Effects of redispersible polymer powders on the structural build-up of 3D printing cement paste with and without hydroxypropyl methylcellulose

The 3D printing of concrete has now entered a new era and a transformation of the construction sector is expected to reshape fabrication with concrete. This work focuses on the selective paste intrusion method, which consists of bonding dry particles of aggregate with a cement paste. This innovative technique could lead to the production of very precise component for specific applications. The main obstacle to tackle in order to reach a high shape accuracy of high mechanical performances of 3D printing elements by selectively activating the material is the control of the distribution of the cement paste through the particle bed. With the aim to better understand the path followed by the solution as it penetrates a cut-section of the granular packing, two-dimensional numerical modeling is carried out using Comsol software. A phase-field method combined with a continuous visco-plastic model has been used to study the influence of the average grain diameter, the contact angle, and the rheological properties of cement pastes on the penetration depth. We compare the numerical modeling results to existing experimental results from 3D experiments and a one-dimensional analytical model. We then highlight that the proposed numerical approach is reliable to predict the final penetration of the cement pastes.

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3D printing of extended-release tablets of theophylline using hydroxypropyl methylcellulose (HPMC) hydrogels

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2020.119983 ◽

2020 ◽

Vol 591 ◽

pp. 119983

Author(s):

Yiliang Cheng ◽

Hantang Qin ◽

Nuria C. Acevedo ◽

Xuepeng Jiang ◽

Xiaolei Shi

Keyword(s):

3D Printing ◽

Extended Release ◽

Hydroxypropyl Methylcellulose

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3D Printing Geometric Scaffold Design Variation of Injectable Bone Substitutes (IBS) Pa

Indonesian Applied Physics Letters ◽

10.20473/iapl.v1i2.23447 ◽

2020 ◽

Vol 1 (2) ◽

pp. 55

Author(s):

Dyah Hikmawati ◽

Sarda Nugraheni ◽

Aminatun Aminatun

Keyword(s):

Drug Delivery ◽

Compressive Strength ◽

3D Printing ◽

Hydroxypropyl Methylcellulose ◽

Bone Substitutes ◽

Fused Deposition Modelling ◽

Scaffold Design ◽

Technology Application ◽

Fused Deposition ◽

Before And After

3D printing technology application in tissue engineering could be provided by designing geometrical scaffold architecture which also functionates as drug delivery. For drug delivery scaffold on bone tuberculosis, the cell pore of the geometric design was filled with Injectable Bone Substitutes (IBS) which had streptomycin as anti-tuberculosis. In this study, scaffolds were synthesized in three cells geometric filled by Injectable Bone Substitutes (IBS), Hexahedron, Truccated Hexahedron, and Rhombicuboctahedron, which had 2.5 mm x 2.5 mm x 2.5 mm size dimension and 0.8 mm strut. The final design was printed in 3D with polylactic acid (PLA) filament using the FDM process (Fused Deposition Modelling). The composition of IBS paste was a mixture of hydroxyapatite (HA) and gelatine (GEL) 20% w/v with a ratio of 60:40, streptomycin 10 wt% and hydroxypropyl methylcellulose (HPMC) 4% w/v. It was then characterized using Fourier-transform infrared spectroscopy (FTIR). Scaffold–paste characterization was included pore size test of 3D printing result before and after injected using Scanning Electron Microscope SEM, porosity test, and compressive strength test. The result showed that the pore of scaffold design was 1379 µm and after injected with IBS paste, the pore leaving 231.04 µm of size. The scaffold with IBS paste porosity test showed ranges between 40,78-70,04% while the compressive strength of before and after injected ranges between 1,110-634 MPa and 2,217-6,971 MPa respectively. From the test results, the scaffold 3D printing with IBS paste in this study had suitable physical characteristics to be applicated on cancellous bones which were infected by tuberculosis.

