scholarly journals Effects of sulfasalazine on lipid peroxidation and histologic liver damage in a rat model of obstructive jaundice and obstructive jaundice with lipopolysaccharide-induced sepsis

2009 ◽  
Vol 70 (4) ◽  
pp. 299-315 ◽  
Author(s):  
Musa Dirlik ◽  
Aydin Karahan ◽  
Hakan Canbaz ◽  
Mehmet Caglikulekci ◽  
Ayşe Polat ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Obstructive Jaundice ◽  
Liver Damage ◽  
Rat Model

Supplementation with Fetal-Specific Factors Ameliorates Oxidative Liver Damage During Hypothermic Storage and Reperfusion in a Rat Model

2005 ◽  
Vol 3 (3) ◽  
pp. 201-209 ◽  
Author(s):  
D.V. Cherkashina ◽  
O.A. Semenchenko ◽  
V.P. Grischuk ◽  
B.J. Fuller ◽  
A. Yu. Petrenko
Keyword(s):  
Liver Damage ◽  
Rat Model ◽  
Specific Factors ◽  
Hypothermic Storage

Involvement of striatal lipid peroxidation and inhibition of calcium influx into brain slices in neurobehavioral alterations in a rat model of short-term oral exposure to manganese

2008 ◽  
Vol 29 (6) ◽  
pp. 1062-1068 ◽  
Author(s):  
Daiana Silva Ávila ◽  
Priscila Gubert ◽  
Roselei Fachinetto ◽  
Caroline Wagner ◽  
Michael Aschner ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Rat Model ◽  
Calcium Influx ◽  
Brain Slices ◽  
Oral Exposure ◽  
Short Term

scholarly journals CHEMICAL COMPOSITION AND HEPATOPROTECTIVE EFFECTS OF POLYPHENOLIC FRACTION FROM RIVEA HYPOCRATERIFORMIS IN PARACETAMOL INDUCED LIVER DAMAGE IN WISTAR ALBINO RATS

2016 ◽  
Vol 8 (10) ◽  
pp. 228
Author(s):  
Shivakumar S. Godipurge ◽  
Naveen J. Biradar ◽  
Jaiprakash S. Biradar ◽  
Nitin Mahurkar
Keyword(s):  
Lipid Peroxidation ◽  
Chemical Composition ◽  
Hydroxyl Radical ◽  
Liver Damage ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Scavenging Activity ◽  
Aerial Parts ◽  
Hepatoprotective Effects ◽  
Phenolic And Flavonoid

<p><strong>Objective: </strong>This study was designed to chemical composition and hepatoprotective effects of a polyphenolic fraction of aerial parts of <em>R. hypocrateriformis </em>(PPFRH). It was shown to exhibit strong <em>in vitro</em> lipid peroxidation and scavenging activity against hydroxyl radical.</p><p><strong>Methods: </strong>The chemical composition of a polyphenolic fraction of <em>R. hypocrateriformis</em> was analyzed by High-performance liquid chromatography method. Hepatocellular injuries induced by paracetamol were assessed by liver damage in Wistar albino rat; the hepatoprotective effect was evaluated by biochemical parameters in rat serum, antioxidant hydroxyl radical scavenging activity and lipid peroxidation in liver tissue.</p><p><strong>Results: </strong>The polyphenolic fraction of aerial parts of <em>R. hypocrateriformis</em> for lipid peroxidation is significantly (p&lt;0.05). In the hepatoprotective activity of liver enzymes and hepatic necrosis were significantly (p&lt;0.001) closer to paracetamol. The correlation coefficient between the hydroxyl scavenging radical and total phenolic and flavonoid contents were found to be R² = 0.9045 and R² = 0.8876 suggesting the contribution of phenolic and flavonoid compounds of the polyphenolic fraction of aerial parts of <em>R. hypocrateriformis</em> by 90% and 88% to its radical scavenging activity.</p><p><strong>Conclusion: </strong>The polyphenolic fraction of aerial parts of <em>R. hypocrateriformis</em> possesses a significant protective effect against acute hepatotoxicity induced by paracetamol and which may be due to the phenolic and flavonoid components.</p>

Agmatine alleviates hepatic and renal injury in a rat model of obstructive jaundice

2020 ◽  
Vol 13 ◽  
pp. 100212 ◽  
Author(s):  
Mohammad Mehdi Ommati ◽  
Omid Farshad ◽  
Khadijeh Mousavi ◽  
Rasool Taghavi ◽  
Saeed Farajvajari ◽  
...  
Keyword(s):  
Obstructive Jaundice ◽  
Rat Model ◽  
Renal Injury

Superiority of Ceftriaxon to Cefazolin in a Rat Model of Obstructive Jaundice: An Experimental Study

2012 ◽  
Vol 26 (1) ◽  
pp. 11-15
Author(s):  
Enver Reyhan ◽  
Mustafa Duman ◽  
Yeliz Demirci ◽  
Ali Emre Atici ◽  
Mahmut Ozer ◽  
...  
Keyword(s):  
Experimental Study ◽  
Obstructive Jaundice ◽  
Rat Model

Lactobacilli modulated AMPK activity and prevented telomere shortening in ageing rats

2019 ◽  
Vol 10 (8) ◽  
pp. 883-892
Author(s):  
L.C. Lew ◽  
Y.Y. Hor ◽  
M.H. Jaafar ◽  
A.S.Y. Lau ◽  
J.S. Ong ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Rat Model ◽  
High Fat Diet ◽  
Lactobacillus Reuteri ◽  
Plasma Lipid ◽  
Dependent Manner ◽  
Sprague Dawley ◽  
High Fat ◽  
Age Related ◽  
Plasma Lipid Peroxidation

This study aimed to evaluate the anti-ageing effects of different strains of lactobacilli putative probiotics on an ageing rat model as induced by D-galactose and a high fat diet. Male Sprague-Dawley rats were fed with high fat diet (54% kcal fat) and injected with D-galactose daily for 12 weeks to induce ageing. The effects of putative probiotic strains on age-related impairment such as telomere length, plasma lipid peroxidation, hepatic 5’adenosine monophosphate-activated protein kinase (AMPK) expression, as well as endurance performance were evaluated. Administration of statin, Lactobacillus plantarum DR7 (LP-DR7), Lactobacillus fermentum DR9 (LF-DR9), and Lactobacillus reuteri 8513d (LR-8513d) significantly reduced the shortening of telomere and increased the expression of AMPK subunit-α1 (P<0.05). Plasma lipid peroxidation was lower (P<0.05) in groups administered with statin and LF-DR9 as compared to the control. AMPK subunit-α2 was elevated in rats administered with LP-DR7 as compared to the control (P<0.05). Using an in vivo ageing rat model, the current study has illustrated the potentials of lactobacilli putative probiotics in alleviation of age-related impairment in a strain-dependent manner.

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