Grape Seeds Extract as Brain Food: A Review

Interest in the biological role of bioactive compounds present in medicinal herbs has increased over the last years. Of particular interest are plants that have an anti-Alzheimer activities. Several plants can be useful for Alzheimer (AD) management. Such as these which have anti-inflammatory activity, acetylcholinesterase (AChE) inhibitory action, antiapoptotic, slow the aggregation of amyloid peptide and antioxidant activities. Grape seed extract (GSE) is a complex mixture of several compounds, mostly represented by polyphenols and flavonoids. Their consumption is safe and is recognized to exert several health benefits. GS flavonoids have been associated with the reduced risk of chronic diseases, we present some findings on the potential benefits of GSE for the treatment of AD.

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Chemotherapeutic Agent-induced Nephrotoxicity in Rabbits: Protective Role of Grape Seed Extract

International Journal of Pharmacology ◽

10.3923/ijp.2012.39.45 ◽

2011 ◽

Vol 8 (1) ◽

pp. 39-45 ◽

Cited By ~ 3

Author(s):

Fulya Benzer ◽

Fatih Mehmet Kandemir ◽

Songul Ceribasi ◽

Mustafa Ozkaraca ◽

Nuran Cikcikoglu Yildirim ◽

...

Keyword(s):

Chemotherapeutic Agent ◽

Grape Seed Extract ◽

Grape Seed ◽

Protective Role ◽

Seed Extract

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Role of oxidative stress in cytotoxicity of grape seed extract in human bladder cancer cells

Food and Chemical Toxicology ◽

10.1016/j.fct.2013.06.039 ◽

2013 ◽

Vol 61 ◽

pp. 187-195 ◽

Cited By ~ 14

Author(s):

Komal Raina ◽

Alpna Tyagi ◽

Dileep Kumar ◽

Rajesh Agarwal ◽

Chapla Agarwal

Keyword(s):

Oxidative Stress ◽

Bladder Cancer ◽

Grape Seed Extract ◽

Grape Seed ◽

Seed Extract ◽

Human Bladder Cancer ◽

Human Bladder ◽

Bladder Cancer Cells ◽

Human Bladder Cancer Cells

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A study on antibacterial effect of grape seed extracts in common clinical and drug resistant isolates

International Journal of Clinical Trials ◽

10.18203/2349-3259.ijct20162799 ◽

2016 ◽

Vol 3 (3) ◽

pp. 165

Author(s):

Mohanakrishnan Kandasamy ◽

Sowmya Nasimuddin ◽

Jeevan Malayan ◽

Nithyalakshmi J ◽

Sumathi Gnanadesikan ◽

...

Keyword(s):

Antibacterial Effect ◽

Grape Seed Extract ◽

Grape Seed ◽

Seed Extract ◽

Clinical Isolates ◽

Drug Resistant ◽

Grape Seeds ◽

Mrsa Strains ◽

Agar Well Diffusion Assay ◽

Grape Seed Extracts

Background: Grape seeds are proposed to have antimicrobial activity, antioxidant effect and various other benefits to mankind. A study was done to assess the antibacterial effect of grape seed extract against common clinical isolates and drug resistant pathogenic strains.Methods: Grape seed extract prepared was investigated for its antibacterial effect against 65 bacterial isolates obtained from clinical specimens by agar well diffusion assay and the results were compared with routinely used antibiotics namely, Gentamicin for the common clinical isolates, Vancomycin for MRSA strains and Amikacin for ESBL organisms respectively.Results: Grape seed extract produced moderate zone of inhibition ranging between 11-15 mm among the 35 test common clinical isolates namely Staphylococcus aureus, Escherichia coli, Klebsiella sp and Pseudomonas aeruginosa. E.coli showed the highest susceptibility with zone ranging from 12-14 mm with increasing concentration of the extract starting from2 mg/ml to the highest being 20 mg/ml. Among the 30 drug resistant pathogenic strains like MRSA and ESBL producing organisms, the grape seed extract was found to be effective against 3 out of the 10 of MRSA and 2 out of the 10 of ESBL-E.coli at the highest concentration of 20 mg/ml. However, ESBL producing Klebsiella species were found to be resistant even to the highest concentration of the extract. Conclusions: The results provide evidence that the grape seed extract could be a potential antibacterial agent and this effect can further be made evident with improved methodologies.

