O036 IL-17-producing gamma-delta T cells are crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice

Cytokine ◽  
2012 ◽  
Vol 59 (3) ◽  
pp. 514
Author(s):  
A. Akitsu ◽  
H. Ishigame ◽  
S. Kakuta ◽  
S. Saijo ◽  
Y. Iwakura
Keyword(s):  
T Cells ◽  
Receptor Antagonist ◽  
Autoimmune Arthritis ◽  
Gamma Delta T Cells ◽  
Gamma Delta ◽  
Deficient Mice

scholarly journals Most gamma delta T cells develop normally in beta 2-microglobulin-deficient mice.

1992 ◽  
Vol 89 (2) ◽  
pp. 653-657 ◽  
Author(s):  
I. Correa ◽  
M. Bix ◽  
N. S. Liao ◽  
M. Zijlstra ◽  
R. Jaenisch ◽  
...  
Keyword(s):  
T Cells ◽  
Gamma Delta T Cells ◽  
Gamma Delta ◽  
Beta 2 ◽  
Beta 2 Microglobulin ◽  
Deficient Mice

scholarly journals A tumor-suppressor function for Fas (CD95) revealed in T cell-deficient mice.

1996 ◽  
Vol 184 (3) ◽  
pp. 1149-1154 ◽  
Author(s):  
S L Peng ◽  
M E Robert ◽  
A C Hayday ◽  
J Craft
Keyword(s):  
T Cells ◽  
Tumor Suppressor ◽  
B Cell ◽  
Malignant Tumors ◽  
B Cell Lymphoma ◽  
Immunoglobulin M ◽  
Gamma Delta T Cells ◽  
Gamma Delta ◽  
Alpha Beta ◽  
Deficient Mice

Fas (CD95) and its ligand are central regulatory molecules in hematopoietic cells. Previous studies have suggested a role for Fas in the regulation of tumor progression, but Fas has not yet been conclusively identified as a tumor suppressor. Fas-deficient individuals lack malignant tumors, perhaps because of regulation by T cells. To investigate such a possibility, mice deficient in both T cells and Fas were generated, and they were found to develop severe B cell dysregulation characterized by malignant, lethal B cell lymphoma. Lymphoma arose from a monoclonal B220+CD19-CD5-CD23- B cell secreting immunoglobulin M, kappa rheumatoid factor. In contrast, animals containing alpha beta T cells, gamma delta T cells, and/or functional Fas suppressed the development of lymphoma. These data indicate that Fas functions as a tumor suppressor, and identifies roles for both alpha beta T cells and gamma delta T cells in Fas-independent tumor regulation.

scholarly journals Preferential usage of the Fc receptor gamma chain in the T cell antigen receptor complex by gamma/delta T cells localized in epithelia.

1994 ◽  
Vol 179 (1) ◽  
pp. 365-369 ◽  
Author(s):  
H Ohno ◽  
S Ono ◽  
N Hirayama ◽  
S Shimada ◽  
T Saito
Keyword(s):  
T Cells ◽  
T Cell ◽  
Antigen Receptor ◽  
Gamma Delta T Cells ◽  
Gamma Delta ◽  
Gamma Chain ◽  
T Cell Antigen Receptor ◽  
Cell Antigen Receptor ◽  
Cell Antigen ◽  
Deficient Mice

zeta and eta chains of the T cell antigen receptor (TCR) complex and the gamma chain of Fc receptors (FcR gamma) constitute a family of proteins important for the expression of, and signal transduction through, these receptors in hematopoietic cells. In zeta-deficient mice, TCR expression was reduced in most T cells. By contrast, CD8 alpha alpha + TCR-gamma/delta + intestinal intraepithelial lymphocytes in these mice expressed a normal level of TCR. Biochemical analysis of the TCR complex in these cells from zeta-deficient as well as normal mice revealed the predominant usage of FcR gamma. Furthermore, gamma/delta + T cells in epithelia of the skin and female reproductive organs from zeta-deficient mice also showed relatively high TCR expression, indicating the usage of FcR gamma. These observations demonstrate the preferential usage of FcR gamma by gamma/delta + T cells localized in epithelia of normal mice.

scholarly journals IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2+Vγ6+γδ T cells

2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Aoi Akitsu ◽  
Harumichi Ishigame ◽  
Shigeru Kakuta ◽  
Soo-hyun Chung ◽  
Satoshi Ikeda ◽  
...  
Keyword(s):  
T Cells ◽  
Receptor Antagonist ◽  
Γδ T Cells ◽  
Autoimmune Arthritis ◽  
Deficient Mice

scholarly journals Gamma delta T cells contribute to immunity against the liver stages of malaria in alpha beta T-cell-deficient mice.

