Elevated serum levels of proinflammatory cytokines potentially correlate with depression and anxiety in colorectal cancer patients in different stages of the antitumor therapy

Background The aim of the present study was to determine whether serum vascular endothelial growth factor (VEGF) can provide prognostic information independent of carcinoembryonic antigen levels in patients undergoing curative surgery. Methods Serum samples were collected from 158 patients with colorectal cancer and from 100 controls. Serum and tissue levels of VEGF were measured by enzyme-linked immunosorbent assay. Serum VEGF levels in colorectal cancer patients were compared with those in healthy controls, and we retrospectively assessed the association between serum VEGF levels and clinicopathologic findings and survival. Results VEGF expression was significantly higher in colorectal cancer tissue compared with nontumor tissue. Mean serum VEGF levels in patients were significantly higher than those in controls, and significantly higher in patients with large tumors, lymph node involvement, and distant metastases. Conclusion Elevated serum VEGF was significantly associated with poor survival, but was only an independent risk factor for poor survival in Stage II and/or III disease. Elevated serum VEGF is significantly associated with development of colorectal cancer, and lymph or distant invasive phenotypes and survival, especially in Stage II and III patients.

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Postoperative Serum Levels of sCD26 for Surveillance in Colorectal Cancer Patients

PLoS ONE ◽

10.1371/journal.pone.0107470 ◽

2014 ◽

Vol 9 (9) ◽

pp. e107470 ◽

Cited By ~ 10

Author(s):

Loretta De Chiara ◽

Ana M. Rodríguez-Piñeiro ◽

Oscar J. Cordero ◽

Lidia Vázquez-Tuñas ◽

Daniel Ayude ◽

...

Keyword(s):

Colorectal Cancer ◽

Cancer Patients ◽

Serum Levels ◽

Postoperative Serum ◽

Colorectal Cancer Patients

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Association between VEGF expression in tumour-associated macrophages and elevated serum VEGF levels in primary colorectal cancer patients

Cancer Biomarkers ◽

10.3233/cbm-2007-3606 ◽

2007 ◽

Vol 3 (6) ◽

pp. 325-333 ◽

Cited By ~ 11

Author(s):

Francisco J. Gonzalez ◽

Luis Vicioso ◽

Martina Alvarez ◽

Isabel Sevilla ◽

Eduardo Marques ◽

...

Keyword(s):

Colorectal Cancer ◽

Cancer Patients ◽

Elevated Serum ◽

Primary Colorectal Cancer ◽

Vegf Expression ◽

Colorectal Cancer Patients

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Composition and Concentration of Serum Fatty Acids of Phospholipids Depend on Tumour Location and Disease Progression in Colorectal Patients

Journal of Medical Biochemistry ◽

10.1515/jomb-2017-0031 ◽

2018 ◽

Vol 37 (1) ◽

pp. 39-45 ◽

Cited By ~ 3

Author(s):

Jolanta Bugajska ◽

Joanna Berska ◽

Diana Hodorowicz-Zaniewska ◽

Krystyna Sztefko

Keyword(s):

Colorectal Cancer ◽

Fatty Acids ◽

Disease Progression ◽

Cancer Patients ◽

Distal Colon ◽

Unsaturation Index ◽

Serum Levels ◽

Colorectal Tumour ◽

Tumour Localization ◽

Colorectal Cancer Patients

SummaryBackground: Polyunsaturated fatty acids (PUFAs) play a role in the development/progression of colon cancer. The aim of the study was to assess the relation between serum phospholipids PUFAs, colorectal tumour localization and disease progression. Methods: A total of 67 patients (18 with proximal colon, 17 with distal colon and 32 with rectal tumour localization) as well as 16 controls were studied. One year after surgery, 33 patients had disease progression. Serum levels of C16:1(n-7), C18:1(n-9), C18:3(n-3), C20:5(n-3), C22:6(n- 3), C18:2(n-6), C20:2(n-6), C20:4(n-6) fatty acids of se - rum phospholipids were quantitatively measured before surgery by gas-chromatography. Results: Significantly higher mean value of C18:2, as compared to control, has been noted only for patients with proximal (p<0.05) and distal tumour (p<0.03) localization. The lower mean level of C20:5 and unsaturation index (UI) were observed in colorectal cancer patients regardless the tumour localization, but the statistical difference was noted only for patients with proximal tumours (p<0.05, p<0.03). In patients with proximal tumours, significantly lower mean level of C20:4 and UI were noted in patients with disease progression, as compared to patients with proximal tumours without disease progression (p<0.05). Conclusion: The evaluation of PUFAs as a risk/prognostic factor in colorectal cancer patients should take into account tumour localization as a dependent variable.

