scholarly journals Unfolded Protein Response Genes Regulated by CED-1 Are Required for Caenorhabditis elegans Innate Immunity

2008 ◽  
Vol 15 (1) ◽  
pp. 87-97 ◽  
Author(s):  
Kylie A. Haskins ◽  
Jonathan F. Russell ◽  
Nathan Gaddis ◽  
Holly K. Dressman ◽  
Alejandro Aballay
Keyword(s):  
Innate Immunity ◽  
Caenorhabditis Elegans ◽  
Unfolded Protein Response ◽  
Unfolded Protein ◽  
Protein Response

scholarly journals A salicylic acid derivative extends the lifespan of Caenorhabditis elegans by activating autophagy and the mitochondrial unfolded protein response

Aging Cell ◽  
2018 ◽  
Vol 17 (6) ◽  
pp. e12830 ◽  
Author(s):  
Mehrnaz Shamalnasab ◽  
Simon-Pierre Gravel ◽  
Julie St-Pierre ◽  
Lionel Breton ◽  
Sibylle Jäger ◽  
...  
Keyword(s):  
Salicylic Acid ◽  
Caenorhabditis Elegans ◽  
Unfolded Protein Response ◽  
Acid Derivative ◽  
Unfolded Protein ◽  
Protein Response ◽  
Mitochondrial Unfolded Protein Response

scholarly journals Neuronal GPCR Controls Innate Immunity by Regulating Noncanonical Unfolded Protein Response Genes

Science ◽  
2011 ◽  
Vol 332 (6030) ◽  
pp. 729-732 ◽  
Author(s):  
J. Sun ◽  
V. Singh ◽  
R. Kajino-Sakamoto ◽  
A. Aballay
Keyword(s):  
Innate Immunity ◽  
Unfolded Protein Response ◽  
Unfolded Protein ◽  
Protein Response

scholarly journals Activation of the mitochondrial unfolded protein response does not predict longevity in Caenorhabditis elegans

2014 ◽  
Vol 5 (1) ◽  
Author(s):  
Christopher F. Bennett ◽  
Helen Vander Wende ◽  
Marissa Simko ◽  
Shannon Klum ◽  
Sarah Barfield ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Unfolded Protein Response ◽  
Unfolded Protein ◽  
Protein Response ◽  
Mitochondrial Unfolded Protein Response

scholarly journals The Mitochondrial Unfolded Protein Response Protects against Anoxia in Caenorhabditis elegans

PLoS ONE ◽  
2016 ◽  
Vol 11 (7) ◽  
pp. e0159989 ◽  
Author(s):  
Salvador Peña ◽  
Teresa Sherman ◽  
Paul S. Brookes ◽  
Keith Nehrke
Keyword(s):  
Caenorhabditis Elegans ◽  
Unfolded Protein Response ◽  
Unfolded Protein ◽  
Protein Response ◽  
Mitochondrial Unfolded Protein Response

scholarly journals FSHR-1/GPCR Regulates the Mitochondrial Unfolded Protein Response in Caenorhabditis elegans

Genetics ◽  
2019 ◽  
Vol 214 (2) ◽  
pp. 409-418 ◽  
Author(s):  
Sungjin Kim ◽  
Derek Sieburth
Keyword(s):  
Caenorhabditis Elegans ◽  
Unfolded Protein Response ◽  
Mitochondrial Stress ◽  
Unfolded Protein ◽  
Mitochondrial Homeostasis ◽  
Link Type ◽  
Link Functions ◽  
Evolutionarily Conserved ◽  
Protein Response ◽  
Mitochondrial Unfolded Protein Response

The mitochondrial unfolded protein response (UPRmt) is an evolutionarily conserved adaptive response that functions to maintain mitochondrial homeostasis following mitochondrial damage. In Caenorhabditis elegans, the nervous system plays a central role in responding to mitochondrial stress by releasing endocrine signals that act upon distal tissues to activate the UPRmt. The mechanisms by which mitochondrial stress is sensed by neurons and transmitted to distal tissues are not fully understood. Here, we identify a role for the conserved follicle-stimulating hormone G protein-coupled receptor, FSHR-1, in promoting UPRmt activation. Genetic deficiency of fshr-1 severely attenuates UPRmt activation and organism-wide survival in response to mitochondrial stress. FSHR-1 functions in a common genetic pathway with SPHK-1/sphingosine kinase to promote UPRmt activation, and FSHR-1 regulates the mitochondrial association of SPHK-1 in the intestine. Through tissue-specific rescue assays, we show that FSHR-1 functions in neurons to activate the UPRmt, to promote mitochondrial association of SPHK-1 in the intestine, and to promote organism-wide survival in response to mitochondrial stress. We propose that FSHR-1 functions cell nonautonomously in neurons to activate UPRmt upstream of SPHK-1 signaling in the intestine.

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