  
Collagen Degradation ◽  
Hepatocyte Growth

AbstractPeriodontitis is a chronic inflammatory disease leading to progressive connective tissue degradation and loss of the tooth-supporting bone. Clinical and experimental studies suggest that hepatocyte growth factor (HGF) is involved in the dysregulated fibroblast–epithelial cell interactions in periodontitis. The aim of this study was to explore effects of HGF to impact fibroblast-induced collagen degradation. A patient-derived experimental cell culture model of periodontitis was applied. Primary human epithelial cells and fibroblasts isolated from periodontitis-affected gingiva were co-cultured in a three-dimensional collagen gel. The effects of HGF neutralizing antibody on collagen gel degradation were tested and transcriptome analyses were performed. HGF neutralizing antibody attenuated collagen degradation and elicited expression changes of genes related to extracellular matrix (ECM) and cell adhesion, indicating that HGF signaling inhibition leads to extensive impact on cell–cell and cell–ECM interactions. Our study highlights a potential role of HGF in periodontitis. Antagonizing HGF signaling by a neutralizing antibody may represent a novel approach for periodontitis treatment.

scholarly journals Numerical and Experimental Studies on a Three-Dimensional Numerical Wave Tank

IEEE Access ◽  
2018 ◽  
Vol 6 ◽  
pp. 6585-6593 ◽  
Author(s):  
Xiaojie Tian ◽  
Qingyang Wang ◽  
Guijie Liu ◽  
Wei Deng ◽  
Zhiming Gao
Keyword(s):  
Experimental Studies ◽  
Three Dimensional ◽  
Numerical Wave Tank ◽  
Wave Tank ◽  
Numerical Wave

Numerical Modeling of Tube Hydropiercing Using Phenomenological and Micro-Mechanical Damage Criteria

2013 ◽  
Vol 549 ◽  
pp. 172-179 ◽  
Author(s):  
Amir Hassannejadasl ◽  
Daniel E. Green
Keyword(s):  
Experimental Studies ◽  
Three Dimensional ◽  
Equivalent Plastic Strain ◽  
Mechanical Damage ◽  
High Strength ◽  
Dimensional Finite Element ◽  
Steel Dp600 ◽  
Three Dimensional Finite Element ◽  
Jc Model ◽  
Damage Criteria

Hydropiercing is an efficient way of piercing holes in mass produced hydroformed parts with complex geometries. By driving piercing punches radially into a hydroformed and fully pressurized tube, holes will be pierced and extruded into the tube-wall. Recent experimental studies have shown that the formability of advanced high strength steel (AHSS) tubes can be increased with the application of internal pressure. In this study, three-dimensional finite element simulations of a tube hydropiercing process of a dual phase steel (DP600) were performed in LS-DYNA, using phenomenological, micromechanical and combined damage criteria. Damage was included in the numerical analysis by applying constant equivalent plastic strain (CEPS), the Gurson-Tvergaard-Needleman (GTN), and the Extended GTN (GTN+JC) model. In order to calibrate the parameters in each model, a specialized hole-piercing fixture was designed and piercing tests were carried out on non-pressurized tube specimens. Of the various ductile fracture criteria, the results predicted with the GTN+JC model, such as the punch load-displacement, the roll-over depth, and the quality of the clearance zone correlated the best with the experimental data.

Fracture Mechanics of Thin Plates and Shells Under Combined Membrane, Bending, and Twisting Loads

2005 ◽  
Vol 58 (1) ◽  
pp. 37-48 ◽  
Author(s):  
Alan T. Zehnder ◽  
Mark J. Viz
Keyword(s):  
Fracture Mechanics ◽  
Plate Theory ◽  
Experimental Studies ◽  
Three Dimensional ◽  
Crack Tip ◽  
Thin Plates ◽  
Element Analysis ◽  
Crack Tip Fields ◽  
Plates And Shells ◽  
Membrane Bending

The fracture mechanics of plates and shells under membrane, bending, twisting, and shearing loads are reviewed, starting with the crack tip fields for plane stress, Kirchhoff, and Reissner theories. The energy release rate for each of these theories is calculated and is used to determine the relation between the Kirchhoff and Reissner theories for thin plates. For thicker plates, this relationship is explored using three-dimensional finite element analysis. The validity of the application of two-dimensional (plate theory) solutions to actual three-dimensional objects is analyzed and discussed. Crack tip fields in plates undergoing large deflection are analyzed using von Ka´rma´n theory. Solutions for cracked shells are discussed as well. A number of computational methods for determining stress intensity factors in plates and shells are discussed. Applications of these computational approaches to aircraft structures are examined. The relatively few experimental studies of fracture in plates under bending and twisting loads are also reviewed. There are 101 references cited in this article.

Noninvasive three-dimensional electrocardiographic imaging of ventricular activation sequence

2005 ◽  
Vol 289 (6) ◽  
pp. H2724-H2732 ◽  
Author(s):  
Xin Zhang ◽  
Indiresha Ramachandra ◽  
Zhongming Liu ◽  
Basharat Muneer ◽  
Steven M. Pogwizd ◽  
...  
Keyword(s):  
Surface Potential ◽  
Body Surface ◽  
Cardiac Arrhythmias ◽  
Experimental Studies ◽  
Three Dimensional ◽  
Electrocardiographic Imaging ◽  
Ventricular Activation ◽  
Body Surface Potential ◽  
Life Threatening ◽  
Activation Sequence

Imaging the myocardial activation sequence is critical for improved diagnosis and treatment of life-threatening cardiac arrhythmias. It is desirable to reveal the underlying cardiac electrical activity throughout the three-dimensional (3-D) myocardium (rather than just the endocardial or epicardial surface) from noninvasive body surface potential measurements. A new 3-D electrocardiographic imaging technique (3-DEIT) based on the boundary element method (BEM) and multiobjective nonlinear optimization has been applied to reconstruct the cardiac activation sequences from body surface potential maps. Ultrafast computerized tomography scanning was performed for subsequent construction of the torso and heart models. Experimental studies were then conducted, during left and right ventricular pacing, in which noninvasive assessment of ventricular activation sequence by means of 3-DEIT was performed simultaneously with 3-D intracardiac mapping (up to 200 intramural sites) using specially designed plunge-needle electrodes in closed-chest rabbits. Estimated activation sequences from 3-DEIT were in good agreement with those constructed from simultaneously recorded intracardiac electrograms in the same animals. Averaged over 100 paced beats (from a total of 10 pacing sites), total activation times were comparable (53.3 ± 8.1 vs. 49.8 ± 5.2 ms), the localization error of site of initiation of activation was 5.73 ± 1.77 mm, and the relative error between the estimated and measured activation sequences was 0.32 ± 0.06. The present experimental results demonstrate that the 3-D paced ventricular activation sequence can be reconstructed by using noninvasive multisite body surface electrocardiographic measurements and imaging of heart-torso geometry. This new 3-D electrocardiographic imaging modality has the potential to guide catheter-based ablative interventions for the treatment of life-threatening cardiac arrhythmias.

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