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Serum levels of tissue factor in colorectal cancer patients

International Journal of Clinical Oncology ◽

10.1007/bf02628048 ◽

1998 ◽

Vol 3 (5) ◽

pp. 287-290

Author(s):

Chika Shigemori

Keyword(s):

Colorectal Cancer ◽

Cancer Patients ◽

Tissue Factor ◽

Serum Levels ◽

Colorectal Cancer Patients

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Proinflammatory cytokines as predictive factors for response to chemotherapy or mental disorders present in colorectal cancer patients

Annals of Oncology ◽

10.1093/annonc/mdz155.230 ◽

2019 ◽

Vol 30 ◽

pp. iv63-iv64

Author(s):

C. Burz ◽

A. Bojan ◽

L. Balacescu ◽

C. Lisencu ◽

E. Puscas ◽

...

Keyword(s):

Colorectal Cancer ◽

Mental Disorders ◽

Cancer Patients ◽

Proinflammatory Cytokines ◽

Predictive Factors ◽

Response To Chemotherapy ◽

Colorectal Cancer Patients

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KCNB1 gene polymorphisms and related indel as predictor biomarkers of treatment response for colorectal cancer – toward a personalized medicine

Tumor Biology ◽

10.1177/1010428320925237 ◽

2020 ◽

Vol 42 (6) ◽

pp. 101042832092523 ◽

Cited By ~ 2

Author(s):

Mouadh Barbirou ◽

Ikram Sghaier ◽

Sinda Bedoui ◽

Rahma Ben Abderrazek ◽

Hazar Kraiem ◽

...

Keyword(s):

Colorectal Cancer ◽

Treatment Response ◽

Cancer Patients ◽

Serum Levels ◽

Amplification Refractory Mutation System ◽

Specific Response ◽

Tumor Localization ◽

Gene Variants ◽

Treatment And Prevention ◽

Colorectal Cancer Patients

The KCNB1 gene variants were differentially associated with cancers. However, their association with colorectal cancer has not yet been explored. We investigated the contribution of the KCNB1 gene variants rs3331, rs1051295, and indel (insertion/deletion) rs11468831 Polymorphism as predictors of the treatment response in colorectal cancer patients. A retrospective study, which involved 291 Tunisian colorectal cancer patients (aged 60.0 ± 13.1 years), who were stratified into responder and non-responder groups, according to TNM stages and their responsiveness to chemotherapy based on fluorouracil. KCNB1 genotyping was performed with amplification-refractory mutation system–polymerase chain reaction, and was confirmed by Sanger sequencing. Sex-specific response was found and colorectal cancer females are less likely to achieve a positive response during the chemotherapy strategy, compared to males. Weight and body mass index, tumor size, and tumor localization are considered as predictive factors to treatment responsiveness. Carriage of rs11468831 Ins allele was significantly associated with successful therapy achievement ( p adjusted < 0.001). Stratification of colorectal cancer patients’ response according to tumor localization and TNM stages reveals negative association of rs3331 Major allele to treatment response among the patients with advanced cancer stages (subgroup G2). The presence of rs3331 (homozygous minor) C/C genotype was positively associated with decline in carcino-embryonic antigen ( p = 0.043) and CA19-9 ( p = 0.014) serum levels. On the other hand, the presence of rs1051295 (homozygous minor) A/A genotype was correlated with marked decline in CA19-9 serum levels. KCNB1 haplotype did not reveal any association between haplotypes and treatment response. The results obtained suggest that gender-specific strategies for screening treatment and prevention protocols as well as KCNB1 variants may constitute an effective model for ongoing personalization medicine.

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