Association of serum apolipoprotein B48 level with the presence of carotid plaque in type 2 diabetes mellitus

2008 ◽  
Vol 81 (3) ◽  
pp. 338-344 ◽  
Author(s):  
Kyoko Tanimura ◽  
Yasushi Nakajima ◽  
Mototugu Nagao ◽  
Akira Ishizaki ◽  
Toshiko Kano ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Carotid Plaque ◽  
Apolipoprotein B48

scholarly journals Computed Tomography-Estimated Pancreatic Steatosis is a Risk Factor for Carotid Plaque in Type 2 Diabetes Mellitus Patients: A Cross-Sectional Study

2020 ◽  
Author(s):  
Pengtao Sun ◽  
Chunzhi Fan ◽  
Rengui Wang ◽  
Tongwei Chu ◽  
Xiaoli Sun ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Carotid Plaque ◽  
Fat Content ◽  
Cross Sectional ◽  
Pancreatic Fat ◽  
Pancreatic Steatosis ◽  
Pancreatic Fat Content

Abstract Background Pancreatic steatosis correlates with the thickness of arterial intima. However, the correlation between pancreatic steatosis and carotid atherosclerosis plaque, which better predict the prognosis of cardiovascular disease, is unclear. We aimed to explore potential effects of pancreatic fat content measured by computer tomography (CT) on carotid plaque in patients with type 2 diabetes mellitus (T2DM).Methods Patients with T2DM who underwent CT scan of the upper abdomen and ultrasound of the carotid artery were consecutively enrolled. Based on ultrasound results, the patients were divided into non-plaque group and plaque group, and the latter was categorized into hypoechoic plaque subgroup and non-hypoechoic plaque subgroup. The CT attenuation of pancreas and spleen were measured. Pancreas-to-spleen attenuation ratio (P/S) and difference between pancreatic and splenic attenuation (P-S) were calculated. The cut-off values of P/S and P-S were obtained using receiver operating characteristic (ROC) curves. Logistic regression models were used to evaluate association of P/S or P-S with carotid plaque or hypoechoic plaque.Results A total of 337 patients with T2DM were enrolled, including 101 cases (30.0%) in the non-plaque group, 146 cases (43.3%) in the hypoechoic plaque subgroup, and 90 cases (26.7%) in the non-hypoechoic plaque subgroup. P/S and P-S in plaque group were lower than those in non-plaque group, with a cut-off value of P/S and P-S as 0.72 and -13.33, respectively. After adjusting for risk factors, P/S and P-S correlated with carotid plaque [for low P/S: OR (95% CI): 3.15 (1.47-6.73), P=0.0031; for low P-S: OR (95% CI): 2.84 (1.42-5.66), P=0.0031] as well as carotid hypoechoic plaque [for low P/S: OR (95% CI): 1.82 (1.07-3.08), P=0.0259; for low P-S: OR (95% CI): 1.82 (1.09-3.02), P=0.021].Conclusions T2DM patients with carotid plaque have higher pancreatic fat content than those without. Pancreatic steatosis correlates with carotid plaque and hypoechoic plaque in T2DM patients.

Polymorphism rs2073618 of the osteoprotegerin gene as a potential marker of subclinical carotid atherosclerosis in Caucasians with type 2 diabetes mellitus

VASA ◽  
2017 ◽  
Vol 46 (5) ◽  
pp. 355-362 ◽  
Author(s):  
Aleš Pleskovič ◽  
Sara Mankoč Ramuš ◽  
Zala Jenko Pražnikar ◽  
Marija Šantl Letonja ◽  
Andreja Cokan Vujkovac ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Carotid Plaque ◽  
Carotid Atherosclerosis ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Increased Risk ◽  
Receptor Activator

Abstract. Background: The OPG/RANKL/RANK (osteoprotegerin/receptor-activator of nuclear factor κB ligand/receptor-activator of nuclear factor κB) axis has been recently linked to the development of atherosclerosis and plaque destabilization. We have investigated whether polymorphism rs2073618 of the OPG gene is associated with subclinical markers of carotid atherosclerosis in subjects with type 2 diabetes mellitus (T2DM). Patients and methods: 595 subjects with T2DM were enrolled in the cross-sectional study. Subclinical markers of carotid atherosclerosis (carotid intima media thickness, plaque thickness, and plaques presence) were assessed with ultrasound at the time of recruitment. Genotyping for rs2073618 (a missense variant located in exon I of the OPG gene) was performed, and OPG serum levels were determined by ELISA. Results: Compared to the GG genotype, the CC genotype of the rs2073618 polymorphism had a significantly increased risk for the presence of carotid plaque (OR = 2.54, 95 % CI = 1.22–5.28, p = 0.01). No statistically significant difference could be detected (p = 0.68) upon comparing median values of serum OPG levels among studied genotype groups in subjects with T2DM. Multivariable linear regression analyses in T2DM subjects demonstrated that GC and CC genotypes (p = 0.03 and p = 0.003), together with statin therapy (p = 0.009), were independent predictors of the number of carotid segments with plaques. Conclusions: Despite the fact that OPG rs2073618 genotypes failed to predict the serum OPG levels as there was no statistical difference among compared genotypes, our results demonstrate that the rs2073618 polymorphism could be a possible genetic marker for the prediction of increased risk for carotid plaque burden as a measure of advanced subclinical atherosclerosis in T2DM subjects.

scholarly journals Carotid plaque and type 2 diabetes mellitus

2019 ◽  
Vol 26 (06) ◽  
Author(s):  
Farhat Bashir ◽  
Ayesha Nageen ◽  
Saera Sohail Kidwai ◽  
Jamal Ara
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Carotid Plaque ◽  
Doppler Ultrasonography ◽  
Laboratory Data ◽  
P Value ◽  
Cross Sectional ◽  
Carotid Doppler

Atherosclerosis is the basic cause of macrovasular complications of diabetes mellitus. It affects all parts of the circulatory tree. An easy and reliable method of diagnosing atherosclerosis is Carotid Doppler ultrasonography. Increased Carotid Intima-Medial thickness (CIMT) and presence of carotid plaque is an important predictor of ischemic heart disease and cerebrovascular accidents. The purpose of this study was to find the association of carotid plaque with cardio-metabolic risk factors in type 2 diabetes mellitus. Study Design: Cross-sectional study. Setting:  Medical Out-patient Department of Creek General Hospital, Karachi. Period: One year from June 2015 to May 2016. Subjects and Methods: The study population included 119 cases of type 2 diabetes mellitus. All subjects underwent Carotid Doppler ultrasonography. The demographic, anthropometric, clinical and laboratory data was collected and analyzed through SPSS ver.20.0. The relationship of carotid plaque with different atherosclerotic variables was assessed by Student’s t-test and Chi-square test. P-value of <0.5 was considered significant. Results: Out of 119 patients with type 2 diabetes mellitus, 18.5% had a carotid plaque. The presence of plaque was associated with duration of diabetes, presence of hypertension, BMI, diastolic blood pressure, total cholesterol, triglyceride levels and CIMT. Conclusion: We need to focus on management of the multiple metabolic abnormalities associated with diabetes mellitus in order to prevent atherosclerosis and its associated cardiovascular disease.

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