Sense of agency in health and disease: A review of cue integration approaches

According to the Cue integration theory, the Sense of agency (SoA) is a resultant of both motor as well as non-motor cues, and these multiple cues are integrated based on their reliability or invariance estimate. However, the cue integration theory fails to make a distinction between perception and judgment, when it attributes (multisensory) perceptual character to non-motor cues like affect, effort, competition, fluency, familiarity, expertise, sleep, meditation, primes, and previews of actions, etc. Thus, my paper criticizes the experimentally operationalized cue-integrated SoA by arguing that: (a) there is uncertainty in the cue-integrated SoA experimental operationalization (making the participants prone to judgment effects); (b) the cue integration theory faces a problem of explaining how non-motor cues acquire interface, intentionality, and accuracy about agency; (c) the SoA reports are influenced by heuristic responding pattern (under uncertainty); (d) the cue-integrated SoA operationalizations had ‘inaccuracy standard’ for measuring perception of agency; (e) under certainty, the (nonveridical) SoA reports might not have occurred at all. This paper concludes that the reported heuristic responses (under uncertainty) of SoA can be parsimoniously accounted by compositionality nature of thought/judgment rather than the cue-integrated perception, and thus, the cue-integrated SoA reports are not instances of perceptions but are judgments.

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A Bayesian psychophysics model of sense of agency

Nature Communications ◽

10.1038/s41467-019-12170-0 ◽

2019 ◽

Vol 10 (1) ◽

Cited By ~ 8

Author(s):

Roberto Legaspi ◽

Taro Toyoizumi

Keyword(s):

Bayesian Model ◽

Formal Model ◽

Sense Of Agency ◽

Cue Integration ◽

Prior Belief ◽

Sensory Cues ◽

Intentional Binding ◽

High Confidence ◽

Binding Effect ◽

External Event

Abstract Sense of agency (SoA) refers to the experience or belief that one’s own actions caused an external event. Here we present a model of SoA in the framework of optimal Bayesian cue integration with mutually involved principles, namely reliability of action and outcome sensory signals, their consistency with the causation of the outcome by the action, and the prior belief in causation. We used our Bayesian model to explain the intentional binding effect, which is regarded as a reliable indicator of SoA. Our model explains temporal binding in both self-intended and unintentional actions, suggesting that intentionality is not strictly necessary given high confidence in the action causing the outcome. Our Bayesian model also explains that if the sensory cues are reliable, SoA can emerge even for unintended actions. Our formal model therefore posits a precision-dependent causal agency.

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A Bayesian psychophysics model of sense of agency

10.1101/433888 ◽

2018 ◽

Author(s):

Roberto Legaspi ◽

Taro Toyoizumi

Keyword(s):

Bayesian Model ◽

Formal Model ◽

Sense Of Agency ◽

Reliable Indicator ◽

Cue Integration ◽

Prior Belief ◽

Sensory Cues ◽

Intentional Binding ◽

High Confidence ◽

Binding Effect

AbstractDespite the increasing significance of sense of agency (SoA) research, the literature lacks a formal model: what computational principles underlie SoA, the registration that oneself initiated an action that caused something to happen? We theorize SoA in the framework of optimal Bayesian cue integration with mutually involved principles, namely, reliability of action and outcome sensory signals, their consistency with the causation of the outcome by the action, and the prior belief in causation. We used our Bayesian model to explain the intentional binding effect, hailed as reliable indicator of SoA. Our model explains temporal binding in both self-intended and unintentional actions suggesting that intentionality is not strictly necessary given high confidence in the action causing the outcome. Our Bayesian model also explains that if the sensory cues are reliable, SoA can emerge even for unintended actions. Our formal model therefore posits a precision-dependent causal agency.

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Right parietotemporal activity predicts sense of agency under uncertain delays of sensory outcomes

Journal of Neurophysiology ◽

10.1152/jn.00640.2020 ◽

2021 ◽

Vol 125 (3) ◽

pp. 903-914

Author(s):

Mahmoud Rashidi ◽

Mike Michael Schmitgen ◽

Matthias Weisbrod ◽

Knut Schnell ◽

Robert Christian Wolf ◽

...

Keyword(s):

Voluntary Movement ◽

Sense Of Agency ◽

Integration Theory ◽

Cue Integration ◽

First Time

According to the optimal cue integration theory, the formation of sense of agency relies on both predictive and postdictive agency cues and how they are weighted based on their availability and reliability. Using a novel paradigm, we show for the first time a possible existence of a prediction signal prior to voluntary movement, which appears when postdictive agency cues (i.e., the judgment of the time between voluntary movement and a subsequent flash) are not reliable.

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Drug Induced Changes in Cell Organelles

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100100299 ◽

1968 ◽

Vol 26 ◽

pp. 110-111

Author(s):

Sarah A. Luse

Keyword(s):

Clinical Medicine ◽

Cell Organelles ◽

Riboflavin Deficiency ◽

Drug Induced ◽

New Era ◽

Health And Disease ◽

In The Beginning ◽

Cellular Pathology ◽

Induced Changes ◽

The Impact

In the mid-nineteenth century Virchow revolutionized pathology by introduction of the concept of “cellular pathology”. Today, a century later, this term has increasing significance in health and disease. We now are in the beginning of a new era in pathology, one which might well be termed “organelle pathology” or “subcellular pathology”. The impact of lysosomal diseases on clinical medicine exemplifies this role of pathology of organelles in elucidation of disease today.Another aspect of cell organelles of prime importance is their pathologic alteration by drugs, toxins, hormones and malnutrition. The sensitivity of cell organelles to minute alterations in their environment offers an accurate evaluation of the site of action of drugs in the study of both function and toxicity. Examples of mitochondrial lesions include the effect of DDD on the adrenal cortex, riboflavin deficiency on liver cells, elevated blood ammonia on the neuron and some 8-aminoquinolines on myocardium.

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The Laryngeal Epithelium in Reflux

Perspectives on Voice and Voice Disorders ◽

10.1044/vvd21.3.112 ◽

2011 ◽

Vol 21 (3) ◽

pp. 112-117 ◽

Cited By ~ 2

Author(s):

Elizabeth Erickson-Levendoski ◽

Mahalakshmi Sivasankar

Keyword(s):

Laryngopharyngeal Reflux ◽

Critical Role ◽

Structure And Function ◽

Laryngeal Disease ◽

Health And Disease ◽

And Function ◽

The Impact

The epithelium plays a critical role in the maintenance of laryngeal health. This is evident in that laryngeal disease may result when the integrity of the epithelium is compromised by insults such as laryngopharyngeal reflux. In this article, we will review the structure and function of the laryngeal epithelium and summarize the impact of laryngopharyngeal reflux on the epithelium. Research investigating the ramifications of reflux on the epithelium has improved our understanding of laryngeal disease associated with laryngopharyngeal reflux. It further highlights the need for continued research on the laryngeal epithelium in health and disease.

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