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Fabrication of Muco-Adhesive Oral Films by the 3D Printing of Hydroxypropyl Methylcellulose-Based Catechin-Loaded Formulations

Biological and Pharmaceutical Bulletin ◽

10.1248/bpb.b19-00481 ◽

2019 ◽

Vol 42 (11) ◽

pp. 1898-1905 ◽

Cited By ~ 4

Author(s):

Tatsuaki Tagami ◽

Natsumi Yoshimura ◽

Eiichi Goto ◽

Takehiro Noda ◽

Tetsuya Ozeki

Keyword(s):

3D Printing ◽

Hydroxypropyl Methylcellulose ◽

Oral Films

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A Feasibility Study on HPMC-Improved Sulphoaluminate Cement for 3D Printing

Materials ◽

10.3390/ma11122415 ◽

2018 ◽

Vol 11 (12) ◽

pp. 2415 ◽

Cited By ~ 8

Author(s):

Zhu Ding ◽

Xiaodong Wang ◽

Jay Sanjayan ◽

Patrick Zou ◽

Zhi-Kun Ding

Keyword(s):

Compressive Strength ◽

3D Printing ◽

Feasibility Study ◽

Setting Time ◽

Hydroxypropyl Methylcellulose ◽

Hydration Heat ◽

Heat Setting ◽

Sulphoaluminate Cement ◽

Final Setting Time ◽

Experimental Parameters

A novel 3D printing material based on hydroxypropyl methylcellulose (HPMC)—improved sulphoaluminate cement (SAC) for rapid 3D construction printing application is reported. The hydration heat, setting time, fluidity of paste and mortar, shape retainability, and compressive strength of extruded SAC mortar were investigated. HPMC dosage, water-to-cement (W/C) ratio, and sand-to-cement (S/C) ratio were studied as the experimental parameters. Hydration heat results reveal HPMC could delay the hydration of SAC. The initial and final setting time measured using Vicat needle would be shortened in the case of W/C ratio of 0.3 and 0.35 with HPMC dosage from 0.5% to 1.5%, W/C ratio of 0.40 with HPMC dosage of 0.5%, 0.75%, and 1.5%, and W/C ratio of 0.45 with HPMC dosage of 0.45, or be extended in the case of W/C ratio of 0.4 with HPMC dosage of 1.0% and W/C ratio of 0.45 with HPMC dosage from 0.75% to 1.5%. Fluidity measurement shows HPMC significantly improves the shape retainability. Furthermore, the addition of HPMC remarkably increased the compressive strength of extruded mortar. The results showed that HPMC could be used to prepare 3D printing SAC having satisfactory shape retainability, setting time and compressive strength.

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Hydroxypropyl Methylcellulose E15: A Hydrophilic Polymer for Fabrication of Orodispersible Film Using Syringe Extrusion 3D Printer

Polymers ◽

10.3390/polym12112666 ◽

2020 ◽

Vol 12 (11) ◽

pp. 2666

Author(s):

Pattaraporn Panraksa ◽

Suruk Udomsom ◽

Pornchai Rachtanapun ◽

Chuda Chittasupho ◽

Warintorn Ruksiriwanich ◽

...

Keyword(s):

Mechanical Properties ◽

3D Printing ◽

Hydroxypropyl Methylcellulose ◽

Therapeutic Index ◽

Pharmaceutical Products ◽

Content Uniformity ◽

3D Printer ◽

Disintegration Time ◽

Drug Content

Extrusion-based 3D printing technology is a relatively new technique that has a potential for fabricating pharmaceutical products in various dosage forms. It offers many advantages over conventional manufacturing methods, including more accurate drug dosing, which is especially important for the drugs that require exact tailoring (e.g., narrow therapeutic index drugs). In this work, we have successfully fabricated phenytoin-loaded orodispersible films (ODFs) through a syringe extrusion 3D printing technique. Two different grades of hydroxypropyl methylcellulose (HPMC E5 and HPMC E15) were used as the film-forming polymers, and glycerin and propylene glycol were used as plasticizers. The 3D-printed ODFs were physicochemically characterized and evaluated for their mechanical properties and in vitro disintegration time. Then, the optimum printed ODFs showing good mechanical properties and the fastest disintegration time were selected to evaluate their drug content and dissolution profiles. The results showed that phenytoin-loaded E15 ODFs demonstrated superior properties when compared to E5 films. It demonstrated a fast disintegration time in less than 5 s and rapidly dissolved and reached up to 80% of drug release within 10 min. In addition, it also exhibited drug content uniformity within United States Pharmacopeia (USP) acceptable range and exhibited good mechanical properties and flexibility with low puncture strength, low Young’s modulus and high elongation, which allows ease of handling and application. Furthermore, the HPMC E15 printing dispersions with suitable concentrations at 10% w/v exhibited a non-Newtonian (shear-thinning) pseudoplastic behavior along with good extrudability characteristics through the extrusion nozzle. Thus, HPMC E15 can be applied as a 3D printing polymer for a syringe extrusion 3D printer.

