scholarly journals Evolution of synapses and neurotransmitter systems: The divide-and-conquer model for early neural cell-type evolution

2021 ◽  
Vol 71 ◽  
pp. 127-138
Author(s):  
Pawel Burkhardt ◽  
Gáspár Jékely
Keyword(s):  
Neural Cell ◽  
Divide And Conquer ◽  
Cell Type ◽  
Neurotransmitter Systems

scholarly journals Structural Basis for Partial Redundancy in a Class of Transcription Factors, the LIM Homeodomain Proteins, in Neural Cell Type Specification

2011 ◽  
Vol 286 (50) ◽  
pp. 42971-42980 ◽  
Author(s):  
Morgan S. Gadd ◽  
Mugdha Bhati ◽  
Cy M. Jeffries ◽  
David B. Langley ◽  
Jill Trewhella ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Neural Cell ◽  
Structural Basis ◽  
Cell Type ◽  
Homeodomain Proteins ◽  
Partial Redundancy ◽  
Type Specification ◽  
Lim Homeodomain

scholarly journals Evolution of Synapses and Neurotransmitter Systems: The Divide-and-Conquer Model for Early Neural Cell-Type Evolution

2021 ◽  
Author(s):  
Pawel Burkhardt ◽  
Gáspár Jékely
Keyword(s):  
The Body ◽  
Divide And Conquer ◽  
Cambrian Explosion ◽  
Neuron Type ◽  
Cell Type ◽  
Sequencing Data ◽  
Single Cell Sequencing ◽  
Neuronal Genes ◽  
Voltage Gated Channels ◽  
Presynaptic Proteins

Nervous systems evolved around 560 million years ago to coordinate and empower animal bodies. Ctenophores – one of the earliest-branching lineages – are thought to share few neuronal genes with bilaterians and may have evolved neurons convergently. Here we review our current understanding of the evolution of neuronal molecules in non-bilaterians. We also reanalyse single-cell sequencing data in light of new cell-cluster identities from a ctenophore and uncover evidence supporting the homology of one ctenophore neuron-type with neurons in Bilateria. The specific coexpression of the presynaptic proteins Unc13 and RIM with voltage-gated channels, neuropeptides and homeobox genes pinpoint a spiking sensory-peptidergic cell in the ctenophore mouth. Similar Unc13-RIM neurons may have been present in the first eumetazoans to rise to dominance only in stem Bilateria. We hypothesize that the Unc13-RIM lineage ancestrally innervated the mouth and conquered other parts of the body with the rise of macrophagy and predation during the Cambrian explosion.

scholarly journals Neural Cell Type-Specific Expression of QKI Proteins Is Altered inquakingviableMutant Mice

1996 ◽  
Vol 16 (24) ◽  
pp. 7941-7949 ◽  
Author(s):  
Rebecca J. Hardy ◽  
Carrie L. Loushin ◽  
Victor L. Friedrich Jr. ◽  
Qi Chen ◽  
Thomas A. Ebersole ◽  
...  
Keyword(s):  
Neural Cell ◽  
Cell Type ◽  
Specific Expression ◽  
Cell Type Specific Expression ◽  
Cell Type Specific

scholarly journals Comprehensive Expression Analyses of Neural Cell-Type-Specific miRNAs Identify New Determinants of the Specification and Maintenance of Neuronal Phenotypes

2013 ◽  
Vol 33 (12) ◽  
pp. 5127-5137 ◽  
Author(s):  
A. Jovicic ◽  
R. Roshan ◽  
N. Moisoi ◽  
S. Pradervand ◽  
R. Moser ◽  
...  
Keyword(s):  
Neural Cell ◽  
Cell Type ◽  
Cell Type Specific

A Neural Cell-Type-Specific Expression System Using Recombinant Adenovirus Vectors

1996 ◽  
Vol 7 (2) ◽  
pp. 149-158 ◽  
Author(s):  
Mitsuhiro Hashimoto ◽  
Jun Aruga ◽  
Yasuhiko Hosoya ◽  
Yumi Kanegae ◽  
Izumu Saito ◽  
...  
Keyword(s):  
Recombinant Adenovirus ◽  
Expression System ◽  
Neural Cell ◽  
Cell Type ◽  
Specific Expression ◽  
Cell Type Specific Expression ◽  
Cell Type Specific ◽  
Adenovirus Vectors

Identification of IL-17A-derived neural cell type and dynamic changes of IL-17A in serum/CSF of mice with ischemic stroke

2017 ◽  
Vol 39 (6) ◽  
pp. 552-558 ◽  
Author(s):  
Shujuan Li ◽  
Qingqing Dai ◽  
Jinling Yu ◽  
Ting Liu ◽  
Shuiqiao Liu ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Neural Cell ◽  
Cell Type ◽  
Dynamic Changes
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