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Grape seed extract induces anoikis and caspase-mediated apoptosis in human prostate carcinoma LNCaP cells: possible role of ataxia telangiectasia mutated–p53 activation

Molecular Cancer Therapeutics ◽

10.1158/1535-7163.mct-06-0014 ◽

2006 ◽

Vol 5 (5) ◽

pp. 1265-1274 ◽

Cited By ~ 51

Author(s):

Manjinder Kaur ◽

Rajesh Agarwal ◽

Chapla Agarwal

Keyword(s):

Prostate Carcinoma ◽

Ataxia Telangiectasia ◽

Grape Seed Extract ◽

Grape Seed ◽

Seed Extract ◽

Lncap Cells ◽

Ataxia Telangiectasia Mutated ◽

Human Prostate Carcinoma ◽

P53 Activation

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Critical role of grape seed extract on Hodgkin lymphoma through controls the cell cycle

American Journal of BioMedicine ◽

10.18081/2333-5106/015-07/392-402 ◽

2015 ◽

Vol 3 (7) ◽

pp. 392-402

Author(s):

Maurizio Fracchiolla ◽

Mark McKenna ◽

Kaisa Zaman ◽

Patrick Becker ◽

Thomas Terraz

Keyword(s):

Cell Cycle ◽

Hodgkin Lymphoma ◽

Critical Role ◽

Grape Seed Extract ◽

Grape Seed ◽

Seed Extract

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The possible neuroprotective role of grape seed extract on the histopathological changes of the cerebellar cortex of rats prenatally exposed to Valproic Acid: animal model of autism

Acta Histochemica ◽

10.1016/j.acthis.2019.08.002 ◽

2019 ◽

Vol 121 (7) ◽

pp. 841-851 ◽

Cited By ~ 5

Author(s):

Eetmad A. Arafat ◽

Dalia A. Shabaan

Keyword(s):

Valproic Acid ◽

Animal Model ◽

Cerebellar Cortex ◽

Grape Seed Extract ◽

Grape Seed ◽

Seed Extract ◽

Prenatally Exposed ◽

Histopathological Changes

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Modulatory role of grape seed extract on age-related oxidative DNA damage in central nervous system of rats

Brain Research Bulletin ◽

10.1016/j.brainresbull.2005.10.007 ◽

2006 ◽

Vol 68 (6) ◽

pp. 469-473 ◽

Cited By ~ 55

Author(s):

Muthaiya Balu ◽

Purushotham Sangeetha ◽

Ganesan Murali ◽

Chinnakannu Panneerselvam

Keyword(s):

Central Nervous System ◽

Dna Damage ◽

Nervous System ◽

Oxidative Dna Damage ◽

Grape Seed Extract ◽

Grape Seed ◽

Seed Extract ◽

Age Related

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Effects of Polyphenols from Grape Seeds on Renal Lithiasis

Oxidative Medicine and Cellular Longevity ◽

10.1155/2015/813737 ◽

2015 ◽

Vol 2015 ◽

pp. 1-6 ◽

Cited By ~ 12

Author(s):

Felix Grases ◽

Rafel M. Prieto ◽

Rafel A. Fernandez-Cabot ◽

Antonia Costa-Bauzá ◽

Fernando Tur ◽

...

Keyword(s):

Ethylene Glycol ◽

Calcium Oxalate ◽

Complex Disease ◽

Urine Analysis ◽

Calcium Oxalate Monohydrate ◽

Grape Seed Extract ◽

Grape Seed ◽

Oxidative Capacity ◽

Seed Extract ◽

Grape Seeds

Nephrolithiasis is a complex disease that results from a combination of factors related to both urine composition and kidney morphoanatomy. Development of calcium oxalate monohydrate papillary calculi is linked to initial subepithelial calcification of renal papilla. Progressive tissue calcification depends on preexisting injury and involves reactive oxygen species. Many plant extracts that protect against oxidative stress manifest antilithiasic activity. Our study focused on determining the effects of polyphenols on a lithiasis rat model. Rats were pretreated with polyphenols and grape seed extracts, followed by posterior induction of hyperoxalosis via treatment with ethylene glycol plus NH4Cl. The concentrations of calcium and other elements in kidney were determined, along with histological examination of kidney and 24 h urine analysis. Significant differences were observed in the renal calcium content between the control plus ethylene glycol-treated group and the epicatechin plus ethylene glycol-treated, red grape seed extract plus ethylene glycol-treated, and white grape seed extract plus ethylene glycol-treated groups, with reductions of about 50%. The antioxidant activity of polyphenols extracted from red and white grape seeds may be critical in the prevention of calcium oxalate monohydrate papillary calculus formation, particularly if calculi are induced by lesions caused by cytotoxic compounds with oxidative capacity.

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