Calling for a systems approach in microbiome research and innovation

Current research and innovation (R&I) systems are not equipped to fully serve as catalysts for the urgently needed transformation of food systems. Though research on food systems transformation (first order: ‘what?’) and transformative research (second order: ‘how to’) are rapidly gaining traction in academic and policy environments, current efforts fail to explicitly recognize the systemic nature of the challenges associated with performing transformative second-order research. To recognize these manifold and interlinked challenges embedded in R&I systems, there is a need for a coupled-systems perspective. Transformations are needed in food systems as well as R&I systems (‘how to do the “how to”’). We set out to conceptualize an approach that aims to trigger double transformations by nurturing innovations at the boundaries of R&I systems and food systems that act upon systemic leverage points, so that their multisystem interactions can better support food system transformations. We exemplify this coupled-systems approach by introducing the FIT4FOOD2030 project with its 25 living labs as a promising multilevel boundary innovation at the cross-section of R&I and food systems. We illustrate how this approach paves the way for double systems transformations, and therefore for an R&I system that is fit for future-proofing food systems.

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A Systems Approach to Achieve Equity in Healthcare Research

GetMobile Mobile Computing and Communications ◽

10.1145/3511285.3511287 ◽

2022 ◽

Vol 25 (3) ◽

pp. 5-11

Author(s):

Ashutosh Sabharwal ◽

Souptik Barua ◽

David Kerr

Keyword(s):

Systems Approach ◽

Negative Impact ◽

The United States ◽

Healthcare Research ◽

People Of Color ◽

Positive Health ◽

Predominantly Black ◽

Research And Innovation ◽

The Social ◽

Positive Health Outcomes

Healthcare in the United States is inequitable. The consequence of inequity is that the burden of serious chronic disease, such as diabetes, falls disproportionately on populations experiencing health disparities, predominantly Black, Indigenous, and people of color. [1] The reasons for the inequity include the negative impact of the social determinants of health of individuals and families from these communities, being underrepresented as participants in clinical research, having limited access to technologies that support self-care, and a lack of researchers and clinicians from these same populations. [2] To achieve equity and fairness, there is a need for a paradigm shift in healthcare research and innovation based on improving access, trust, and self-efficacy [3] to convert new knowledge into positive health outcomes.

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Combining integrated systems-biology approaches with intervention-based experimental design provides a higher-resolution path forward for microbiome research

Behavioral and Brain Sciences ◽

10.1017/s0140525x18002911 ◽

2019 ◽

Vol 42 ◽

Author(s):

J. Alfredo Blakeley-Ruiz ◽

Carlee S. McClintock ◽

Ralph Lydic ◽

Helen A. Baghdoyan ◽

James J. Choo ◽

...

Keyword(s):

Systems Biology ◽

High Resolution ◽

Experimental Design ◽

Integrated Systems ◽

Microbiome Research ◽

Constructive Criticism

Abstract The Hooks et al. review of microbiota-gut-brain (MGB) literature provides a constructive criticism of the general approaches encompassing MGB research. This commentary extends their review by: (a) highlighting capabilities of advanced systems-biology “-omics” techniques for microbiome research and (b) recommending that combining these high-resolution techniques with intervention-based experimental design may be the path forward for future MGB research.

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Inter-individual variation shapes the human microbiome

Behavioral and Brain Sciences ◽

10.1017/s0140525x1800287x ◽

2019 ◽

Vol 42 ◽

Author(s):

Emily F. Wissel ◽

Leigh K. Smith

Keyword(s):

Individual Differences ◽

Individual Variation ◽

Human Microbiome ◽

Individual Variability ◽

Microbiota Composition ◽

Target Article ◽

Microbiome Research

Abstract The target article suggests inter-individual variability is a weakness of microbiota-gut-brain (MGB) research, but we discuss why it is actually a strength. We comment on how accounting for individual differences can help researchers systematically understand the observed variance in microbiota composition, interpret null findings, and potentially improve the efficacy of therapeutic treatments in future clinical microbiome research.

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A Dynamic Systems Approach to Personality

European Psychologist ◽

10.1027//1016-9040.6.3.172 ◽

2001 ◽

Vol 6 (3) ◽

pp. 172-176 ◽

Cited By ~ 14

Author(s):

Lawrence A. Pervin

Keyword(s):

Dynamic Systems ◽

Systems Approach ◽

Biological Processes ◽

Recent Advances ◽

Dynamic View ◽

The Future ◽

History Of

David Magnusson has been the most articulate spokesperson for a holistic, systems approach to personality. This paper considers three concepts relevant to a dynamic systems approach to personality: dynamics, systems, and levels. Some of the history of a dynamic view is traced, leading to an emphasis on the need for stressing the interplay among goals. Concepts such as multidetermination, equipotentiality, and equifinality are shown to be important aspects of a systems approach. Finally, attention is drawn to the question of levels of description, analysis, and explanation in a theory of personality. The importance of the issue is emphasized in relation to recent advances in our understanding of biological processes. Integrating such advances into a theory of personality while avoiding the danger of reductionism is a challenge for the future.

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