Interest in the biological role of bioactive compounds present in medicinal herbs has increased over the last years. Of
particular interest are plants that have an anti-Alzheimer activities. Several plants can be useful for Alzheimer (AD)
management. Such as these which have anti-inflammatory activity, acetylcholinesterase (AChE) inhibitory action, antiapoptotic,
slow the aggregation of amyloid peptide and antioxidant activities. Grape seed extract (GSE) is a complex
mixture of several compounds, mostly represented by polyphenols and flavonoids. Their consumption is safe and is
recognized to exert several health benefits. GS flavonoids have been associated with the reduced risk of chronic diseases,
we present some findings on the potential benefits of GSE for the treatment of AD.