1994 ◽  
Vol 91 (1) ◽  
pp. 345-349 ◽  
Author(s):  
M. Tsuji ◽  
P. Mombaerts ◽  
L. Lefrancois ◽  
R. S. Nussenzweig ◽  
F. Zavala ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Gamma Delta T Cells ◽  
Gamma Delta ◽  
Alpha Beta ◽  
Deficient Mice

Gamma/Delta T Cells from Tolerized Alpha/Beta-TCR-Deficient Mice Antigen Specifically Inhibit Contact Sensitivity in vivo and IFN-Gamma Production in vitro

1997 ◽  
Vol 113 (1-3) ◽  
pp. 373-375 ◽  
Author(s):  
Marian Szczepanik ◽  
Laurel R. Anderson ◽  
Hiroko Ushio ◽  
Wlodzimierz Ptak ◽  
Michael J. Owen ◽  
...  
Keyword(s):  
T Cells ◽  
Gamma Delta T Cells ◽  
Contact Sensitivity ◽  
Gamma Delta ◽  
Ifn Gamma ◽  
Alpha Beta ◽  
Deficient Mice

Anti-Tumor Actions of Trametes Versicolor Extract Polysaccharide K Include Activation of Dendritic Cells and Gamma Delta T Cells

Planta Medica ◽  
2013 ◽  
Vol 79 (10) ◽  
Author(s):  
CA Wenner ◽  
C Inatsuka ◽  
T Davis Smith ◽  
M Sasagawa ◽  
MR Martzen ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Trametes Versicolor ◽  
Gamma Delta T Cells ◽  
Gamma Delta ◽  
Polysaccharide K

600 In vitro anticancer and immunomodulatory activities of NBT-167, a dimer of resveratrol

2020 ◽  
Vol 8 (Suppl 3) ◽  
pp. A635-A635
Author(s):  
Jeffrey Zhang ◽  
Everett Henry ◽  
L Harris Zhang ◽  
Wanying Zhang
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Immune Cells ◽  
Cell Killing ◽  
Gamma Delta T Cells ◽  
Gamma Delta ◽  
Raw264.7 Macrophages

BackgroundResveratrol (3,4’,5-trihydroxystilbene), a stilbenoid isolated from many species of plants, is widely known for its antioxidative, anti-inflammatory, immunomodulatory and anticancer activities. Recently, novel resveratrol oligomers have been isolated from various plants; their diverse structures are characterized by the polymerization of two or more resveratrol units. Little is known regarding the anticancer and immunomodulating activities of these oligomers. In this study, we designed in vitro models to compare resveratrol side by side with its natural dimer NBT-167 for their anticancer and immunological activities.MethodsWe isolated resveratrol and its dimer (NBT-167) from plants. The potency of the compounds was compared side by side using cancer cell survival assays and immunological assays with various types of human cells including cancer cell lines, PBMCs and enriched NK, gamma delta T cells, THP-1 monocytic cells, HL-60 promyelocytic leukemia cells as well as mouse RAW264.7 macrophages.ResultsNBT-167 was found to be more potent than resveratrol in inhibiting growth of various cancer cells and modulation of cytokine production from anti-IgM, LPS, PHA or SEB stimulated PBMC. Both compounds similarly enhanced IL-2 stimulated NK and gamma delta T cell killing activity against K562 cells and modulated nitric oxide production from LPS/IFN-g induced RAW264.7 macrophages and phagocytotic activity of HL-60 cells. NBT-167 was slightly more potently than resveratrol in inhibiting chemotaxis of HL-60 cells and blocking cell cycle of THP-1 and HL-60 cells at G1/S transition. In addition, NBT-167, but not resveratrol, could increase IL-2 production and T cell proliferation stimulated with anti-CD3 and anti-CD28 and synergize with anti-PD-1 antibody to increase IL-2 and IFN-gamma production in co-culture of allotypic T cells and dendric cells (MLR).ConclusionsOur data showed that NBT-167, a dimer of resveratrol, had anticancer and immunomodulatory activities such as modulation of expression of cytokines in immune cells and induction of cancer cell-killing activities of NK and gamma delta T cells. Generally, NBT-167 appeared to have higher activities than resveratrol in modulating immune cells and inhibiting cancer cells. NBT-167 could be a promising cancer immunotherapeutic agent targeting both cancer cells and immune cells.

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