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Mortars for 3D printing

MATEC Web of Conferences ◽

10.1051/matecconf/201814302013 ◽

2018 ◽

Vol 143 ◽

pp. 02013

Author(s):

Olga Demyanenko ◽

Ekaterina Sorokina ◽

Natalya Kopanitsa ◽

Yurij Sarkisov

Keyword(s):

3D Printing ◽

Cement Paste ◽

Chemical Interaction ◽

Early Age ◽

Hardened Cement ◽

Hardened Cement Paste ◽

Operational Characteristics ◽

Physico Chemical ◽

Key Factor ◽

Technical Specifications

The paper is aimed at developing scientifically proven compositions of mortars for 3D printing modified by a peat-based admixture with improved operational characteristics. The paper outlines the results of experimental research on hardened cement paste and concrete mixture with the use of modifying admixture MT-600 (thermally modified peat). It is found that strength of hardened cement paste increases at early age when using finely dispersed admixtures, which is the key factor for formation of construction and technical specifications of concrete for 3D printing technologies. The composition of new formations of hardened cement paste modified by MT-600 admixture were obtained, which enabled to suggest the possibility of their physico-chemical interaction while hardening.

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3D printing and characterization of hydroxypropyl methylcellulose and methylcellulose for biodegradable support structures

10.31274/etd-20200624-208 ◽

2020 ◽

Author(s):

Prashant Ramkrishna Polampally

Keyword(s):

3D Printing ◽

Hydroxypropyl Methylcellulose ◽

Support Structures

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Direct Cyclodextrin Based Powder Extrusion 3D Printing for One-step Production of the BCS Class II Model Drug Niclosamide

10.21203/rs.3.rs-965993/v1 ◽

2021 ◽

Author(s):

Monica Pistone ◽

Giuseppe Francesco Racaniello ◽

Ilaria Arduino ◽

Valentino Laquintana ◽

Antonio Lopalco ◽

...

Keyword(s):

3D Printing ◽

Hydroxypropyl Methylcellulose ◽

Class Ii ◽

Active Principle ◽

Fused Deposition Modelling ◽

Sustained Drug Release ◽

Pharmaceutical Dosage Forms ◽

Fused Deposition ◽

Bcs Class Ii

Abstract Niclosamide (NCS) is a drug that has been used as an anthelmintic and anti-parasitic active principle for about 40 years. Recently, some studies have highlighted its potential in treating various tumors, allowing a repositioning of this drug. Despite its potential, NCS is a Biopharmaceutical Classification System (BCS) Class II drug, and is consequently characterised by low aqueous solubility, poor dissolution rate and reduced bioavailability, which limits its applicability. In this work, we utilize a very novel technique, Direct Powder Extrusion (DPE) 3D printing, which overcomes the limitations of previously used techniques (Fused Deposition Modelling, FDM) to achieve direct extrusion of pharmaceutical grade powder mixtures consisting of NCS, hydroxypropyl methylcellulose (HPMC, Affinisol 15 LV), hydroxypropyl-b-cyclodextrin (HP-β-CD) and polyethylene glycol (PEG) 6000. For the first time, direct printing of powder blends containing HP-β-CD was explored. For all tablets, in vitro dissolution studies showed sustained drug release over 48 hours, but for tablets containing HP-β-CD, the release was faster. Solid-state characterisation studies showed that during extrusion, the drug lost its crystal structure and was evenly distributed within the polymer matrix. All printed tablets exhibited good mechanical and physical features and guarantee stability of the drug content for up to 3 months. This innovative printing technique has demonstrated the possibility to produce personalised pharmaceutical dosage forms starting directly from powders, avoiding the use of filament used by FDM.

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